Article
Andrology
Jia Xu, Chao He, Yi-Wei Fang, Zhi-Yong Hu, Mei-Lin Peng, Yuan-Yao Chen, Yu-Fang Su, Chun-Yan Liu, Hui-Ping Zhang, Kai Zhao
Summary: Male reproductive infections affect testicular immune balance leading to infertility. This study investigates the immunomodulatory properties of exosomes released in the inflammatory environment and identifies the role of miR-155-5p in orchitis.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Veterinary Sciences
Larena Reifarth, Hanna Koerber, Eva-Maria Packeiser, Sandra Goericke-Pesch
Summary: Chronic asymptomatic idiopathic orchitis (CAO) is an overlooked cause of male infertility in dogs, and similarities with human diseases suggest that dogs could serve as a valuable model for studying spermatogenesis and stem cells. This study examined the expression of specific proteins in healthy and CAO-affected dog testes, finding significant reductions in protein levels associated with CAO. Despite this disruption, putative stem cells with self-renewal and differentiation capabilities were still present, suggesting the potential for stem cell-based therapies to restore fertility in CAO-affected dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Oncology
Cong Li, Shi Qiu, Kun Jin, Xiaonan Zheng, Xianghong Zhou, Di Jin, Binghe Xu, Xun Jin
Summary: The study revealed that tumor cells in triple-negative breast cancer can release microparticles loaded with PD-L1, leading to tumor progression. These PD-L1-loaded microparticles can suppress the activation and function of immune cells through various mechanisms.
Article
Urology & Nephrology
Sarah Marie Norton, Alex Saies, Eva Browne, Beatrice Charambra, David Silviu, Nauman Nabi, Girish Nama, Subhasis Giri, Hugh D. Flood
Summary: Acute epididymo-orchitis (AEO) is a common urological condition characterized by pain and swelling of the epididymis. The study found that AEO can lead to testicular atrophy and loss in some patients.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Nanoscience & Nanotechnology
Kun Jiang, Xueyu Wen, Torbjoern Pettersson, Thomas Crouzier
Summary: This study aimed to transfer the bioactivity of three-dimensional Muc-gels to the surface of two model materials by immobilizing mucin into thin films (Muc-film). The results showed that Muc-film on soft polyacrylamide gels mimicked the immune-modulating properties of Muc-gel in regulating macrophage responses. However, Muc-film on hard polystyrene had a different effect compared to Muc-gel.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Yongbin Xu, Qun Wang, Jie Chen, Jianjun Wu, Juan Su, Wei Gao, Weihao Chen, Songshan Shi, Shunchun Wang, Huijun Wang
Summary: An arabinogalactan (PTPS-1-2) was isolated from Pollen Typhae and investigated for its potential antitumor effects on activating macrophages and promoting apoptosis in colorectal cancer cells. The structural characterization revealed the composition of PTPS-1-2 and its activation of the NF-kB signaling pathway. The conditioned medium from PTPS-1-2 treated macrophages demonstrated significant antitumor effects on inhibiting cancer cell proliferation.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Oncology
Eleonora Timperi, Paul Gueguen, Martina Molgora, Ilaria Magagna, Yann Kieffer, Silvia Lopez-Lastra, Philemon Sirven, Laura G. Baudrin, Sylvain Baulande, Andre Nicolas, Gabriel Champenois, Didier Meseure, Anne Vincent-Salomon, Anne Tardivon, Enora Laas, Vassili Soumelis, Marco Colonna, Fatima Mechta-Grigoriou, Sebastian Amigorena, Emanuela Romano
Summary: This study identifies a novel lipid-associated macrophage subpopulation with immune suppressive functions and provides new leads for therapeutic interventions in triple-negative breast cancer.
Article
Chemistry, Medicinal
Seungjin Jeong, Mi-Bo Kim, Suhyeon Baek, Joowon Lee, Hyeju Lee, Bei Cao, Yongeun Kim, Lei Cao, Sanggil Lee
Summary: Macrophages are important in chronic inflammatory diseases, and this study found that SHE and its Hex fraction inhibit LPS-induced inflammation and oxidative stress by modulating the polarization of macrophages.
Article
Multidisciplinary Sciences
Baisui Feng, Lingzhi Xu, Shuo Song, Huazhen Liu, Yan Li, Suqin Hu, Qing Shu, Jiangqi Liu, Zhiqiang Liu, Haiqiong Yu, Pingchang Yang
Summary: The impaired immune regulatory function of M4 cells obtained from UC patient colon lavage fluid (CLF) was characterized in this study. M4s were the most abundant cellular components in CLF (21.3 4.0%). The M2 M4s (M2 cells) from the ulcerative colitis (UC) group showed weaker immune suppressive function and lower abundance. High levels of endoplasmic reticulum (ER) stress associated molecules were detected in UC M2 cells. XBP1 promoted the expression of Rnf20 in M2 cells. Rnf20 reduced PD-L1 abundance in UC M2 cells and impaired the immune suppressive ability. Inhibition of Rnf20 restored the immune regulating capacity of M2 cells and suppressed experimental colitis.
Article
Engineering, Biomedical
Nicole B. Day, Rianne Dalhuisen, Nichole E. Loomis, Sarah G. Adzema, Jai Prakash, C. Wyatt Shields
Summary: This study describes a tissue-adhesive hydrogel system that can regulate the release of drugs independent of its bulk properties. The release mechanism is mediated by microparticles with defined crosslink densities. By encapsulating different drugs into the particles, multimodal drug release can be achieved. The system demonstrates capabilities of sustained polarization of immune cells and transdermal drug delivery, with implications in treating various skin disorders, managing infections, and delivering vaccines.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Yizhe Sun, Yue Yin, Lidong Gong, Zichao Liang, Chuanda Zhu, Caixia Ren, Nan Zheng, Qiang Zhang, Haibin Liu, Wei Liu, Fuping You, Dan Lu, Zhiqiang Lin
Summary: Interferon (IFN) responses are crucial for host defense against coronavirus and other viruses. A nanodepot of manganese (nanoMn) based on Mn2+ was successfully fabricated using chemical engineering strategy, enhancing cellular uptake and persistent release of Mn2+ in a pH-sensitive manner, thereby strengthening IFN responses and eliciting broad-spectrum antiviral effects.
Article
Reproductive Biology
C. Proebstl, A. Umbach, A. Beineke, H. Koerber, S. Goericke-Pesch
Summary: Spontaneous autoimmune orchitis (AIO) in dogs is a significant cause of male infertility, characterized by histopathological damage of testicular tissue and infiltration of immune cells. Our study revealed the presence of all investigated immune cell types in AIO samples but limited immune cell presence in healthy control samples. The pathogenesis of canine AIO involves interactions between macrophages, T lymphocytes, and plasma cells. Testicular biopsies are an important tool for diagnosing spontaneous AIO.
Review
Immunology
Shuo Ni, Yin Yuan, Yanbin Kuang, Xiaolin Li
Summary: This article discusses the role of iron in immune regulation, particularly in macrophage polarization, T-cell activation, and B-cell antibody response. It also explores the correlations between iron and diseases such as cancer and aging degenerative diseases, as well as therapeutic strategies targeting those diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nataliya V. Mushenkova, Nikita G. Nikiforov, Alexandra A. Melnichenko, Vladislav Kalmykov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Alexander N. Orekhov
Summary: This review discusses the functional phenotypes of intraplaque macrophages and their distinct contribution to atherosclerosis inflammation.
Article
Environmental Sciences
Zhiyong Hu, Liting He, Jiajing Wei, Yufang Su, Wei Wang, Zunpan Fan, Jia Xu, Yuan Zhang, Yongfeng Wang, Meilin Peng, Kai Zhao, Huiping Zhang, Chunyan Liu
Summary: Triclocarban (TCC) exposure was found to increase tmbim4 gene expression in zebrafish embryos, resulting in higher susceptibility to TCC-induced embryonic death in tmbim4 mutant embryos. Knockout of the tmbim4 gene affects the autophagy pathway, leading to abnormal accumulation of autophagosomes and increased apoptosis in hindbrain of tmbim4 mutant zebrafish embryos exposed to TCC. Pretreatment with autophagosome formation inhibitors reduced mortality and apoptosis levels in TCC-exposed tmbim4 mutant zebrafish embryos. Defects in the tmbim4 gene reduce zebrafish embryo resistance to TCC, with apoptosis induced by abnormal accumulation of autophagosomes playing a role in this process.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Yufang Su, Liting He, Zhiyong Hu, Ying Li, Yuan Zhang, Zunpan Fan, Kai Zhao, Huiping Zhang, Chunyan Liu
Summary: Obesity alters testicular microbiota composition, which may be linked to decreased sperm motility in obese men.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Yongfeng Wang, Zhiquan Yu, Zunpan Fan, Yiwei Fang, Liting He, Meili Peng, Yuanyao Chen, Zhiyong Hu, Kai Zhao, Huiping Zhang, Chunyan Liu
Summary: The study revealed that the antibacterial pesticide Mancozeb has cardiotoxic effects on zebrafish larvae, possibly by activating NOTCH and apoptosis-related signaling pathways leading to pericardial edema, myocardial fibrosis, and congestion in the heart area. This finding provides important insights into understanding the cardiotoxicity induced by Mancozeb.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Zunpan Fan, Yunyi Yang, Peixuan Hu, Yaochen Huang, Liting He, Rui Hu, Kai Zhao, Huiping Zhang, Chunyan Liu
Summary: This study aimed to investigate the cardiotoxicity effects of Ethylparaben (EP) on zebrafish embryo development. The results showed that EP exposure caused abnormal cardiac function and morphology in zebrafish embryos, and further research revealed that EP exposure led to cardiac morphologic abnormalities through disruption of the retinoic acid signaling pathway, inhibition of gene expression related to myocardial contraction, and orientation development disturbance of heart tube. This study lays the foundation for further understanding the toxicity of EP on embryonic development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)