Article
Surgery
Dan Chen, Ding-Fu Zhong, Yi Yang, Si-Shuang Chen, Dong Liu
Summary: In this case report, a patient with primary colonic MALT lymphoma was diagnosed using electronic staining endoscopy and magnifying endoscopy. The patient underwent ESD for diagnosis and additional surgical treatment based on PET-CT results. The study suggests that ESD may be a feasible option for treating massive colorectal MALT lymphoma.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Reut Book, Jonathan Ben-Ezra, Chen Glait Santar, Sigi Kay, Galia Stemer, Howard S. Oster, Moshe Mittelman
Summary: Lymphoid aggregates (LA) are occasionally seen in bone marrow biopsies (BMB) of myelodysplastic syndromes (MDS) patients. This study evaluated their incidence and association with prognosis. The results showed that LA are relatively common (24%) in MDS patients and may indicate poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Yue Zhang, Takeshi Yamamoto, Shusaku Hayashi, Makoto Kadowaki
Summary: The study demonstrated that Astragaloside IV (As-IV) and oxymatrine (Oxy) can ameliorate colitis by suppressing plasmacytoid dendritic cell (pDCs) migration, suggesting a potential therapeutic approach for colonic inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Keiki Nagaharu, Yasuhiro Kojima, Haruka Hirose, Kodai Minoura, Kunihiko Hinohara, Hirohito Minami, Yuki Kageyama, Yuka Sugimoto, Masahiro Masuya, Shigeru Nii, Masahide Seki, Yutaka Suzuki, Isao Tawara, Teppei Shimamura, Naoyuki Katayama, Hiroyoshi Nishikawa, Kohshi Ohishi
Summary: This study identifies large fluctuating transcriptome dynamics during the bifurcation process of human B-plasmacytoid DC, and provides a computational model to reconcile continuous and discrete models based on these fluctuations.
Article
Immunology
Vanessa Chilunda, Jessica Weiselberg, Samuel Martinez-Meza, Lwidiko E. Mhamilawa, Laura Cheney, Joan W. Berman
Summary: HIV-associated neurocognitive impairment (HIV-NCI) persists in a significant percentage of people with HIV despite effective antiretroviral therapy. Using RNA-sequencing, this study found that methamphetamine increases the infiltration of mature monocytes into the central nervous system, leading to dysregulated inflammatory responses and viral reservoir establishment and persistence, both of which contribute to neuronal damage. The study highlights potential molecules that may be targeted for therapy to limit the effects of meth on HIV neuropathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yosuke Senju, Toiba Mushtaq, Helena Vihinen, Aki Manninen, Juha Saarikangas, Katharina Ven, Ulrike Engel, Markku Varjosalo, Eija Jokitalo, Pekka Lappalainen
Summary: The MTSS1 protein binds to the Arp2/3 and WAVE-2 protein complexes, promoting the formation of dynamic membrane folds at cell-cell junctions and enhancing the integrity of these junctions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Tomomitsu Tahara, Kazuya Takahama, Sayumi Tahara, Noriyuki Horiguchi, Kohei Funasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Hiro-o Ieda, Toshiro Fukui, Makoto Naganuma, Naoki Ohmiya
Summary: Lymphoid follicles hyperplasia (LH) is a small, round, yellowish-white nodules sometimes found in the normal colon. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. This study investigated the presence of LH in the normal colonic mucosa and its association with the incidence of colorectal lesions including colorectal cancer, adenoma, and hyperplastic polyp.
Article
Multidisciplinary Sciences
Bettina Kunze, Moritz Middelhoff, H. Carlo Maurer, Tatiana Agibalova, Akanksha Anand, Anne-Marie Buhrer, Hsin-Yu Fang, Theresa Baumeister, Katja Steiger, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante
Summary: Activation of the Notch signaling pathway in Dclk1-positive tuft cells accelerates the development of BE, while genetic ablation of Notch receptor 2 in Dclk1-positive cells delays BE progression and leads to increased secretory cell differentiation. This suggests that Notch activation plays a role in BE development.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Felipe Castro-Martinez, Maria Del Rocio Encarnacion-Garcia, Aurora Candelario-Martinez, Oscar Medina-Contreras, Genaro Patino-Lopez, Michael Schnoor, Porfirio Nava
Summary: The impairment of epithelial barrier and micro-erosions are associated with the development of pathologies such as inflammatory bowel diseases. The use of a 10 kDa fluorescent dye can help visualize high permeability regions in the colonic mucosa, providing an important tool for studying intestinal epithelial barrier function.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Multidisciplinary Sciences
Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas, Xabier Martinez-de-Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C. Vinado, Patxi San Martin-Uriz, Juan P. Romero, Delia Quilez Agreda, Marta Minana Barrios, Ignacio Sancho-Gonzalez, Gabriele Todisco, Luca Malcovati, Nuria Planell, Borja Saez, Jesper N. Tegner, Felipe Prosper, David Gomez-Cabrero
Summary: This study developed a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing datasets, providing a comprehensive description of the regulatory microenvironment of HSCs in mice and suggesting conserved features in humans.
Review
Gastroenterology & Hepatology
Francois Blachier, Mireille Andriamihaja, Pierre Larraufie, Eunyeong Ahn, Annaig Lan, Eunjung Kim
Summary: Hydrogen sulfide (H2S) is a bacterial metabolite that affects the intestinal physiology and physiopathology through multiple sources and metabolic pathways in colonocytes. Different concentrations of H2S production have different effects on colon mucosa, playing a crucial role in cellular energy metabolism and development.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Chien-Hung Lu, Wei-Yu Kao, Chun-Chao Chang, Yu-An Kan
Summary: We report a rare case of colonic extranodal mucosa-associated lymphoid tissue (MALT) lymphoma causing hematochezia, which was successfully treated with endoscopic mucosal resection. Colonic MALT lymphoma is a rare disease, and could present as hematochezia. En bloc endoscopic resection can achieve long-term remission.
Article
Pathology
Mark G. Evans, Russell K. Brynes, Anthony Crymes, Jack Reid, Nahideh Haghighi, Christopher Botros, Xiaohui Zhao, Sherif A. Rezk
Summary: The distinction between benign and malignant lymphoid aggregates in bone marrow specimens can be challenging. In addition to morphological and immunophenotypic evaluation, detection of immunoglobulin gene rearrangements may be necessary to confirm malignancy. This study found that clonal rearrangements were present in both malignant and benign cases, highlighting the importance of comprehensive evaluation and molecular analysis for accurate diagnosis.
Article
Oncology
Wei-Kun Shi, Yun-Hao Li, Xue-Shan Bai, Guo-Le Lin
Summary: This study used bioinformatics to search for genes associated with the prognosis of colorectal cancer (CRC), and identified several genes that may be important for CRC prognosis. Further experiments confirmed the role of one of these genes, CDKN2A, in colorectal cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biophysics
Mohamad Mohty, Florent Malard, Manuel Abecasis, Erik Aerts, Ahmed S. Alaskar, Mahmoud Aljurf, Mutlu Arat, Peter Bader, Frederic Baron, Grzegorz Basak, Ali Bazarbachi, Didier Blaise, Fabio Ciceri, Selim Corbacioglu, Jean-Hugues Dalle, Fiona Dignan, Takahiro Fukuda, Anne Huynh, Jurgen Kuball, Silvy Lachance, Hillard Lazarus, Tamas Masszi, Mauricette Michallet, Arnon Nagler, Mairead NiChonghaile, Shinichiro Okamoto, Antonio Pagliuca, Christina Peters, Finn B. Petersen, Paul G. Richardson, Tapani Ruutu, Wael Saber, Bipin N. Savani, Robert Soiffer, Jan Styczynski, Elisabeth Wallhult, Ibrahim Yakoub-Agha, Rafael F. Duarte, Enric Carreras
BONE MARROW TRANSPLANTATION
(2020)
Article
Biophysics
E. Gonzalez-Barca, A. Boumendil, D. Blaise, M. Trneny, T. Masszi, H. Finel, M. G. Michieli, J. T. Bittenbring, G. Gritti, J. A. Snowden, M. Bishton, B. Bruno, S. Gonzalez de Villambrosia, A. Janikova, X. Leleu, A. Anagnostopoulos, X. Poire, M. Crysandt, Z. N. Ozkurt, E. Vandenberghe, M. Itala-Remes, J. Y. Cahn, E. Jantunen, W. Schroyens, J. Maertens, A. Esquirol, P. Dreger, S. Montoto, A. Sureda
BONE MARROW TRANSPLANTATION
(2020)
Article
Hematology
Vania Hungria, Meral Beksac, Katja C. Weisel, Ajay K. Nooka, Tamas Masszi, Ivan Spicka, Markus Munder, Maria-Victoria Mateos, Tomer M. Mark, Ming Qi, Xiang Qin, John Fastenau, Andrew Spencer, Pieter Sonneveld, Wendy Garvin, Thomas Renaud, Katharine S. Gries
Summary: In the CASTOR trial, the D-Vd treatment regimen showed significant benefits in extending progression-free survival for RRMM patients, and patient-reported outcomes indicated improvements in health status and pain with long-term daratumumab therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Jerald P. Radich, Andreas Hochhaus, Tamas Masszi, Andrzej Hellmann, Jesper Stentoft, Maria Teresa Gomez Casares, J. Valentin Garcia-Gutierrez, Eibhlin Conneally, Philipp D. le Coutre, Norbert Gattermann, Bruno Martino, Susanne Saussele, Francis J. Giles, David M. Ross, Paola Aimone, Sai Li, Ksenia Titorenko, Giuseppe Saglio
Summary: The ENESTfreedom trial showed that attempting treatment-free remission (TFR) following >3 years of upfront nilotinib therapy in patients with chronic myeloid leukemia in chronic phase (CML-CP) is safe and effective, with some patients being able to maintain TFR status in the long term.
