Metabolic-intermediate complex formation with cytochrome P450: Theoretical studies in elucidating the reaction pathway for the generation of reactive nitroso intermediate

Do Two Different Reaction Mechanisms Contribute to the Hydroxylation of Primary Amines by Cytochrome P450?

(2011) Patrik Rydberg et al.   Journal of Chemical Theory and Computation

Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem

(2010) K. L. Hanson et al.   DRUG METABOLISM AND DISPOSITION

Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

(2010) J. Rittle et al.   SCIENCE

P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

(2009) Sason Shaik et al.   CHEMICAL REVIEWS

Oxidation of Tertiary Amines by Cytochrome P450-Kinetic Isotope Effect as a Spin-State Reactivity Probe

(2009) Chunsen Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantum Mechanics/Molecular Mechanics Studies on the Sulfoxidation of Dimethyl Sulfide by Compound I and Compound 0 of Cytochrome P450: Which Is the Better Oxidant?†

(2009) Cristina S. Porro et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Sulfoxide, Sulfur, and Nitrogen Oxidation and Dealkylation by Cytochrome P450

(2008) Patrik Rydberg et al.   Journal of Chemical Theory and Computation

Is the Bound Substrate in Nitric Oxide Synthase Protonated or Neutral and What Is the Active Oxidant that Performs Substrate Hydroxylation?

(2008) Sam P. de Visser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

(2007) Paul F. Hollenberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY