CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle

(2011) P. Dent et al.   MOLECULAR INTERVENTIONS

Alternative splicing of SYK regulates mitosis and cell survival

(2011) Panagiotis Prinos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies

(2010) Paula M. Fracasso et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Chk1 inhibitor Gö6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo

(2010) Zizhen Feng et al.   CANCER LETTERS

Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF- B Pathway and Generation of Reactive Oxygen Species

(2010) Y. Jin et al.   CANCER RESEARCH

Targeting the checkpoint kinase Chk1 in cancer therapy

(2010) Callie Merry et al.   CELL CYCLE

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

(2010) Y. Dai et al.   CLINICAL CANCER RESEARCH

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

(2010) Hiroyuki Niida et al.   EMBO JOURNAL

Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 Substrate

(2010) Xianwen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

(2010) F Al-Ejeh et al.   ONCOGENE

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents

(2010) S Zenvirt et al.   ONCOGENE

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion

(2009) Tracy Layton et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

(2009) R. Beckerman et al.   GENES & DEVELOPMENT

Stem-like Cancer Cells Are Inducible by Increasing Genomic Instability in Cancer Cells

(2009) Yi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology

(2009) Stephen Caldwell et al.   JOURNAL OF GASTROENTEROLOGY

Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells

(2009) X. Zhang et al.   MOLECULAR CANCER RESEARCH

Tumor Suppressor Function of Syk in Human MCF10A In Vitro and Normal Mouse Mammary Epithelium In Vivo

(2009) You Me Sung et al.   PLoS One

GSK-3β Targets Cdc25A for Ubiquitin-Mediated Proteolysis, and GSK-3β Inactivation Correlates with Cdc25A Overproduction in Human Cancers

(2008) Tiebang Kang et al.   CANCER CELL

Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma

(2008) Satoru Ogane et al.   INTERNATIONAL JOURNAL OF CANCER

TULA proteins regulate activity of the protein tyrosine kinase Syk

(2008) Rachana Agrawal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE