Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

DNA Repair Proteins as Molecular Targets for Cancer Therapeutics

(2012) Mark Kelley et al.   Anti-Cancer Agents in Medicinal Chemistry

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Loss of 53BP1 Is a Gain for BRCA1 Mutant Cells

(2010) Elizabeth M. Kass et al.   CANCER CELL

Inactivation of DNA-Dependent Protein Kinase Leads to Spindle Disruption and Mitotic Catastrophe with Attenuated Checkpoint Protein 2 Phosphorylation in Response to DNA Damage

(2010) Zeng-Fu Shang et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Decision at the break point

(2010) Simon J. Boulton   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

Role of senescence and mitotic catastrophe in cancer therapy

(2010) Richa Singh et al.   Cell Division

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts

(2009) C. Zhang et al.   CLINICAL CANCER RESEARCH

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of Drug-Induced Mitotic Catastrophe in Cancer Cells

(2009) Jose Portugal et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting the DNA damage response for cancer therapy

(2009) Simon N. Powell et al.   DNA REPAIR

Validation of the Royal Marsden Hospital Prognostic Index in Advanced Esophagogastric Cancer Using Individual Patient Data From the REAL 2 Study

(2009) Ian Chau et al.   JOURNAL OF CLINICAL ONCOLOGY

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

(2009) Isabelle Robert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

(2009) V. Lafarga et al.   MOLECULAR AND CELLULAR BIOLOGY

Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy

(2009) Yingmei Wang et al.   Molecular Cancer

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

(2009) L. A. Parsels et al.   MOLECULAR CANCER THERAPEUTICS

APOMAB®, a La-Specific Monoclonal Antibody, Detects the Apoptotic Tumor Response to Life-Prolonging and DNA-Damaging Chemotherapy

(2009) Fares Al-Ejeh et al.   PLoS One

Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

(2009) George Iliakis   RADIOTHERAPY AND ONCOLOGY

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells

(2008) Benjamin Thierry et al.   ADVANCED MATERIALS

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Apoptosis and non-apoptotic deaths in cancer development and treatment response

(2008) Elza C. de Bruin et al.   CANCER TREATMENT REVIEWS

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45

(2008) R Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia

(2008) E. Willmore et al.   CLINICAL CANCER RESEARCH

DNA Damage Detection and Repair Pathways--Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

(2008) S. Ashwell et al.   CLINICAL CANCER RESEARCH

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

(2008) B. Evers et al.   CLINICAL CANCER RESEARCH

p53: A Guide to Apoptosis

(2008) Erik Meulmeester et al.   CURRENT CANCER DRUG TARGETS

DNA Damage Repair and Response Proteins as Targets for Cancer Therapy

(2008) Howard Lieberman   CURRENT MEDICINAL CHEMISTRY

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2

(2008) Wenqi Wu et al.   DNA REPAIR

Cleavage-mediated Activation of Chk1 during Apoptosis

(2008) Kenkyo Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

(2008) A. Blasina et al.   MOLECULAR CANCER THERAPEUTICS

What drives success for specialty pharmaceuticals?

(2008) Mark Gudiksen et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway

(2007) Marc Audebert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS