Review
Biochemistry & Molecular Biology
Young Seok Cho
Summary: Genipin, extracted from Gardenia fruits, is a protein cross-linking agent with antioxidant, anticancer properties. It inhibits UCP2 and MMP-2, and induces cancer cell apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chen Feng, Etienne Empweb Anger, Xiong Zhang, Shengdi Su, Chenlin Su, Shuxin Zhao, Feng Yu, Ji Li
Summary: This study suggests that UCP2 may protect HK-2 cells from the toxicity induced by AA I, and reduce the toxicity by decreasing oxidative stress and apoptosis. UCP2 could be a potential target for alleviating AA I-induced nephrotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Fukui Shen, Wen Yang, Kaixue Zhang, Yanting Jiao, Jing Cui, Yuanyuan Hou, Gang Bai
Summary: Mitochondria play a vital role in eukaryotic life by providing energy through metabolism. Excessive mitochondrial hyperthermia and reactive oxygen species (ROS) production are associated with various diseases. A UCP2 inhibitor called genipin (GNP) is being studied for its effects on mitochondrial temperature, but its mechanisms are not well understood. This study developed molecular probes to investigate the interactions between GNP and UCP2. The results showed that the hemiacetal structure in GNP selectively reacts with lysine in the UCP2 proton leakage channel, leading to inhibition of mitochondrial thermogenesis.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
David F. Carrageta, Lais Freire-Brito, Barbara Guerra-Carvalho, Joao C. Ribeiro, Bruno S. Monteiro, Alberto Barros, Pedro F. Oliveira, Mariana P. Monteiro, Marco G. Alves
Summary: UCPs play a crucial role in regulating mitochondrial activity and ROS production. The expression and function of UCPs in human spermatozoa have been investigated, providing valuable insights into the mechanisms of male infertility.
Article
Critical Care Medicine
Liang Zhao, Lulu Sun, Xiafei Li, Tian Lu, Yuxue Pan, Pengchong Du
Summary: This study elucidated the cardioprotective mechanism of genipin and demonstrated its potential for treating ischemic heart failure.
Article
Endocrinology & Metabolism
Zhijuan Ge, Yue Shang, Wendie Wang, Jigang Yang, Shu-Zhen Chen
Summary: The study investigated the effects of brown adipocytes on the proliferation and migration of NB cells in a co-culture system. The results showed that brown adipocytes promoted the proliferation and migration of NB cells and the UCP2 and PPAR-gamma pathways were involved in this process.
Article
Biochemistry & Molecular Biology
Mingliang Zhang, Liming Wang, Dejia Wen, Changjie Ren, Shuang Chen, Zhihui Zhang, Lanlan Hu, Zihao Yu, Joyce Tombran-Tink, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable
Summary: Caffeic acid phenylethyl ester (CAPE) protects retinal ganglion cells from ischemic injury, exhibits antioxidant properties, and functions through modulation of the mitochondrial uncoupling protein UCP2.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Sanja Skulj, Zlatko Brkljaca, Jurgen Kreiter, Elena E. Pohl, Mario Vazdar
Summary: Molecular dynamics simulations of uncoupling proteins present a challenge due to the lack of available structural data. In this study, a combination of homology modelling and MD simulations of UCP2 revealed a structure impermeable to water. Additionally, results from conductance measurements in model membranes suggest that the UCP2 structure modeled from ANT protein possesses key functional elements related to proton transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Alena A. Nikanorova, Nikolay A. Barashkov, Vera G. Pshennikova, Nyurgun N. Gotovtsev, Georgii P. Romanov, Aisen Solovyev, Sargylana S. Kuzmina, Nikolay N. Sazonov, Sardana A. Fedorova
Summary: This study investigates the relationship between uncoupling protein genes and irisin levels in the Yakut population of Siberia. The findings suggest a significant association between the UCP3 gene variant rs1800849 and elevated irisin levels, as well as reduced weight and height in females. Furthermore, the distribution frequency of this allele is higher in northern Asian populations compared to southern populations.
Article
Cell Biology
Seyma Calis, Berna Dogan, Serdar Durdagi, Asuman Celebi, Ozlem Yapicier, Turker Kilic, Eda Tahir Turanli, Timucin Avsar
Summary: A novel 4-thiazolidinone derivative BH3 mimetic, BAU-243, has been found to effectively reduce GBM cell proliferation and trigger autophagic cell death. Compared to other drugs, BAU-243 shows superior anti-tumor effects in orthotopic brain tumor models.
CELL DEATH DISCOVERY
(2022)
Article
Physiology
Tomas A. Schiffer, Liza Loef, Radiosa Gallini, Masood Kamali-Moghaddam, Mattias Carlstroem, Fredrik Palm
Summary: The study reveals a dynamic interaction between ANT2 and UCP2 that is regulated by mitochondrial respiratory activity, potentially impacting mitochondrial efficiency and cellular substrate utilization.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tala Shekarian, Carl P. Zinner, Ewelina M. Bartoszek, Wandrille Duchemin, Anna T. Wachnowicz, Sabrina Hogan, Manina M. Etter, Julia Flammer, Chiara Paganetti, Tomas A. Martins, Philip Schmassmann, Steven Zanganeh, Francois Le Goff, Manuele G. Muraro, Marie-Francoise Ritz, Darci Phillips, Salil S. Bhate, Graham L. Barlow, Garry P. Nolan, Christian M. Schuerch, Gregor Hutter
Summary: This study demonstrated that ex vivo immunotherapy of GBM explants can induce an active antitumoral immune response within the tumor center, providing a framework for multidimensional personalized assessment of tumor response to immunotherapy.
Article
Biochemistry & Molecular Biology
Yang Xu, Fanen Yuan, Qian Sun, Linyao Zhao, Yu Hong, Shiao Tong, Yangzhi Qi, Liguo Ye, Ping Hu, Zhang Ye, Si Zhang, Baohui Liu, Qianxue Chen
Summary: RNA-binding protein CSTF2 is upregulated in human glioblastoma (GBM) and promotes GBM cell survival by binding to the mRNA of the BAD protein to shorten its 3' UTR, resulting in the destabilization of BAD mRNA and inhibition of BAD-mediated apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Jing-Ying Chen, Ying-Sui Sun, Diem Thuy Nguyen, Chia-Fei Liu, Her-Hsiung Huang
Summary: Zirconia (ZrO2) is widely used in dental implants due to its good mechanical properties, but its bioinert nature may hinder osseointegration. Immobilization of BMP-2 on sandblasted ZrO2 surfaces using genipin increased surface roughness and improved focal adhesion activation and mineralization of hMSCs. Low and high concentrations of BMP-2 did not significantly affect later-stage osteogenic response, but low BMP-2 concentration stimulated early-stage osteogenic markers and p38 protein expression on ZrO2 surfaces.
MATERIALS & DESIGN
(2022)
Article
Cell Biology
Maurizio Forte, Franca Bianchi, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Vittorio Maglione, Sebastiano Sciarretta, Valentina Valenti, Roberto Carnevale, Francesco Versaci, Giacomo Frati, Massimo Volpe, Speranza Rubattu
Summary: UCP2 plays a protective role in high-salt-induced oxidative stress and autophagy, preserving the viability of endothelial and renal tubular cells. Excessive ROS accumulation upon UCP2 silencing and high-salt exposure inhibits autophagy, while an exogenous autophagy inducer can rescue cellular damage.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Mohammad Mehdi Jahani, Azita Azimi Meibody, Talie Karimi, Mohammad Mehdi Banoei, Massoud Houshmand
MITOCHONDRIAL DNA PART A
(2020)
Article
Endocrinology & Metabolism
Kazem Vatankhah Yazdi, Seyed Mehdi Kalantar, Massoud Houshmand, Masoud Rahmanian, Masoud Reza Manaviat, Mohammad Reza Jahani, Behnam Kamalidehghan, Amir Almasi-Hashiani
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Immunology
Susan Nabilou, Fatemeh Pak, Zahra Alizadeh, Mohammad Reza Fazlollahi, Masoud Houshmand, Maryam Ayazi, Iraj Mohammadzadeh, Mohammad Hasan Bemanian, Abbas Fayezi, Mohammad Nabavi, Shiva Saghafi, Sajedeh Mohammadian, Parviz Kokhaei, Mostafa Moin, Zahra Pourpak
Summary: This study aimed to define the genetic spectrum of HAE type I and type II among Iranian patients. Mutations in SERPING1 were analyzed using PCR and Sanger Sequencing, leading to the identification of 14 pathogenic variations, including 3 novel mutations. Genetic diagnosis plays a significant role in early diagnosis and prevention of potential risks associated with HAE.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Letter
Immunology
Zahra Alizadeh, Susan Nabilou, Marzieh Mazinani, Shaghayegh Tajik, Amir Ali Hamidieh, Masoud Houshmand, Mohammad Reza Fazlollahi, Zahra Pourpak
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hormoz Selahvarzi, Milad Kamdideh, Mehrnoosh Vahabi, Ali Dezhgir, Massoud Houshmand, Soha Sadeghi
Summary: This study identified a significant relationship between two polymorphisms, Rs1544410 and rs4646536, in the VDR and CYP27B1 genes and an increased risk of developing vitamin D3 insufficiency in the Iranian population. These SNPs can be considered as prognostic biomarkers for the risk of vitamin D3 deficiency.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Allergy
Leila Shakerian, Maryam Nourizadeh, Mohsen Badalzadeh, Mohammad Reza Fazlollahi, Raheleh Shokouhi Shoormasti, Shiva Saghafi, Behnaz Esmaeili, Zahra Alizadeh, Stephan Borte, Massoud Houshmand, Lennart Hammarstrom, Zahra Pourpak
Summary: This study investigated the alterations of TREC and KREC biomarkers in 82 PID patients with different genetic diagnoses, and found a significant difference in both markers compared to age-matched healthy controls. Patients with CVID, AT, WAS, DOCKS deficiency, and HIES with unknown genetic defects showed very low to zero amounts of TREC and/or KREC, while STAT3-deficient patients were normal for both biomarkers.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rezvan Abtahi, Parvaneh Karimzadeh, Alireza Rezayi, Shadab Salehpour, Diba Akbarzadeh, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh, Massoud Houshmand
Summary: The study provided additional insights into the genotype of sphingolipidoses diseases among Iranian patients, identifying novel mutations and expanding the genotypic spectrum for MLD, SD, TSD, and NPD disorders. This research can potentially lead to the development of more effective methods for genetic carrier detection, diagnosis, and counseling of affected Iranian patients.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Oncology
Atefeh Zamani, Nasrin Fattahi Dolatabadi, Massoud Houshmand, Nasrinsadat Nabavizadeh
Summary: The study identified miR-324-3p and miR-5085p as potential regulators of ABCA3 expression in childhood ALL, with low expression in pediatric ALL patients compared to non-cancer controls. MiR-508-5p showed promise as a relapsed indicator in childhood ALL, potentially influencing novel therapeutic strategies and acting as a diagnostic and drug-resistant biomarker.
Article
Multidisciplinary Sciences
Parisa Veiskarami, Massoud Houshmand, Sharareh Seifi, Nafiseh Ansarinejad, Farshid Fardad, Bahareh Abbasi
Summary: The study revealed a significant association between the CHRNA3 rs1051730C > T variant and the risk of developing lung cancer, as well as nicotine dependence in the Iranian population. However, no association was found for the ABCB1 rs3842A > G variant. These results suggest that the CHRNA3 rs1051730C > T variant may modify susceptibility to lung cancer among Iranians through a smoking-dependent mechanism.
Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Virology
Peyman Taghizadeh, Sadegh Salehi, Ali Heshmati, Seyed Massoud Houshmand, Kolsoum InanlooRahatloo, Forouzandeh Mahjoubi, Mohammad Hossein Sanati, Hadi Yari, Afagh Alavi, Saeid Amel Jamehdar, Soroosh Dabiri, Hamid Galehdari, Mohammad Reza Haghshenas, Amir Masoud Hashemian, Abtin Heidarzadeh, Issa Jahanzad, Elham Kheyrani, Ahmad Piroozmand, Ali Mojtahedi, Hadi Razavi Nikoo, Mohammad Masoud Rahimi Bidgoli, Nayebali Rezvani, Mehdi Sepehrnejad, Arash Shakibzadeh, Gholamreza Shariati, Noorossadat Seyyedi, Seyed MohammadSaleh Zahraei, Iman Safari, Elahe Elahi
Summary: The study identified different haplotypes and variants among COVID-19 infected individuals in Iran, with H1a and H1b haplotypes being the most prevalent, indicating a significant change in infection pattern over time. Additionally, a considerable proportion of samples were speculated to have recombinant genomes and co-infections, with co-existing viruses being related to those currently circulating in Iran.
Article
Genetics & Heredity
Rezvan Abtahi, Parvaneh Karimzadeh, Omid Aryani, Diba Akbarzadeh, Shadab Salehpour, Alireza Rezayi, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh, Massoud Houshmand
Summary: In this study, genetic analysis was performed on Iranian patients with Niemann-Pick disease type C (NPC), resulting in the identification of 10 novel mutations and determination of their pathogenicity. These findings will facilitate future prenatal diagnosis.
Article
Genetics & Heredity
Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand
Summary: This study aims to evaluate the frequency of three clinically significant CYP2B6 polymorphisms in three major Iranian ethnicities. The results show that Kurds have a higher risk of adverse drug reactions and insufficient anti-HIV response compared to other Iranians.
Article
Genetics & Heredity
Behnaz Hamzei, Toktam Sheidaeian, Neghar Bahadorzehi, Parvin Sheibani, Marzie Akbari, Sahar Akbari, Samere Gholizade, Marjan Sadat Tabatabae, Nasrin Fattahi Dolatabadi, Fariborz Kianpour, Mitra Heidarpour, Masoud Houshmand, Atefeh Zamani, Hossein Tabatabaeian
Article
Biochemistry & Molecular Biology
Zahra Nourolahzadeh, Massoud Houshmand, Fawzia Mostafa Mohammad, Saeed Ghorbian
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)