Genetic determinants of hepatic steatosis in man

Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population

(2014) Z. L. Wang et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Pioglitazone in the treatment of NASH: the role of adiponectin

(2010) A. Gastaldelli et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Imaging appearance of severe subcapsular hepatic steatosis: mimicking hepatic embolic infarcts

(2010) M W C H’ng et al.   BRITISH JOURNAL OF RADIOLOGY

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein

(2010) Stefano Romeo et al.   CURRENT OPINION IN LIPIDOLOGY

Dissociation Between Intrahepatic Triglyceride Content and Insulin Resistance in Familial Hypobetalipoproteinemia

(2010) Anastassia Amaro et al.   GASTROENTEROLOGY

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

(2010) P. Dongiovanni et al.   GUT

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

(2010) Nicola Santoro et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency

(2010) Akihiko Kimura et al.   HEPATOLOGY RESEARCH

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specifically PNPLA3-Mediated Accumulation of Liver Fat in Obese Patients with Type 2 Diabetes

(2010) Jean-Michel Petit et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

(2010) Sebastian Zeissig et al.   JOURNAL OF CLINICAL INVESTIGATION

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

(2010) J. Mark Brown et al.   JOURNAL OF LIPID RESEARCH

Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

(2010) Min-Yu Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Medium-chain triglycerides impair lipid metabolism and induce hepatic steatosis in very long-chain acyl-CoA dehydrogenase (VLCAD)-deficient mice

(2010) Sara Tucci et al.   MOLECULAR GENETICS AND METABOLISM

Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

(2010) Kitt Falk Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)

(2010) Silvia Mirandola et al.   Nutrition & Metabolism

Liver disease in pregnancy

(2010) L. Mackillop et al.   POSTGRADUATE MEDICAL JOURNAL

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central players in inherited lipodystrophies

(2010) Ellen H. Jeninga et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Outcome After Liver Transplantation for NASH Cirrhosis

(2009) S. M. Malik et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation ofde novofatty acids1

(2009) Marie Akkaoui et al.   BIOCHEMICAL JOURNAL

Lipodystrophies: Disorders of adipose tissue biology

(2009) Abhimanyu Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

(2009) Paulina Pettinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

(2009) Víctor A. Cortés et al.   Cell Metabolism

Variable phenotypic expression of homozygous familial hypobetalipoproteinaemia due to novel APOB gene mutations

(2009) E Di Leo et al.   CLINICAL GENETICS

Future Challenges for Microsomal Transport Protein Inhibitors

(2009) Anthony Wierzbicki et al.   Current Vascular Pharmacology

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

(2009) J. L. Estall et al.   DIABETES

The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease

(2009) Stergios A. Polyzos et al.   DIABETES OBESITY & METABOLISM

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts

(2009) Anna Kotronen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans

(2009) Dae Won Jun et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Genetics of Common Obesity and Nonalcoholic Fatty Liver Disease

(2009) Elizabeth K. Speliotes   GASTROENTEROLOGY

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Luca Valenti et al.   GASTROENTEROLOGY

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

(2009) Koji Fujita et al.   HEPATOLOGY

Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease

(2009) Masato Yoneda et al.   HEPATOLOGY RESEARCH

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins

(2009) B. Kollerits et al.   HUMAN MOLECULAR GENETICS

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonsynonymous Mutations withinAPOBin Human Familial Hypobetalipoproteinemia

(2009) Shumei Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminopathies and the long strange trip from basic cell biology to therapy

(2009) Howard J. Worman et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease

(2009) Katsutoshi Tokushige et al.   JOURNAL OF GASTROENTEROLOGY

Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease

(2009) Claudia Pinto Marques Souza Oliveira et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Combined hyperlipidaemia as a presenting sign of cholesteryl ester storage disease

(2009) S. Decarlis et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

A common variant in the adiponutrin gene influences liver enzyme values

(2009) B. Kollerits et al.   JOURNAL OF MEDICAL GENETICS

Lipoprotein metabolism mediates the association of MTP polymorphism with β-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis

(2009) Giovanni Musso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Microsomal triglyceride transfer protein polymorphism (−493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C

(2009) Silvia Mirandola et al.   LIVER INTERNATIONAL

Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease

(2009) Masato Yoneda et al.   LIVER INTERNATIONAL

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Subcutaneous and visceral adipose tissue: structural and functional differences

(2009) M. Mohsen Ibrahim   Obesity Reviews

Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver Disease

(2009) Y.-C. Lin et al.   PEDIATRICS

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperferritinemia is a risk factor for steatosis in chronic liver disease

(2009) Anna Licata et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Liver disease in pregnancy

(2009) Noel M Lee et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

(2008) Masato Yoneda et al.   BMC GASTROENTEROLOGY

The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women

(2008) Yangsoo Jang et al.   CLINICA CHIMICA ACTA

A novel missense LIPA gene mutation, N98S, in a patient with cholesteryl ester storage disease

(2008) Amanda J. Hooper et al.   CLINICA CHIMICA ACTA

Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia

(2008) Shoji Katsuda et al.   CLINICA CHIMICA ACTA

TheDGAT2gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

(2008) Konstantinos Kantartzis et al.   CLINICAL SCIENCE

Variability and Function of Family 1 Uridine-5′-Diphosphate Glucuronosyltransferases (UGT1A)

(2008) Christian P. Strassburg et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

New approaches to target microsomal triglyceride transfer protein

(2008) Mohammed Mahmood Hussain et al.   CURRENT OPINION IN LIPIDOLOGY

Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease

(2008) Silvia Sookoian et al.   CYTOKINE

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity

(2008) Lovisa E Johansson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice

(2008) Kengo Tomita et al.   HEPATOLOGY

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Visceral fat: A key mediator of steatohepatitis in metabolic liver disease

(2008) David van der Poorten et al.   HEPATOLOGY

Ethnic differences in hepatic steatosis: An insulin resistance paradox?

(2008) Richard Guerrero et al.   HEPATOLOGY

The C-terminal Region of Human Adipose Triglyceride Lipase Affects Enzyme Activity and Lipid Droplet Binding

(2008) Martina Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Metabolism in Patients with PPARγ Mutations

(2008) Garry D. Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people

(2008) Vincent Wai-Sun Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio

(2008) Shaohua Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease

(2008) Michiharu Komatsu et al.   JOURNAL OF HEPATOLOGY

Identification of 13 novel mutations including a retrotransposal insertion in SLC25A13 gene and frequency of 30 mutations found in patients with citrin deficiency

(2008) Ayako Tabata et al.   JOURNAL OF HUMAN GENETICS

Wolman disease/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice

(2008) Hong Du et al.   JOURNAL OF LIPID RESEARCH

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH

Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease

(2008) Silvia Sookoian et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients

(2008) R. Zampino et al.   JOURNAL OF VIRAL HEPATITIS

Nuclear receptors, mitochondria and lipid metabolism

(2008) William A. Alaynick   MITOCHONDRION

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

(2008) Frederick F Samaha et al.   Nature clinical practice. Cardiovascular medicine

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY

The HFE gene heterozygosis H63D: a cofactor for liver damage in patients with steatohepatitis? Epidemiological and clinical considerations

(2007) S. Neri et al.   INTERNAL MEDICINE JOURNAL