Article
Computer Science, Theory & Methods
Song Yang, Fan Li, Stojan Trajanovski, Ramin Yahyapour, Xiaoming Fu
Summary: NFV is recognized as a next-generation network service provisioning paradigm, utilizing VNFs in a virtualized environment for service functions, with delay calculation and VNF protection models being important QoS parameters. The article provides an overview of four representative resource allocation problems in NFV, and categorizes and summarizes solutions considering various QoS parameters and scenarios.
IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Nir Hecht, Caroline L. Monteil, Guy Perriere, Marina Vishkautzan, Eyal Gur
Summary: This study investigates the differences in functionality between two homologous bacterial enzymes, PafA and Dop, by analyzing their amino acid sequences and structural elements. Through reciprocal mutagenesis, researchers were able to alter the activity of the enzymes and identify key residues and structural components responsible for their unique functions. The study demonstrates the evolutionary pathways that led to the emergence of novel catalytic functions in these enzymes.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Hongjie Li, Jasper Janssens, Maxime De Waegeneer, Sai Saroja Kolluru, Kristofer Davie, Vincent Gardeux, Wouter Saelens, Fabrice David, Maria Brbic, Jure Leskovec, Colleen N. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, Sudhir Gopal Tattikota, Frank Schnorrer, Katja Rust, Todd G. Nystul, Zita Carvalho-Santos, Carlos Ribeiro, Soumitra Pal, Sharvani Mahadevaraju, Teresa M. Przytycka, Aaron M. Allen, Stephen F. Goodwin, Cameron W. Berry, Margaret T. Fuller, Helen White-Cooper, Erika L. Matunis, Stephen DiNardo, Anthony Galenza, Lucy Erin O'Brien, Julian A. T. Dow, Heinrich Jasper, Brian Oliver, Norbert Perrimon, Bart Deplancke, Stephen R. Quake, Liqun Luo, Stein Aerts
Summary: This study presents a single-cell atlas of the fruit fly Drosophila melanogaster, including 580,000 nuclei and annotations of over 250 distinct cell types. It serves as a valuable resource for the Drosophila community and provides a reference for studying genetic perturbations and disease models at single-cell resolution.
Review
Chemistry, Physical
Longcheng Zhang, Haitao Zhao, Siran Xu, Qian Liu, Tingshuai Li, Yonglan Luo, Shuyan Gao, Xifeng Shi, Abdullah M. Asiri, Xuping Sun
Summary: This review discusses recent progress in electrocatalytic water splitting using advanced electrospun nanomaterials, covering fundamentals, structure design, and electrocatalytic properties. The review highlights the importance of designing 1D nanocatalysts with large surface area, high electronic conductivity, and tunable composition to improve the efficiency of electrochemical water splitting. The future perspectives and challenges in designing next-generation 1D electrospun nanocatalysts for electrochemical water splitting are also outlined.
Review
Engineering, Chemical
Nor Naimah Rosyadah Ahmad, Wei Lun Ang, Choe Peng Leo, Abdul Wahab Mohammad, Nidal Hilal
Summary: This paper highlights the importance of saline wastewater treatment and the potential of membrane technology in this field, presenting the advantages of membrane processes in water reclamation and resource recovery. It also discusses membrane fouling issues and the effectiveness of various fouling mitigation strategies.
Review
Chemistry, Inorganic & Nuclear
Xinhua Yuan, Manzhou Zhu
Summary: Compared with metal nanoparticles, atomically precise nanoclusters provide a more advantageous platform for investigating electrocatalysis at the atomic or molecular scale. This review summarizes recent advances in atomically precise metal nanoclusters and discusses their electrocatalytic applications, including hydrogen evolution reaction, electrochemical synthesis of ammonia, electrochemical CO2 reduction reaction, fuel cell reaction, and pollutant degradation reaction. The key factors affecting their electrocatalytic performance are also detailed, along with suggestions for improvements and future perspectives.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Yuting Luo, Zhiyuan Zhang, Manish Chhowalla, Bilu Liu
Summary: The electrochemical water splitting technology is crucial for achieving global carbon neutrality. High-performance electrocatalysts that can operate at high current densities are essential for the industrial implementation of this technology. Recent advancements in this field have led to the development of various catalysts designed specifically for high current densities (> 200 mA cm(-2)). This article discusses these recent advances and summarizes the key factors that influence the catalytic performance in high current density electrocatalysis, including catalyst dimensionality, surface chemistry, electron transport path, morphology, and catalyst-electrolyte interaction. It highlights the importance of a multiscale design strategy that considers these factors comprehensively for developing high current density electrocatalysts. The article also provides insights into the future directions of this emerging field.
ADVANCED MATERIALS
(2022)
Review
Energy & Fuels
Mohamad Sahban Alnarabiji, Shik Chi Edman Tsang, Abdul Hanif Mahadi
Summary: This paper reviews the fabrication methods of working electrodes for electrochemical water splitting, including both chemical and physical methods. The research direction in this field is demonstrated by analyzing articles in the database. The advantages and disadvantages of the reported fabrication methods are critically assessed.
Review
Biochemical Research Methods
Yichao Han, Albert Tafur Rangel, Kyle R. Pomraning, Eduard J. Kerkhoven, Joonhoon Kim
Summary: Genome-scale metabolic models (GEMs) provide a comprehensive view of fungal cellular metabolism and enhance performance predictions in biomanufacturing.
CURRENT OPINION IN BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lu-Ning Liu
Summary: Carboxysomes are bacterial microcompartments that encapsulate the primary CO2-fixing enzyme Rubisco within a virus-like protein shell. They play a central role in CO2 fixation in bacteria by providing elevated levels of CO2 to maximize carboxylation. Recent research has provided new insights into the assembly and functional maintenance of carboxysomes in bacteria and has explored their potential applications in synthetic biology.
TRENDS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jing Hu, Yuru Zhou, Yinan Liu, Zhichao Xu, Haijin Li
Summary: Developing earth-abundant and highly effective electrocatalysts for electrocatalytic water splitting is crucial for the future hydrogen energy society. Manganese-based materials have emerged as one of the most promising candidates due to their abundance, low cost, adjustable electronic properties, and excellent stability. However, their performance still falls short compared to Pt, necessitating further research to enhance their catalytic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Yuanlin Xu, Chen Wang, Yunhui Huang, Jing Fu
Summary: Hydrogen as a clean energy resource is seen as a promising alternative to address energy crisis and environmental pollution. Electrochemical water splitting, including HER and OER, is essential for hydrogen production. Research focusing on developing electrocatalysts for water splitting in neutral conditions has been reviewed, with emphasis on understanding reaction mechanisms, rate-determining steps, and activity correlations. Single-atom catalysts show potential for high efficiency and activity, while three-dimensional freestanding electrodes are a growing trend for large-current-density operations. Challenges and future directions for neutral water electrolysis are discussed to guide the design of electrocatalysts for efficient hydrogen production at scale.
Review
Biochemistry & Molecular Biology
Tingting Yao, Heng Xiao, Hong Wang, Xiaowei Xu
Summary: Proteolysis-targeting chimera (PROTAC) is a promising molecule that degrades specific proteins through the ubiquitin-proteasome system. It has shown remarkable efficacy in various fields and opened up new avenues for biomedical research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Jianhua Yang, Ran Tu, Huiling Yuan, Qinhong Wang, Leilei Zhu
Summary: Enzymes and cell factories are crucial in industrial biotechnology for chemical and fuel production. Laboratory evolution combined with high-throughput screening methods is commonly used to improve their properties and performances, addressing challenges in production processes.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Article
Genetics & Heredity
Sandip De, Sarah. B. B. Kingan, Chrysoula Kitsou, Daniel. M. M. Portik, Shelby. D. D. Foor, Julia. C. C. Frederick, Vipin. S. S. Rana, Nicole. S. S. Paulat, David. A. A. Ray, Yan Wang, Travis. C. C. Glenn, Utpal Pal
Summary: This study presents the assembly of a high-quality genome of Ixodes scapularis by sequencing two haplotypes within one individual. The genome includes new protein-coding genes and various RNA species, providing critical genetic resources and biological insights for tick research and interventions against tick-transmitted infections.
Article
Biochemistry & Molecular Biology
Antonio J. M. Ribeiro, Gemma L. Holliday, Nicholas Furnham, Jonathan D. Tyzack, Katherine Ferris, Janet M. Thornton
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Yana Valasatava, Antonio Rosato, Nicholas Furnham, Janet M. Thornton, Claudia Andreini
JOURNAL OF INORGANIC BIOCHEMISTRY
(2018)
Correction
Genetics & Heredity
Francesc Coll, Jody Phelan, Grant A. Hill-Cawthorne, Mridul B. Nair, Kim Mallard, Shahjahan Ali, Abdallah M. Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O. Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C. Crampin, Keertan Dheda, Nicholas Furnham, Judith R. Glynn, Louis Grandjean, Dang Minh Ha, Rumina Hasan, Zahra Hasan, Martin L. Hibberd, Moses Joloba, Edward C. Jones-Lopez, Tomoshige Matsumoto, Anabela Miranda, David J. Moore, Nora Mocillo, Stefan Panaiotov, Julian Parkhill, Carlos Penha, Joao Perdigao, Isabel Portugal, Zineb Rchiad, Jaime Robledo, Patricia Sheen, Nashwa Talaat Shesha, Frik A. Sirgel, Christophe Sola, Erivelton Oliveira Sousa, Elizabeth M. Streicher, Paul Van Helden, Miguel Viveiros, Robert M. Warren, Ruth McNerney, Arnab Pain, Taane G. Clark
Article
Genetics & Heredity
Francesc Coll, Jody Phelan, Grant A. Hill-Cawthorne, Mridul B. Nair, Kim Mallard, Shahjahan Ali, Abdallah M. Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O. Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C. Crampin, Keertan Dheda, Nicholas Furnham, Judith R. Glynn, Louis Grandjean, Dang Minh Ha, Rumina Hasan, Zahra Hasan, Martin L. Hibberd, Moses Joloba, Edward C. Jones-Lopez, Tomoshige Matsumoto, Anabela Miranda, David J. Moore, Nora Mocillo, Stefan Panaiotov, Julian Parkhill, Carlos Penha, Joao Perdigao, Isabel Portugal, Zineb Rchiad, Jaime Robledo, Patricia Sheen, Nashwa Talaat Shesha, Frik A. Sirgel, Christophe Sola, Erivelton Oliveira Sousa, Elizabeth M. Streicher, Paul Van Helden, Miguel Viveiros, Robert M. Warren, Ruth McNerney, Arnab Pain, Taane G. Clark
Article
Multidisciplinary Sciences
Stephanie Portelli, Jody E. Phelan, David B. Ascher, Taane G. Clark, Nicholas Furnham
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Sandra Giuliani, Arthur C. Silva, Joyce V. V. B. Borba, Pablo I. P. Ramos, Ross A. Paveley, Eugene N. Muratov, Carolina Horta Andrade, Nicholas Furnham
PLOS COMPUTATIONAL BIOLOGY
(2018)
Review
Chemistry, Multidisciplinary
Lauro Ribeiro de Souza Neto, Jose Teofilo Moreira-Filho, Bruno Junior Neves, Rocio Lucia Beatriz Riveros Maidana, Ana Carolina Ramos Guimaraes, Nicholas Furnham, Carolina Horta Andrade, Floriano Paes Silva
FRONTIERS IN CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Stephanie Portelli, Yoochan Myung, Nicholas Furnham, Sundeep Chaitanya Vedithi, Douglas E. V. Pires, David B. Ascher
SCIENTIFIC REPORTS
(2020)
Review
Immunology
Jose T. Moreira-Filho, Arthur C. Silva, Rafael F. Dantas, Barbara F. Gomes, Lauro R. Souza Neto, Jose Brandao-Neto, Raymond J. Owens, Nicholas Furnham, Bruno J. Neves, Floriano P. Silva-Junior, Carolina H. Andrade
Summary: This review focuses on innovative approaches to identify antischistosomal drug candidates, including the use of automated assays, fragment-based screening, computer-aided, and artificial intelligence-based computational methods. Current developments may contribute to optimizing research outputs and lead to more effective drugs for this highly prevalent disease in a more cost-effective drug discovery endeavor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tanushree Tunstall, Jody Phelan, Charlotte Eccleston, Taane G. Clark, Nicholas Furnham
Summary: Resistance to drugs used to treat tuberculosis disease remains a public health burden, with missense mutations in Mycobacterium tuberculosis bacteria affecting the stability and ligand affinity of the pncA protein. Multiple mutations at active site residues highlight mutational diversity due to selection pressures. Weak associations were found between genomic measures and biophysical effects of mutations, but statistically significant differences in structural features were observed for mutations associated with PZA resistance. Additionally, a distinct protein stability profile was seen for mutations in M. tuberculosis lineage 1 compared to modern lineages.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Editorial Material
Chemistry, Multidisciplinary
Floriano P. Silva-Jr, Siva S. Panda, Carolina Horta Andrade, Nicholas Furnham
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tanushree Tunstall, Stephanie Portelli, Jody Phelan, Taane G. Clark, David B. Ascher, Nicholas Furnham
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Joyce V. B. Borba, Arthur C. Silva, Pablo I. P. Ramos, Nathalia Grazzia, Danilo C. Miguel, Eugene N. Muratov, Nicholas Furnham, Carolina H. Andrade
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Janet Thornton, Jonathan Tyzack, Antonio Ribeiro, Gemma Holliday, Ian Sillitoe, Christine Orengo, Sergio Martinez Cuesta, Syed Asad Rahman, Nicholas Furnham
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Antonio Ribeiro, Gemma Holliday, Nicholas Furnham, Janet Thornton
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)