PDE5 inhibitor efficacy is estrogen dependent in female heart disease

Androgen Receptor Promotes Sex-Independent Angiogenesis in Response to Ischemia and Is Required for Activation of Vascular Endothelial Growth Factor Receptor Signaling

(2013) Sumiko Yoshida et al.   CIRCULATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

(2013) Vabren L. Watts et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling

(2013) Sara Vandenwijngaert et al.   PLoS One

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Rapid Estrogen Receptor Signaling Is Essential for the Protective Effects of Estrogen Against Vascular Injury

(2012) Sophie J. Bernelot Moens et al.   CIRCULATION

Long-Term Effects of Sildenafil in a Rat Model of Chronic Mitral Regurgitation

(2012) Kyung-Hee Kim et al.   CIRCULATION

Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women—2011 Update

(2011) Lori Mosca et al.   CIRCULATION

Differential Expression of PDE5 in Failing and Nonfailing Human Myocardium

(2011) Xiaoyin Shan et al.   Circulation-Heart Failure

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

(2011) et al.   EUROPEAN HEART JOURNAL

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

(2010) Ken L. Chambliss et al.   JOURNAL OF CLINICAL INVESTIGATION

A sex-specific role for androgens in angiogenesis

(2010) Daniel P. Sieveking et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myocardial Remodeling Is Controlled by Myocyte-Targeted Gene Regulation of Phosphodiesterase Type 5

(2010) Manling Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway

(2009) Y. Zhou et al.   CARDIOVASCULAR RESEARCH

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

(2009) Peter Pokreisz et al.   CIRCULATION

Phosphodiesterase-5 Inhibitor, Tadalafil, Protects Against Myocardial Ischemia/Reperfusion Through Protein-Kinase G-Dependent Generation of Hydrogen Sulfide

(2009) F. N. Salloum et al.   CIRCULATION

Estrogen Contributes to Gender Differences in Mouse Ventricular Repolarization

(2009) Tomoaki Saito et al.   CIRCULATION RESEARCH

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

(2009) Eiki Takimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the β3-adrenoreceptor

(2009) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart Failure in Women

(2009) Eileen M. Hsich et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The transactivating function 1 of estrogen receptor α is dispensable for the vasculoprotective actions of 17β-estradiol

(2009) Audrey Billon-Galés et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor–Dependent Pathway That Increases Calcineurin Degradation

(2008) Cameron Donaldson et al.   CIRCULATION RESEARCH

Estrogen Inhibits Cardiac Hypertrophy: Role of Estrogen Receptor-β to Inhibit Calcineurin

(2008) Ali Pedram et al.   ENDOCRINOLOGY

17 Beta-Estradiol Differentially Affects Left Ventricular and Cardiomyocyte Hypertrophy Following Myocardial Infarction and Pressure Overload

(2008) Richard D. Patten et al.   JOURNAL OF CARDIAC FAILURE

High blood pressure arising from a defect in vascular function

(2008) S. K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA