Sex, drugs, and trial design: sex influences the heart and drug responses

PDE5 inhibitor efficacy is estrogen dependent in female heart disease

(2014) Hideyuki Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Zolpidem and Driving Impairment — Identifying Persons at Risk

(2013) Ronald H. Farkas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling

(2013) Sara Vandenwijngaert et al.   PLoS One

Should There Be Sex-Specific Criteria for the Diagnosis and Treatment of Heart Failure?

(2013) Lawrence E. Greiten et al.   Journal of Cardiovascular Translational Research

Long-Term Effects of Sildenafil in a Rat Model of Chronic Mitral Regurgitation

(2012) Kyung-Hee Kim et al.   CIRCULATION

Phosphodiesterases and Cyclic GMP Regulation in Heart Muscle

(2012) Dong I. Lee et al.   PHYSIOLOGY

Estrogen Signaling and Cardiovascular Disease

(2011) Elizabeth Murphy   CIRCULATION RESEARCH

Differential Expression of PDE5 in Failing and Nonfailing Human Myocardium

(2011) Xiaoyin Shan et al.   Circulation-Heart Failure

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

(2009) Peter Pokreisz et al.   CIRCULATION

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY