PI3k/AKT signaling pathway: Erythropoiesis and beyond

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

(2018) Justin Kale et al.   EMBO REPORTS

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

(2017) Alex RD Delbridge et al.   Cell Death & Disease

Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells

(2017) Huicong Yang et al.   Oncology Letters

From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals

(2017) Martina Moras et al.   Frontiers in Physiology

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

A comparative study of the characterization of miR-155 in knockout mice

(2017) Dong Zhang et al.   PLoS One

Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease

(2016) Raymond Liang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening

(2016) Baobing Zhao et al.   DEVELOPMENTAL CELL

Erythrocyte survival is controlled by microRNA-142

(2016) Natalia Rivkin et al.   HAEMATOLOGICA

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis

(2016) Takuya Kamio et al.   PLoS One

The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer

(2016) Yan Dai et al.   Oncotarget

Erythrocyte survival is controlled by microRNA-142

(2016) Natalia Rivkin et al.   HAEMATOLOGICA

The Erythropoietin Receptor

(2016) Stephanie S. Watowich   JOURNAL OF INVESTIGATIVE MEDICINE

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy

(2015) Xinlei Yu et al.   Autophagy

Autophagy as a Regulatory Component of Erythropoiesis

(2015) Jieying Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erythropoietin activates the phosporylated cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury

(2015) Joshua M. Mares et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis

(2014) Xin Zhang et al.   AMERICAN JOURNAL OF HEMATOLOGY

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

(2014) Cristina Mammucari et al.   Autophagy

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice

(2014) E. P. Lu et al.   BLOOD

MIR144andMIR451regulate human erythropoiesis via RAB14

(2014) MinJung Kim et al.   BRITISH JOURNAL OF HAEMATOLOGY

A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation

(2014) Takashi Moriguchi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Erythropoiesis from Human Embryonic Stem Cells Through Erythropoietin-Independent AKT Signaling

(2014) William S. Kim et al.   STEM CELLS

Autophagy facilitates organelle clearance during differentiation of human erythroblasts

(2013) Virginie M.S. Betin et al.   Autophagy

miR-320a regulates erythroid differentiation through MAR binding protein SMAR1

(2013) Smriti P.K. Mittal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study

(2013) Maria Trincavelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Arginine Methyltransferase 1 Interacts with and Activates p38α to Facilitate Erythroid Differentiation

(2013) Wei-Kai Hua et al.   PLoS One

MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

(2013) Valentina Lulli et al.   PLoS One

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

(2012) Jingyi Zhou et al.   Autophagy

Integrating novel signaling pathways involved in erythropoiesis

(2012) Evan Ingley   IUBMB LIFE

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

(2012) E. H. Bresnick et al.   NUCLEIC ACIDS RESEARCH

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transcription factor networks in erythroid cell and megakaryocyte development

(2011) L. C. Dore et al.   BLOOD

Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway

(2011) Valya Ramakrishnan et al.   BLOOD CELLS MOLECULES AND DISEASES

Expression of miR-210 during erythroid differentiation and induction of γ-globin gene expression

(2011) Nicoletta Bianchi et al.   BMB Reports

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

The role of the GATA2 transcription factor in normal and malignant hematopoiesis

(2011) Carmen Vicente et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Life and death of transcriptional co-activator p300

(2011) Jihong Chen et al.   Epigenetics

MicroRNAs: Allies or Foes in erythropoiesis?

(2011) John C.H. Byon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy Driven by a Master Regulator of Hematopoiesis

(2011) Y.-A. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis

(2011) Imane Azzouzi et al.   PLoS One

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

(2011) V. G. Sankaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

miR-451 protects against erythroid oxidant stress by repressing 14-3-3 

(2010) D. Yu et al.   GENES & DEVELOPMENT

Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex

(2010) M. Gabbianelli et al.   HAEMATOLOGICA

Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression

(2009) Y. Cheng et al.   GENOME RESEARCH

MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis

(2009) N. Felli et al.   HAEMATOLOGICA

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2

(2008) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells

(2008) H. Zhao et al.   BLOOD

miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2

(2008) L. Pase et al.   BLOOD

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function

(2008) Z WEI et al.   CELLULAR SIGNALLING

Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells

(2008) Silvia Missiroli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY