Article
Biochemistry & Molecular Biology
Yue Wang, Xin-yan Liu, Yue Wang, Wen-xin Zhao, Fa-dong Li, Peng-rong Guo, Qian Fan, Xiao-fan Wu
Summary: This study investigated the latent mechanism of NOX2-triggered vulnerable plaque development. The results showed that the NOX2-specific inhibitor GSK2795039 can prevent the formation of vulnerable plaques and enhance macrophage efferocytosis by regulating the MertK/PI3K/AKT pathway.
Article
Pharmacology & Pharmacy
Muhammed Ikbal Sonmez, Andleeb Shahzadi, Cagla Kose, Haktan Sonmez, Sibel Ozyazgan, Ahmet Gokhan Akkan
Summary: Sulfasalazine reduces endothelial dysfunction induced by high glucose by activating eNOS, enhancing the antioxidant effect of HO-1 enzymes, and inducing Nrf2 via the ERK and JNK pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Weihua Shao, Suxing Wang, Xiaoxi Wang, Lixia Yao, Xiaoye Yuan, Dai Huang, Bonan Lv, Yuquan Ye, Hongyuan Xue
Summary: miR-29a is found to play a crucial role in the development of atherosclerosis (AS). It has been discovered that miR-29a regulates autophagy by targeting the PI3K/AKT/mTOR pathway. This finding highlights the potential of miR-29a as a novel therapeutic strategy for AS.
Article
Biochemistry & Molecular Biology
Xuan Wu, Yuhong Luo, Shan Wang, Yueying Li, Meiyu Bao, Yuanjiang Shang, Lei Chen, Weiwei Liu
Summary: This study demonstrates the protective role of AKAP12 in acute liver injury and chronic liver fibrosis, at least partially through inhibition of the PI3K/AKT/PCSK6 pathway. These findings provide a new potential treatment for liver injury and have important clinical implications.
Article
Immunology
Zun Pan Fan, Mei Lin Peng, Yuan Yao Chen, Yu Ze Xia, Chun Yan Liu, Kai Zhao, Hui Ping Zhang
Summary: S100A9 in testicular macrophages plays a crucial role in maintaining their immunosuppressive function through the activation of the PI3K/Akt pathway. Treatment with S100A9 promotes the polarization of macrophages from M0 to M2, and elevated S100A9 following UPEC infection helps maintain the M2 polarization of testicular macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaodi Liu, Wenyue Zhang, Yanni Xu, Xiaolin Xu, Qiongchao Jiang, Jingliang Ruan, Ye Wu, Yingshi Zhou, Phei Er Saw, Baoming Luo
Summary: Residual tumors after insufficient radiofrequency ablation (IRFA) exhibit accelerated progression and anti-PD-1 resistance, with reports indicating that macrophages infiltrating into these tumors may be a contributing factor. The involvement of autophagic elements, particularly LC3, in residual tumors is being investigated to understand the mechanisms between LC3 and macrophages, aiming to enhance immunotherapy for these tumors.
Article
Pharmacology & Pharmacy
Chenpei Zhao, Huan Chen, Hao Liang, Xiaoyu Zhao, Wenli Tang, Maolian Wei, Youzhi Li, Jianlong Zhang, Xin Yu, Guozhong Chen, Hongwei Zhu, Linlin Jiang, Xingxiao Zhang
Summary: Probiotic Lactobacillus plantarum RS-09 has been found to modulate M1 macrophage polarization and induce TLR2-linked NF-kappa B signaling activity, enhancing the immune response against Salmonella Typhimurium infection. Additionally, RS-09 relieves splenomegaly, body weight loss, and death rate associated with the infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yanjing Li, Yuanlin Tang, Sirong Shi, Shaojingya Gao, Yun Wang, Dexuan Xiao, Tianyu Chen, Qing He, Junjiang Zhang, Yunfeng Lin
Summary: The study demonstrates that tFNAs can improve hepatic insulin resistance by activating the IRS-1/PI3K/Akt pathway, leading to increased glucose uptake, promoted hepatic cell proliferation, reduced cell apoptosis, and lowered blood glucose levels in a T2DM mouse model. This highlights the potential application of tFNAs in improving T2DM through the PI3K/Akt pathway.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Hairong Zhao, Jiaming Lu, Furong He, Mei Wang, Yunbo Yan, Binyang Chen, De Xie, Chenxi Xu, Qiang Wang, Weidong Liu, Wei Yu, Yuemei Xi, Linqian Yu, Tetsuya Yamamoto, Hidenori Koyama, Wei Wang, Chenggui Zhang, Jidong Cheng
Summary: This study reveals that hyperuricemia impairs glucose tolerance in hepatic macrophages, leading to insulin resistance and inhibition of IRS2-proteasome degradation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Claudia Lennicke, Helena M. Cocheme
Summary: The study found that oxidants, especially H2O2, can mimic the effects of insulin. Increasing intracellular H2O2 levels affects signaling and amplifies insulin-mediated cellular responses. Specific molecular targets of insulin-stimulated H2O2 include phosphatases and kinases, whose activity is altered through redox modifications.
Article
Multidisciplinary Sciences
Tao Zou, Shan Gao, Zhaolan Yu, Fuyong Zhang, Lan Yao, Mengyao Xu, Junxin Li, Zhigui Wu, Yilan Huang, Shurong Wang
Summary: Salvianolic acid B (Sal B) inhibits the polarization of M1 macrophages by promoting autophagy via the NF-kappa B signalling pathway, thus exhibiting anti-atherosclerotic effects.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jingbin Xu, Henggui Xu, Kexin Ma, Yue Wang, Ben Niu, Li Zhang, Fasheng Li
Summary: This study investigated the biological effects and mechanisms of lncRNA in PM2.(5)-induced changes in macrophage polarity, and revealed that lncRNA lncGm16410 suppresses PM2.(5)-induced macrophage activation via the SRC protein-mediated PI3K/AKT signaling pathway, potentially offering new insights into preventing PM2.(5) injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qichen He, Bo Chen, Gang Wang, Duanfang Zhou, Hongfang Zeng, Xiaoli Li, Yi Song, Xiaoping Yu, Wenxin Liang, Huiling Chen, Xu Liu, Qiuya Wu, Lihong Wu, Limei Zhang, Huizhen Li, Xiangnan Hu, Weiying Zhou
Summary: This study found that the co-crystal of rosiglitazone with berberine (RB) can improve hyperglycemia and insulin resistance in high-sugar high-fat diet-induced diabetic mice. The mechanism of action may be through regulating the PI3K/AKT/TXNIP signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou
Summary: CTGF promotes intercellular communication in chondrocytes through upregulating Cx43 expression and activating the PI3K/Akt signaling pathway.
CELL PROLIFERATION
(2021)
Article
Microbiology
Xia Yu, Guirong Wang, Suting Chen, Guomei Wei, Yuanyuan Shang, Lingling Dong, Thomas Schon, Danesh Moradigaravand, Julian Parkhill, Sharon J. Peacock, Claudio U. Koser, Hairong Huang
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Computer Science, Artificial Intelligence
Xiuzhuang Zhou, Yuanyuan Shang, Haibin Yan, Guodong Guo
INFORMATION FUSION
(2016)
Article
Engineering, Multidisciplinary
Min Xu, Yuanyuan Shang
MATHEMATICAL PROBLEMS IN ENGINEERING
(2016)
Article
Computer Science, Artificial Intelligence
Xiuzhuang Zhou, Lin Ma, Yuanyuan Shang, Min Xu, Xiaoyan Fu, Hui Ding
Article
Computer Science, Artificial Intelligence
Yuanyuan Shang, Ge Li, Zhong Luan, Xiuzhuang Zhou, Guodong Guo
Article
Computer Science, Artificial Intelligence
Xiuzhuang Zhou, Haibin Yan, Yuanyuan Shang
Article
Computer Science, Artificial Intelligence
Xiuzhuang Zhou, Qirun Huo, Yuanyuan Shang, Min Xu, Hui Ding
IMAGE AND VISION COMPUTING
(2017)
Article
Computer Science, Artificial Intelligence
Zhong Luan, Yuanyuan Shang, Xiuzhuang Zhou, Zhuhong Shao, Guodong Guo, Xiaoming Liu
Article
Immunology
Xinmiao Jia, Li Yang, Mengxing Dong, Suting Chen, Lingna Lv, Dandan Cao, Jing Fu, Tingting Yang, Ju Zhang, Xiangli Zhang, Yuanyuan Shang, Guirong Wang, Yongjie Sheng, Hairong Huang, Fei Chen
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Oncology
Yuan-Yuan Shang, Ning-Ning Fang, Feng Wang, Hui Wang, Zhi-Hao Wang, Meng-Xiong Tang, Jie Peng, Yun Zhang, Wei Zhang, Ming Zhong
MOLECULAR MEDICINE REPORTS
(2015)
Article
Computer Science, Interdisciplinary Applications
Lin Zhang, Yuanyuan Shang, Ying Huang, Gunnar Sivertsen
Summary: The study found that male reviewers dominate in almost all countries, regions, and research fields. Male reviewers generally contribute to review work more frequently than females, but female reviewers write longer reviews. The correlations between reviewing activity and research activity are generally weak, indicating that active reviewers are not necessarily the most productive researchers in their fields.
Article
Computer Science, Interdisciplinary Applications
Yuanyuan Shang, Gunnar Sivertsen, Zhe Cao, Lin Zhang
Summary: This study explores gender balance and differences among first authors within SDG5 oriented research during the first 5 years after the implementation of SDG5 in 2016. The findings show that compared to other SDGs, the field of SDG5 produces fewer scientific publications, but with a higher proportion of female first authors. Male and female first authors focus on partly different topics, and potential readers show more interest in publications by female first authors. This investigation highlights the importance of increasing gender diversity in SDG5-related studies for achieving sustainable development.
Article
Information Science & Library Science
Lin Zhang, Yuanyuan Shang, Ying Huang, Gunnar Sivertsen
Summary: Over the past forty years, Mainland China's social science research has significantly internationalized, with an increase in articles published in international journals, expanding collaboration networks among researchers, and a steady rise in appearances in high impact journals. Different social science disciplines show varying degrees of internationalization.
QUANTITATIVE SCIENCE STUDIES
(2021)
Review
Cardiac & Cardiovascular Systems
Guokai Shang, Xinyan Yang, Daijun Song, Yun Ti, Yuanyuan Shang, Zhihao Wang, Mengxiong Tang, Yun Zhang, Wei Zhang, Ming Zhong
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Yuanyuan Shang, Yue Meng
PROCEEDINGS OF INTERNATIONAL CONFERENCE ON ARTIFICIAL LIFE AND ROBOTICS (ICAROB2015)
(2015)