Heme activation by DNA: isoguanine pentaplexes, but not quadruplexes, bind heme and enhance its oxidative activity

From Cascaded Catalytic Nucleic Acids to Enzyme–DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations, and Assembly of Complex Structures

(2014) Fuan Wang et al.   CHEMICAL REVIEWS

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

G-Quadruplex Structures Formed by Expanded Hexanucleotide Repeat RNA and DNA from the Neurodegenerative Disease-Linked C9orf72 Gene Efficiently Sequester and Activate Heme

(2014) Jason C. Grigg et al.   PLoS One

DNA Nanotechnology: From Sensing and DNA Machines to Drug-Delivery Systems

(2013) Chun-Hua Lu et al.   ACS Nano

The Disease-associated r(GGGGCC)nRepeat from theC9orf72Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures

(2013) Kaalak Reddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity enhancement of G-quadruplex/hemin DNAzyme by spermine

(2013) Cui Qi et al.   RSC Advances

Solution Structure of a Parallel-Stranded Oligoisoguanine DNA Pentaplex Formed by d(T(iG)4T) in the Presence of Cs+ Ions

(2012) Mijeong Kang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interaction between the Heme and a G-Quartet in a Heme–DNA Complex

(2012) Kaori Saito et al.   INORGANIC CHEMISTRY

Insights into how nucleotide supplements enhance the peroxidase-mimicking DNAzyme activity of the G-quadruplex/hemin system

(2012) Loic Stefan et al.   NUCLEIC ACIDS RESEARCH

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

(2012) Pietro Fratta et al.   Scientific Reports

Peroxidase-mimicking DNAzymes for biosensing applications: A review

(2011) Joanna Kosman et al.   ANALYTICA CHIMICA ACTA

A Hemin/G-Quadruplex Acts as an NADH Oxidase and NADH Peroxidase Mimicking DNAzyme

(2011) Eyal Golub et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Harnessing Nature’s Insights: Synthetic Small Molecules with Peroxidase-Mimicking DNAzyme Properties

(2011) Loic Stefan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Characterization of G-Quadruplex/Hemin Peroxidase: Substrate Specificity and Inactivation Kinetics

(2011) Xiaojuan Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

DNA-Based Peroxidation Catalyst-What Is the Exact Role of Topology on Catalysis and Is There a Special Binding Site for Catalysis?

(2011) Shizuka Nakayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: how do they do it and what does it mean?

(2011) Dipankar Sen et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Guanine-Rich RNAs and DNAs That Bind Heme Robustly Catalyze Oxygen Transfer Reactions

(2011) Lester C.-H. Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplexes: From Guanine Gels to Chemotherapeutics

(2011) Tracy M. Bryan et al.   MOLECULAR BIOTECHNOLOGY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

Positive Effects of ATP on G-Quadruplex-Hemin DNAzyme-Mediated Reactions

(2010) De-Ming Kong et al.   ANALYTICAL CHEMISTRY

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

Structure–function study of peroxidase-like G-quadruplex-hemin complexes

(2009) De-Ming Kong et al.   ANALYST

General Peroxidase Activity of G-Quadruplex−Hemin Complexes and Its Application in Ligand Screening

(2009) Xiaohong Cheng et al.   BIOCHEMISTRY

Examination of the Effect of the Annealing Cation on Higher Order Structures Containing Guanine or Isoguanine Repeats

(2009) Sarah E. Pierce et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplex Aptamers with Peroxidase-Like DNAzyme Functions: Which Is the Best and How Does it Work?

(2009) Tao Li et al.   Chemistry-An Asian Journal

Colorimetric Split G-Quadruplex Probes for Nucleic Acid Sensing: Improving Reconstituted DNAzyme’s Catalytic Efficiency via Probe Remodeling

(2009) Shizuka Nakayama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogenic compounds

(2009) Shizuka Nakayama et al.   Molecular BioSystems

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY