Gap Junction Intercellular Communication Mediates Ammonia-Induced Neurotoxicity

Gap junction blockers attenuate beta oscillations and improve forelimb function in hemiparkinsonian rats

(2015) Sujoy Phookan et al.   EXPERIMENTAL NEUROLOGY

Refining the Ammonia Hypothesis

(2015) Elliot B. Tapper et al.   MAYO CLINIC PROCEEDINGS

Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1

(2015) Larissa Daniele Bobermin et al.   NEUROTOXICOLOGY

Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death

(2015) Daniela Rossi   PROGRESS IN NEUROBIOLOGY

Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol

(2015) Larissa Daniele Bobermin et al.   TOXICOLOGY IN VITRO

Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways

(2015) Camila Leite Santos et al.   TOXICOLOGY IN VITRO

Functional alterations of astrocytes in mental disorders: pharmacological significance as a drug target

(2015) Yutaka Koyama   Frontiers in Cellular Neuroscience

The dual face of connexin-based astroglial Ca2+ communication: A key player in brain physiology and a prime target in pathology

(2014) Marijke De Bock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

(2014) Boris Görg et al.   GLIA

Guanosine protects C6 astroglial cells against azide-induced oxidative damage: a putative role of heme oxygenase 1

(2014) André Quincozes-Santos et al.   JOURNAL OF NEUROCHEMISTRY

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine

(2014) Roger F. Butterworth   MOLECULAR GENETICS AND METABOLISM

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

(2014) Poonam Thakur et al.   MOLECULAR NEUROBIOLOGY

Hemichannels: new roles in astroglial function

(2014) Juan A. Orellana et al.   Frontiers in Physiology

The Role of Connexin 43 and Hemichannels Correlated with the Astrocytic Death Following Ischemia/Reperfusion Insult

(2013) Xueyu Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hepatic encephalopathy: effects of liver failure on brain function

(2013) Vicente Felipo   NATURE REVIEWS NEUROSCIENCE

Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia

(2013) Qi-ping Dong et al.   NEUROBIOLOGY OF DISEASE

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

(2013) Juan A. Orellana et al.   NEUROPHARMACOLOGY

Lipoic acid protects C6 cells against ammonia exposure through Na+-K+-Cl− co-transporter and PKC pathway

(2013) Larissa Daniele Bobermin et al.   TOXICOLOGY IN VITRO

Gap junctional communication promotes apoptosis in a connexin-type-dependent manner

(2013) P Kameritsch et al.   Cell Death & Disease

Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury

(2013) Lang Zhang et al.   Neuroscience Bulletin

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

(2012) Antonio Currais et al.   ANTIOXIDANTS & REDOX SIGNALING

Paracrine signaling through plasma membrane hemichannels

(2012) Nan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative and nitrosative stress in ammonia neurotoxicity

(2012) Marta Skowrońska et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol Prevents Ammonia Toxicity in Astroglial Cells

(2012) Larissa Daniele Bobermin et al.   PLoS One

Homeostatic function of astrocytes: Ca2+ and Na+ signalling

(2012) Vladimir Parpura et al.   Translational Neuroscience

Glial gap junctional communication involvement in hippocampal damage after middle cerebral artery occlusion

(2011) Minjie Xie et al.   ANNALS OF NEUROLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy

(2011) Kakulavarapu V. Rama Rao et al.   NEUROCHEMISTRY INTERNATIONAL

Differential influence of non-synaptic mechanisms in two in vitro models of epileptic field bursts

(2010) Nikolaj Kraglund et al.   BRAIN RESEARCH

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells

(2010) Kumiko Tanabe et al.   Journal of Neuroinflammation

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Enhanced Glutathione Efflux from Astrocytes in Culture by Low Extracellular Ca2+ and Curcumin

(2010) Malin H. Stridh et al.   NEUROCHEMICAL RESEARCH

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Pharmacological properties of a pore induced by raising intracellular Ca2+

(2009) R.X. Faria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Quantification of gap junctional intercellular communication based on digital image analysis

(2009) Johannes P. Hofgaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Connexin-related signaling in cell death: to live or let die?

(2009) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

Gap junction inhibitors modulate S100B secretion in astrocyte cultures and acute hippocampal slices

(2009) Marina Concli Leite et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Janus Face of Resveratrol in Astroglial Cells

(2009) André Quincozes-Santos et al.   NEUROTOXICITY RESEARCH

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasisin vivo

(2008) Uta Lichter-Konecki et al.   GLIA

Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity

(2008) Tony Kelly et al.   GLIA

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY