Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity ofN-(4-Hydroxyphenyl)retinamide in Tumor Cells

Fenretinide induces autophagic cell death in caspase-defective breast cancer cells

(2014) Barbara Fazi et al.   Autophagy

Substrate Specificity, Membrane Topology, and Activity Regulation of Human Alkaline Ceramidase 2 (ACER2)

(2010) Wei Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-chain Ceramides, and Its Down-regulation Inhibits Both Cell Proliferation and Apoptosis

(2010) Wei Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G

(2009) Takayuki Noda et al.   APOPTOSIS

Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells

(2009) Numsen Hail et al.   APOPTOSIS

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells

(2009) Paola Signorelli et al.   CANCER LETTERS

Oral Fenretinide in Biochemically Recurrent Prostate Cancer: A California Cancer Consortium Phase II Trial

(2009) Eric Cheung et al.   Clinical Genitourinary Cancer

Involvement of Rac in Fenretinide-Induced Apoptosis

(2008) H. Kadara et al.   CANCER RESEARCH

Alkaline ceramidase 2 regulates β1 integrin maturation and cell adhesion

(2008) Wei Sun et al.   FASEB JOURNAL

De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma

(2008) Geraldine Rath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

(2008) Susanne Schiffmann et al.   JOURNAL OF LIPID RESEARCH

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Upregulation of the Human Alkaline Ceramidase 1 and Acid Ceramidase Mediates Calcium-Induced Differentiation of Epidermal Keratinocytes

(2007) Wei Sun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY