Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Article
Oncology
Shelan Rasool, Qais Al Ismaeel, Srdar H. Arif
Summary: This study investigated the expression pattern of matricellular proteins SPARC and CYR61 in colorectal cancer and found their association with cancer progression. High expression of CYR61 was associated with migration, invasion, proliferation, and apoptosis of colorectal cancer cells. This discovery provides new insights for the treatment of colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Huihui Wang, Hao Zhang, Zhirong Sun, Wankun Chen, Changhong Miao
Summary: The research showed that GABABR1 inhibits the migration and invasion of CRC cells by suppressing EMT and the Hippo/YAP1 pathway, indicating that GABABR1 could be a potential therapeutic target for CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Zihong Wu, Qiong Ma, Ying Guo, Fengming You
Summary: This review summarizes the potential molecular mechanisms by which Fusobacterium nucleatum (Fn) promotes the proliferation and migration of colorectal cancer (CRC) cells, such as induction of epithelial-mesenchymal transition, regulation of the tumor microenvironment, expression of oncogenic noncoding RNAs, and DNA damage.
Article
Biochemistry & Molecular Biology
Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Lung cancer metastasis is a major cause of lung cancer-related deaths. This study investigated the potential of cycloartocarpin in inhibiting the metastasis of lung cancer cells. The results showed that non-toxic concentrations of cycloartocarpin effectively suppressed cell migration and attenuated anchorage-independent cell growth. This was accompanied by the inhibition of the EMT process through the suppression of the FAK/AKT signaling pathway.
Article
Pharmacology & Pharmacy
Maha-Hamadien Abdulla, Aminah Ahmad Alzailai, Mansoor-Ali Vaali-Mohammed, Rehan Ahmad, Sabiha Fatima, Ahmed Zubaidi, Thamer bin Traiki, Amer Mahmood, Reem Hamoud Alrashoudi, Zahid Khan
Summary: This study investigated the impact of a novel platinum complex on the invasion and migration of colorectal cancer cell lines. The results showed that the complex reduced cell motility and the expression of EMT markers involved in cell invasion and migration. This complex can potentially be used as an effective treatment for reducing metastasis in colorectal cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cristina Lungulescu, Valentina Ghimpau, Dan Ionut Gheonea, Daniel Sur, Cristian Virgil Lungulescu
Summary: This systematic review investigates the expression and function of neuropilin-2 (NRP-2) in colorectal cancer. The majority of studies suggest that NRP-2 is highly expressed in colorectal cancer cells compared to normal colonic mucosa. The presence of NRP-2 is associated with epithelial-mesenchymal transition and metastatic progression in cancer.
Article
Cell Biology
Wei Liu, Jin Meng, Rongjun Su, Changjun Shen, Shuai Zhang, Yantao Zhao, Wenqi Liu, Jiang Du, Shuai Zhu, Pan Li, Zhigang Wang, Xiaoxia Li
Summary: This study elucidates the mechanism by which long non-coding RNA TUG1 promotes tumor formation in colorectal cancer. SP1 regulates TUG1 and the miR-421/KDM2A/ERK axis, providing novel insights into the development of colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Zhuohan Xin, Keiko Deguchi, Shin-ichiro Suye, Satoshi Fujita
Summary: Metastasis is a common complication of cancer treatment and understanding cell migration is crucial for controlling it. In collective migration, there are leader cells and follower cells, but their interactions are not well understood. The study found that a small number of highly migratory cells can enhance the migration properties of other cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiao Liu, Yu He, Yonghua Tong, Qiu Huang, Haojie Shang, Zhiqiang Chen, Kun Tang
Summary: PODNL1 has been identified as a potential therapeutic target and prognostic biomarker for bladder cancer (BLCA). Its high expression is associated with the clinical and pathological characteristics of BLCA, as well as poor prognosis. It plays a role in regulating the proliferation, migration, and epithelial mesenchymal transition (EMT) process of BLCA cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qiu-di Deng, Xue-Ping Lei, Yi-Hang Zhong, Min-Shan Chen, Yuan-Yu Ke, Zhan Li, Jing Chen, Li-Juan Huang, Yu Zhang, Lu Liang, Zhong-Xiao Lin, Qing Liu, Song-Pei Li, Xi-Yong Yu
Summary: Triptolide derived from Tripterygium wilfordii Hook F inhibits NSCLC metastasis by targeting EMT and reducing beta-catenin expression. In animal models, triptolide suppresses tumor growth, decreases lung metastasis, suggesting its potential therapeutic effect on NSCLC metastasis.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Kittipong Sanookpan, Nongyao Nonpanya, Boonchoo Sritularak, Pithi Chanvorachote
Summary: The study demonstrated that ovalitenone suppresses EMT via inhibition of the AKT/mTOR signaling pathway and has potential for inhibiting CSC phenotypes. These findings reveal the anti-metastasis potential of the compound and support the development of ovalitenone treatment for lung cancer therapy.
Article
Cell Biology
Weiyan Zou, Yi Zhang, Guangfu Bai, Jialu Zhuang, Lin Wei, Zishu Wang, Meiqun Sun, Junbin Wang
Summary: siRNA-induced CD44 knockdown inhibits the biological behaviors of colorectal cancer stem cells (CSCs), including proliferation, migration, invasion, and tumorigenesis. It also promotes apoptosis, induces cell-cycle arrest, increases sensitivity to chemotherapy, and inhibits metastasis by suppressing epithelial-mesenchymal transition (EMT).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)