Fenretinide Induces Ubiquitin-Dependent Proteasomal Degradation of Stearoyl-CoA Desaturase in Human Retinal Pigment Epithelial Cells

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

Fenretinide Ameliorates Insulin Resistance and Fatty Liver in Obese Mice

(2012) In-uk Koh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

INVESTIGATION OF ORAL FENRETINIDE FOR TREATMENT OF GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION

(2012) Nathan L. Mata et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells

(2011) Hae Sun Park et al.   BIOCHEMICAL PHARMACOLOGY

Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells

(2011) Daniel Hess et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Identification of Dihydroceramide Desaturase as a Directin VitroTarget for Fenretinide

(2011) Mehrdad Rahmaniyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Dihydroceramide Desaturase by PalmitateversusMonounsaturated Fatty Acids

(2011) Wei Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Unknown

(2011) Sara Garcia-Serrano et al.   MOLECULAR MEDICINE

Metabolic Changes in Skin Caused by Scd1 Deficiency: A Focus on Retinol Metabolism

(2011) Matthew T. Flowers et al.   PLoS One

Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging

(2010) Judith H. Ford   AGE

Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch?

(2010) Pawel Dobrzyn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

(2010) G. W. Xu et al.   BLOOD

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

The Retinal Pigment Epithelium in Health and Disease

(2010) J. R. Sparrrow et al.   CURRENT MOLECULAR MEDICINE

Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery

(2010) J Mark Brown et al.   CURRENT OPINION IN LIPIDOLOGY

Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity ofN-(4-Hydroxyphenyl)retinamide in Tumor Cells

(2010) Zhehao Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

Unknown

(2010) Antero Salminen et al.   MOLECULAR MEDICINE

Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells

(2010) Daniel Hess et al.   PLoS One

Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice

(2009) Makoto Miyazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

(2009) A. Peter et al.   DIABETES

Stearoyl-CoA desaturase inhibitors: update on patented compounds

(2009) Gang Liu   EXPERT OPINION ON THERAPEUTIC PATENTS

Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2  (eIF2 )-Kinase (PERK) and General Control Nonderepressible-2 eIF2  Kinase (GCN2), and Global Translational Shutoff

(2009) P. Acharya et al.   MOLECULAR PHARMACOLOGY

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

(2008) Andreas Peter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity

(2008) Roslyn Dillon et al.   ANALYTICA CHIMICA ACTA

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Experimental and Computational Studies Investigating Trehalose Protection of HepG2 Cells from Palmitate-Induced Toxicity

(2007) Sukit Leekumjorn et al.   BIOPHYSICAL JOURNAL