Article
Engineering, Biomedical
Quan Wang, Hongshu Jing, Jun Lin, Zhihua Wu, Yu Tian, Ke Gong, Qianqian Guo, Xupeng Yang, Liting Wang, Zhaojun Li, Yourong Duan
Summary: Inflammation plays a major role in the progression of arteriosclerosis, and the complex inflammatory response in plaque is a result of various cells and cytokines interacting with each other. The programmed prodrug, LI NPs, targeting P-selectin, was developed as an anti-inflammatory agent to inhibit arteriosclerosis through multiple pathways. In experimental models, LI NPs significantly reduced plaque size and showed promising therapeutic effects.
Article
Chemistry, Multidisciplinary
Quan Wang, Yi Duan, Hongshu Jing, Zhihua Wu, Yu Tian, Ke Gong, Qianqian Guo, Jiali Zhang, Ying Sun, Zhaojun Li, Yourong Duan
Summary: The researchers designed a low molecular weight heparin-unsaturated fatty acid conjugate (LMWH-uFA) that acted as an antiatherosclerotic agent and a nanocarrier. This conjugate could regulate blood lipids and inhibit inflammation, leading to better therapeutic effects. In an atherosclerosis mouse model, the drug significantly reduced plaque area and showed promising curative effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Li Zhang, Linyu Zhu, Xiaohan Yao, Xiaohan Lou, Jiajia Wan, Xixi Duan, Longze Pan, Anqi Li, Zhuoyu Gu, Ming Wang, Fazhan Wang, Zhihai Qin
Summary: Chemotherapeutic drug paclitaxel (PTX) inhibits tumor growth at the injection site but enhances lymphatic metastasis of melanoma cells by upregulating C-C chemokine receptor type 7 (CCR7) expression and activating fNK and p38 signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Applied
Fahimeh Vahidi Ataabadi, Farnoush Oveissi, Mahmoud Etebari, Azade Taheri
Summary: The study aimed to investigate the anti-melanoma and anti-angiogenic effects of enoxaparin surface-coated dacarbazine-loaded chitosan nanoparticles (Enox-Dac-Chi NPs). The results showed that simultaneous delivery of dacarbazine and enoxaparin by chitosan nanoparticles can enhance the anti-melanoma effect of dacarbazine and prevent melanoma metastasis by its anti-angiogenic activity. Therefore, the designed nanoparticles can be introduced as effective drug delivery vehicles for the treatment and prevention of metastatic melanoma.
CARBOHYDRATE POLYMERS
(2023)
Article
Multidisciplinary Sciences
Esayas Tekle, Yemataw Gelaw, Mulat Dagnew, Aschalew Gelaw, Markos Negash, Eyuel Kassa, Segenet Bizuneh, Dessalew Wudineh, Fikir Asrie
Summary: This study assessed the value of basic coagulation parameters and factors associated with disease severity in risk stratification and prognosis among COVID-19 patients. The findings revealed that prolonged prothrombin time (PT) was associated with severe COVID-19 and poorer prognosis.
Article
Biochemistry & Molecular Biology
Dinglingge Cao, Huangjuan Li, Yuan Luo, Nianping Feng, Tianyuan Ci
Summary: The study developed a delivery system by loading the photosensitizer ICG into LMWH-modified liposomes to achieve better phototherapeutic efficacy and alleviate the potential risk of tumor metastasis caused by phototherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sami U. Khan, Ying Xia, David Goodale, Gabriella Schoettle, Alison L. Allan
Summary: The research found that lung-derived selectins can promote the metastatic behavior of TNBC, while selectin knockout can reduce the metastatic progression of TNBC in the lungs. Further studies are aimed at elucidating the pro-metastatic mechanisms of lung-derived selectins and developing a lung-directed therapeutic approach.
Article
Biochemistry & Molecular Biology
Heejin Lim, Taewoo Yang, Wongeun Lee, Sung-Gyoo Park
Summary: The study demonstrates that MDSCs are a source of MFGE8, which plays a role in tumor metastasis. TME positively regulates MFGE8 production by MDSCs through TGF-beta, suggesting MFGE8 as an important effector molecule for MDSCs to promote tumor metastasis.
Article
Medicine, Research & Experimental
Anush Chakraborty, Gargi Roy, Farheen Fatima, Bharati Swami, Sangeeta Bhaskar
Summary: Cancer-associated morbidity is mainly caused by tumor cells metastasizing from their primary site. Mycobacterium indicus pranii (MIP), an approved immunotherapy for lung cancer, has shown potent anti-tumor activity. In mouse models, MIP treatment resulted in fewer metastatic lesions. Further investigation revealed that MIP downregulated epithelial mesenchymal transition markers in B16F10 melanoma cells, suppressing their invasion, migration, and adhesion. MIP also upregulated PPAR gamma expression and downregulated CXCR4 surface expression, reducing the metastatic burden in melanoma models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Minjun Xu, Kaili Hu, Yipu Liu, Yukun Huang, Shanshan Liu, Yu Chen, Dayuan Wang, Songlei Zhou, Qian Zhang, Ni Mei, Huiping Lu, Fengan Li, Xiaoling Gao, Jun Chen
Summary: The failure of conventional clinical therapies in controlling tumor metastasis has led researchers to develop a systemic metastasis-targeted nanotherapeutic, combining an anti-inflammatory agent with an anti-thrombotic agent, which effectively hinders multiple steps of tumor metastasis. When used in combination with surgery or chemotherapy, this nanotherapeutic shows promise in inhibiting tumor metastasis and improving overall survival rates for tumor-bearing subjects.
NATURE COMMUNICATIONS
(2021)
Article
Biophysics
Yuyuan Zhou, Wenpeng Cao, Zhiliang Xu, Frank Zhang, Yaling Liu
Summary: Ligand-functionalized liposomes have been developed for targeted therapies, and the binding kinetics of proteins on liposomes compared to rigid surfaces show differences in affinity. The results suggest that protein orientation and diffusion on liposomal membrane can alter the binding kinetics of the protein-ligand interaction, providing insight for the design of future ligand-targeted liposomes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Xiaoying Zhang, Wenjing Tang, Haoyu Wen, Ercan Wu, Tianhao Ding, Jie Gu, Zhongwei Lv, Changyou Zhan
Summary: In this study, CTB protein was successfully conjugated with PEGylated liposomes to form CTB-sLip nanocarriers. The CTB-sLip demonstrated high targeting capability to human-derived colorectal cancer cells and lung metastasis in nude mice models. However, repeated injections of CTB-sLip induced the production of antibodies, but it still showed potential for the diagnosis of lung metastasis of colorectal cancer.
Article
Biochemistry & Molecular Biology
Zhi Cai, Yishu Yan, Juan Zhou, Yang Yang, Yan Zhang, Jinghua Chen
Summary: Novel brush-like glycopolymers (BGPs) were synthesized with BGP-SFH showing the highest anti-metastasis ability similar to heparin. In vitro assays demonstrated the efficacy of these glycopolymers in inhibiting cancer cell metastasis.
Article
Chemistry, Multidisciplinary
Yaping He, Ting Xiong, Siyu He, Hongyu Sun, Chenxi Huang, Xiaohong Ren, Li Wu, Laurence H. Patterson, Jiwen Zhang
Summary: The study synthesized RCLD nanoparticles with lung-targeting characteristics, which efficiently targeted lung tumors following intravenous administration, inhibited cancer cell migration and invasion, and reduced lung tumor count and spread area in vivo in lung cancer models. Furthermore, RCLD showed no signs of tissue damage or adverse hematologic effects, supporting its use for targeted treatment of lung cancer.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Oncology
Hans-Ake Fabricius, Sarah Starzonek, Tobias Lange
Summary: Platelets, as the smallest cells in the blood stream, play crucial roles in hemostasis, inflammation, immunity, and tissue repair. In malignancies, platelets are also involved in promoting metastasis and resistance to anti-tumor treatment. The complex interaction between platelets and cancer cells is still not fully understood, although various surface molecules and transduction mechanisms have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jianqing Peng, Zhaohui Jiang, Guoping Wu, Zimin Cai, Qianming Du, Ling Tao, Yanyan Zhang, Yi Chen, Xiangchun Shen
Summary: In this study, carboxymethyl chitosan-coated lipid nanoparticles for eucalyptol were developed to enhance its protective effects on hyperglycaemia-induced vascular endothelial injury, and the mechanism of eucalyptol was confirmed. Pharmacokinetics data demonstrated that the nanocarrier promoted the oral absorption of eucalyptol.
JOURNAL OF DRUG TARGETING
(2021)
Article
Pharmacology & Pharmacy
Yanyan Zhang, Li He, Mengxin Tu, Mei Huang, Yan Chen, Di Pan, Jianqing Peng, Xiangchun Shen
Summary: Research suggests that terpinen-4-ol can alleviate vascular calcification by inhibiting calcium deposition, phenotypic switching, and endoplasmic reticulum stress in vascular smooth muscle cells through the upregulation of SIRT1 expression. This study sheds light on the molecular mechanism of terpinen-4-ol and supports its potential as a therapeutic agent for chronic kidney disease-related vascular calcification.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Yi Chen, Zhaohui Jiang, Jinzhuan Xu, Jiyuan Zhang, Runbin Sun, Jia Zhou, Yuan Lu, Zipeng Gong, Jing Huang, Xiangchun Shen, Qianming Du, Jianqing Peng
Summary: A DEAE-DEX-coated bilosome with BER and CUR encapsulated was developed for the treatment of NAFLD, showing enhanced permeation and oral absorption in vivo. The synchronized biodistribution of BER and CUR in the liver contributed to optimal ameliorative effects on NAFLD, mainly mediated by anti-oxidation and anti-inflammation related pathways.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Di Pan, Wen Zhang, Nenling Zhang, Yini Xu, Yi Chen, Jianqing Peng, Yan Chen, Yanyan Zhang, Xiangchun Shen
Summary: In this study, the synergistic effects of the combination treatment with Oxymatrine (OMT) and Doxorubicin (DOX) on colorectal cancer cells were investigated, showing significant inhibition of tumor growth and migration, as well as enhanced apoptosis through ROS generation. The combination therapy also reduced cardiotoxicity and involved molecular alterations of specific proteins, suggesting a potential therapeutic strategy for CRC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jianqing Peng, Qin Wang, Jia Zhou, Shuli Zhao, Pan Di, Yan Chen, Ling Tao, Qianming Du, Xiangchun Shen, Yi Chen
Summary: An optimized nanoplatform for DHA and CQ combination therapy against colorectal cancer was developed in this study, showing potential efficacy in inhibiting proliferation and metastasis of tumor cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zimin Cai, Qin Wang, Jinzhuan Xu, Jia Zhou, Zhaohui Jiang, Di Pan, Yanyan Zhang, Ling Tao, Jianqing Peng, Yi Chen, Xiangchun Shen
Summary: Quantitative pulmonary administration of 1,8-cineole (CIN) can alleviate the progression of emphysema, and the therapeutic effects are further improved by the hyaluronic acid-coated liposome carrier.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ji-Yuan Zhang, Xiao-Xia Liu, Jia-Yi Lin, Xiao-Yan Bao, Jian-Qing Peng, Zi-Peng Gong, Xin Luan, Yi Chen
Summary: Oral administration is a commonly used route for drug delivery, but it is challenging due to barriers in the gastrointestinal tract. Researchers have developed virus-inspired nanoparticles (VINs) to overcome these barriers and enhance drug bioavailability. This article reviews the development and design strategies of VINs, summarizes the mechanisms and processes of oral absorption, and discusses the challenges in the clinical translation of oral nano-carriers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen, Xiangchun Shen
Summary: Pulmonary emphysema is a fatal lung disease characterized by progressive thinning, enlargement, and destruction of alveoli. Oxymatrine (OMT), a bioactive substance derived from traditional Chinese herbal Sophora flavescens, shows potential for alleviating pulmonary emphysema through its anti-inflammatory and antioxidative activities. The study developed OMT-loaded liposomes with carboxymethyl chitosan (CMCS) modification to improve in vivo stability and pulmonary retention of OMT. The CMCS-modified liposomes exhibited superior ameliorative effects on emphysema and OMT further enhanced its anti-inflammatory and antioxidative effects. Pulmonary administration of OMT is a potential strategy for emphysema treatment and can be further improved by CMCS-modified liposomes.
Article
Engineering, Biomedical
Jianqing Peng, Xiaoxia Hu, Shuangqin Fan, Jia Zhou, Shuang Ren, Runbin Sun, Yi Chen, Xiangchun Shen, Yan Chen
Summary: The study demonstrates the potential of using shikonin for the treatment of triple-negative breast cancer by targeting mitochondrial biogenesis. The researchers designed a biomimetic micelle to improve the delivery of shikonin to tumor lesions and mitochondria. The micelle showed promising results in inhibiting tumor growth and metastasis in a mouse model of triple-negative breast cancer. This study highlights the importance of mitochondria-targeted therapies for the treatment of triple-negative breast cancer.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Peng, Qin Wang, Mingyang Guo, Chunyuan Liu, Xuesheng Chen, Ling Tao, Ke Zhang, Xiangchun Shen
Summary: In this study, a CS-coated liposome loaded with OMT was used for the treatment of lethal RSV infection. The CS-coated liposome enhanced the distribution and retention of OMT in lung tissue, effectively alleviating RSV infection. Thus, the CS-coated liposome could be a potential inhalable nanocarrier for preventing pulmonary infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yi Chen, Jianing Wang, Jinzhuan Xu, Jiyuan Zhang, Shan Xu, Qing Zhang, Jing Huang, Jianqing Peng, Haiyu Xu, Qianming Du, Zipeng Gong
Summary: Atherosclerosis is a systemic disease characterized by lipid deposition in blood vessel walls, and effective therapeutic drugs are needed for long-term treatment. This study developed a nanoemulsion using a polysaccharide-protein/protein complex as an emulsifier and vitamin B12 as a ligand to improve the stability and oral bioavailability of 1,8-cineole (CIN), a potential treatment for atherosclerosis. The nanoemulsion showed improved stability of CIN, prolonged retention time in the gastrointestinal tract, enhanced permeability, and increased plaque accumulation. In an atherosclerosis mouse model, the nanoemulsion achieved significant therapeutic efficacy. This study demonstrates the potential of using nanoemulsions for the oral delivery of essential oils.
Article
Pharmacology & Pharmacy
Die Hu, Shintaro Fumoto, Naoki Yoshikawa, Jianqing Peng, Hirotaka Miyamoto, Masakazu Tanaka, Koyo Nishida
Summary: Cationic lipid-based lipoplexes were prepared with different sizes and incubated with plasmid DNA at different temperatures to investigate the relationship between physicochemical characteristics and transfection efficiency. The diffusion coefficient of liposomes during lipoplex formation was found to strongly correlate with the physicochemical characteristics of lipoplexes, accessibility of plasmid DNA in lipoplexes, and gene expression per metabolic activity. Clathrin-mediated endocytosis was the major route for lipoplexes comprising 100 nm-liposomes, but as liposome size increased, the major route shifted to lipid raft-mediated endocytosis, with macropinocytosis observed for all liposome sizes. The role of reactive oxygen species may depend on liposome size and endocytosis. This study provides valuable information for understanding cationic lipoplex-mediated transfection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ji-Yuan Zhang, Wei-Dong Gao, Jia-Yi Lin, Shan Xu, Li-Jun Zhang, Xin-Chen Lu, Xin Luan, Jian-Qing Peng, Yi Chen
Summary: Melanoma, the most aggressive form of skin cancer, requires effective anti-melanoma therapies due to its high metastatic ability and low response rate. Traditional phototherapy has been found to trigger immunogenic cell death (ICD) to activate antitumor immune response, but limited tumor accumulation of photosensitizers/photothermal agents and immunosuppressive tumor microenvironment weaken the immune effects. Nanotechnology enables higher accumulation of photosensitizers/photothermal agents at the tumor site, thus improving the antitumor effects of photo-immunotherapy (PIT).
JOURNAL OF DRUG TARGETING
(2023)
Article
Biochemistry & Molecular Biology
Jinzhuan Xu, Zhaohui Jiang, Jianqing Peng, Runbin Sun, Lili Zhang, Yan Chen, Di Pan, Jing Huang, Zipeng Gong, Yi Chen, Xiangchun Shen
Summary: Injury to vascular endothelial cells caused by high glucose is a driving factor in the development of vascular complications in diabetes. Essential oil extracts from Chinese medicine have therapeutic effects on this injury, but poor oral absorption limits their effectiveness. The development of nanocarriers for essential oils is a promising strategy to improve oral absorption in diabetes treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Plant Sciences
Zi-Min Cai, Jian-Qing Peng, Yi Chen, Ling Tao, Yan-Yan Zhang, Ling-Yun Fu, Qing-De Long, Xiang-Chun Shen
Summary: 1,8-Cineole, extracted from plant essential oils, has pharmacological properties such as anti-inflammatory and antioxidant effects, making it useful for treating respiratory and cardiovascular diseases. Research has focused on its application and formulation development, providing direction for future studies.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