Article
Immunology
Gyorgy Sinkovits, Blanka Mezo, Marienn Reti, Veronika Mueller, Zsolt Ivanyi, Janos Gal, Laszlo Gopcsa, Peter Remenyi, Beata Szathmary, Botond Lakatos, Janos Szlavik, Ilona Bobek, Zita Z. Prohaszka, Zsolt Forhecz, Dorottya Csuka, Lisa Hurler, Erika Kajdacsi, Laszlo Cervenak, Petra Kiszel, Tamas Masszi, Istvan Valyi-Nagy, Zoltan Prohaszka
Summary: Uncontrolled complement activation is associated with advanced disease severity of COVID-19, with patients more likely to die when accompanied by overactivation and consumption of C3. These findings support the potential use of complement inhibitory drugs in the treatment of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Animesh Pardanani, Ayalew Tefferi, Tamas Masszi, Elena Mishchenko, Mark Drummond, Eric Jourdan, Alessandro Vannucchi, Mindaugas Jurgutis, Vincent Ribrag, Alessandro Rambaldi, Liang Piu Koh, Shelonitda Rose, Jun Zhang, Claire Harrison
Summary: Fedratinib, an oral JAK2 inhibitor, showed significant reduction in spleen volume and improvement in symptoms in myelofibrosis patients. The regulatory approval was based on updated data from a phase III trial, demonstrating its efficacy as a first-line treatment option.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Csaba Bodor, Lili Kotmayer, Tamas Laszlo, Ferenc Takacs, Gabor Barna, Richard Kiss, Endre Sebestyen, Tibor Nagy, Lajos Laszlo Hegyi, Gabor Mikala, Sandor Fekete, Peter Farkas, Alexandra Balogh, Tamas Masszi, Judit Demeter, Julia Weisinger, Hussain Alizadeh, Bela Kajtar, Zoltan Kohl, Robert Szasz, Lajos Gergely, Timea Gurbity Palfi, Adrienn Sulak, Balazs Kollar, Miklos Egyed, Mark Plander, Laszlo Rejto, Laszlo Szerafin, Peter Ilonczai, Peter Tamaska, Piroska Pettendi, Dora Levai, Tamas Schneider, Anna Sebestyen, Peter Csermely, Andras Matolcsy, Zoltan Matrai, Donat Alpar
Summary: The study found that the BTKC481S mutation is common in CLL patients and is associated with disease progression, appearing months before clinical relapse symptoms. Subsequent Bcl-2 inhibition therapy in patients with BTKC481S and progressing on ibrutinib treatment resulted in clinical and molecular remission.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Paul G. Richardson, Shaji K. Kumar, Tamas Masszi, Norbert Grzasko, Nizar J. Bahlis, Markus Hansson, Ludek Pour, Irwindeep Sandhu, Peter Ganly, Bartrum W. Baker, Sharon R. Jackson, Anne-Marie Stoppa, Peter Gimsing, Laurent Garderet, Cyrille Touzeau, Francis K. Buadi, Jacob P. Laubach, Michele Cavo, Mohamed Darif, Richard Labotka, Deborah Berg, Philippe Moreau
Summary: The TOURMALINE-MM1 study showed that ixazomib-Rd had a significant improvement in progression-free survival compared to placebo-Rd in relapsed or refractory multiple myeloma patients, but the difference in median overall survival between the two groups was not statistically significant. Subgroup analysis indicated a greater benefit in overall survival for patients with adverse prognostic factors, and a higher percentage of patients in the ixazomib-Rd group received proteasome inhibitors as next-line therapy compared to the placebo-Rd group.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Zoltan Pozsonyi, Gergely Pesko, Hedvig Takacs, Dorottya Csuka, Viktoria Nagy, Agnes Szilagyi, Lidia Hategan, Balazs Muk, Beata Csanyi, Noemi Nyolczas, Livia Dezsi, Judit Maria Molnar, Anita Csillik, Katalin Revesz, Bela Ivanyi, Fruzsina Szabo, Krisztian Birtalan, Tamas Masszi, Zsuzsanna Aranyi, Robert Sepp
Summary: In Hungary, 40 individuals in 23 families with ATTRv were identified, with 24 symptomatic patients. The most common mutations were ATTRHis88Arg and ATTRIle107Val, with restrictive cardiomyopathy and polyneuropathy as the main clinical significant organ involvement.
Article
Oncology
Tara Cochrane, Alicia Enrico, David Gomez-Almaguer, Evgueniy Hadjiev, Ewa Lech-Maranda, Tamas Masszi, Eugene Nikitin, Tadeusz Robak, Robert Weinkove, Shang-Ju Wu, Kavita R. Sail, John Pesko, Madhavi Pai, Viktor Komlosi, Mary Ann Anderson
Summary: The study shows that venetoclax monotherapy has a positive impact on the health-related quality of life of patients with relapsed/refractory CLL, especially in terms of global health status/quality of life. No new safety signals were reported in the study.
LEUKEMIA & LYMPHOMA
(2022)
Article
Hematology
Gyoergy Sinkovits, Marienn Reti, Veronika Mueller, Zsolt Ivanyi, Janos Gal, Laszlo Gopcsa, Peter Remenyi, Beata Szathmary, Botond Lakatos, Janos Szlavik, Ilona Bobek, Zita Z. Prohaszka, Zsolt Foerhecz, Blanka Mezo, Dorottya Csuka, Lisa Hurler, Erika Kajdacsi, Laszlo Cervenak, Petra Kiszel, Tamas Masszi, Istvan Valyi-Nagy, Zoltan Prohaszka
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Fredrik H. Schjesvold, Meletios-Athanasios Dimopoulos, Sosana Delimpasi, Pawel Robak, Daniel Coriu, Wojciech Legiec, Ludek Pour, Ivan Spicka, Tamas Masszi, Vadim Doronin, Jiri Minarik, Galina Salogub, Yulia Alekseeva, Antonio Lazzaro, Vladimir Maisnar, Gabor Mikala, Laura Rosinol, Anna Marina Liberati, Argiris Symeonidis, Victoria Moody, Marcus Thuresson, Catriona Byrne, Johan Harmenberg, Nicolaas A. Bakker, Roman Hajek, Maria-Victoria Mateos, Paul G. Richardson, Pieter Sonneveld
Summary: In patients with relapsed or refractory multiple myeloma, melphalan flufenamide plus dexamethasone demonstrated superior progression-free survival compared to pomalidomide plus dexamethasone.
LANCET HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolett Lupsa, Akos Szegedi, Andras Gezsi, Zoltan Vuncs, Tamas Masszi, Gabor Mikala, Peter Remenyi, Sara Deola, Arun Prasath Lakshmanan, Annalisa Terranegra, Edit Buzas, Zoltan Pos
Summary: This study found a link between low plasma KRT20 levels and moderate to severe aGvHD involving multiple target organs.
Article
Medicine, General & Internal
Apor Hardi, Gergely Varga, Zsolt Nagy, Szabolcs Kosztolanyi, Laszlo Varoczy, Mark Plander, Tamas Schneider, Judit Demeter, Hussain Alizadeh, Arpad Illes, Tamas Masszi, Gabor Mikala
Summary: The study showed that the ixazomib-lenalidomide-dexamethasone triplet is effective for multiple myeloma patients, with some achieving long-term progression-free survival. Side effects were manageable and the treatment was well tolerated by the patients.
Article
Oncology
Gergely Varga, Andras David Toth, Virag Reka Szita, Zoltan Csukly, Apor Hardi, Julia Gaal-Weisinger, Zsolt Nagy, Elvira Altai, Annamaria Rencsik, Mark Plander, Tamas Szendrei, Krisztina Korad, Gaspar Radvanyi, Janos Rottek, Beata Deak, Erika Szaleczky, Tamas Schneider, Zoltan Kohl, Szabolcs Kosztolanyi, Hussain Alizadeh, Zsuzsanna Lengyel, Szabolcs Modok, Zita Borbenyi, Szilvia Lovas, Laszlo Varoczy, Arpad Illes, Peter Rajnics, Tamas Masszi, Gabor Mikala
Summary: In Hungary, lenalidomide-based therapy is only covered for relapsed multiple myeloma patients, typically used as a second-line treatment either in combination with proteasome inhibitors or as a doublet. A study conducted in Hungarian centers found that lenalidomide-dexamethasone treatment had a median progression-free survival of 24 months, with high-risk cytogenetics and number of prior lines being significant independent prognostic factors for PFS. The study also highlighted interesting differences in corticosteroid type and dosing between centers, but outcomes did not vary significantly.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
