Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
Authors
Keywords
-
Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue 18, Pages 8924-8941
Publisher
Oxford University Press (OUP)
Online
2015-09-18
DOI
10.1093/nar/gkv892
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
- (2015) Xiaoling Wang et al. NATURE BIOTECHNOLOGY
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
- (2015) Isaac B Hilton et al. NATURE BIOTECHNOLOGY
- DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization
- (2015) John S. Schreck et al. NUCLEIC ACIDS RESEARCH
- A Cas9-guide RNA complex preorganized for target DNA recognition
- (2015) F. Jiang et al. SCIENCE
- CRISPR Immunity Drives Rapid Phage Genome Evolution in Streptococcus thermophilus
- (2015) David Paez-Espino et al. mBio
- Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA
- (2015) Dmitriy A. Khodakov et al. Scientific Reports
- Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection
- (2015) Marius Rutkauskas et al. Cell Reports
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
- (2014) Alexandra E. Briner et al. MOLECULAR CELL
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
- (2014) Samuel H. Sternberg et al. NATURE
- Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
- (2014) Xuebing Wu et al. NATURE BIOTECHNOLOGY
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
- (2014) Cem Kuscu et al. NATURE BIOTECHNOLOGY
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage
- (2014) Regina Cencic et al. PLoS One
- Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
- (2014) Mark D. Szczelkun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
- (2014) M. Jinek et al. SCIENCE
- Clustering by fast search and find of density peaks
- (2014) A. Rodriguez et al. SCIENCE
- Programmable energy landscapes for kinetic control of DNA strand displacement
- (2014) Robert R. F. Machinek et al. Nature Communications
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
- (2013) Luke A. Gilbert et al. CELL
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Cas9 as a versatile tool for engineering biology
- (2013) Prashant Mali et al. NATURE METHODS
- RNA-guided gene activation by CRISPR-Cas9–based transcription factors
- (2013) Pablo Perez-Pinera et al. NATURE METHODS
- CRISPR RNA–guided activation of endogenous human genes
- (2013) Morgan L Maeder et al. NATURE METHODS
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Phage mutations in response to CRISPR diversification in a bacterial population
- (2012) Christine L. Sun et al. ENVIRONMENTAL MICROBIOLOGY
- Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
- (2012) G. Gasiunas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes
- (2010) Norman E. Watkins et al. NUCLEIC ACIDS RESEARCH
- Programming biomolecular self-assembly pathways
- (2008) Peng Yin et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now