Ubiquitin E3 Ligase Itch Negatively Regulates Osteoblast Differentiation from Mesenchymal Progenitor Cells

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease

(2010) Naomi J. Lohr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II

(2010) Hannah J. Durrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation

(2010) Lan Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Smurf control in bone cells

(2010) Lianping Xing et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone

(2010) Heng Zhu et al.   Nature Protocols

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

(2009) MingFang Tao et al.   CURRENT BIOLOGY

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

(2009) Noula Shembade et al.   EMBO JOURNAL

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice

(2009) Heng-Wei Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins

(2008) Ruolin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Itching to end NF-κB

(2008) Vigo Heissmeyer et al.   NATURE IMMUNOLOGY

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

(2008) Noula Shembade et al.   NATURE IMMUNOLOGY