MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

(2016) Antonio Castro-Castro et al.   Annual Review of Cell and Developmental Biology

RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs

(2016) Hiroaki Kajiho et al.   EMBO REPORTS

TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

(2016) Clément Chevalier et al.   Nature Communications

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

(2015) A. S. Coates et al.   ANNALS OF ONCOLOGY

A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness

(2015) Minsoo Koh et al.   INTERNATIONAL JOURNAL OF CANCER

Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis

(2015) T. Baldassarre et al.   MOLECULAR CANCER RESEARCH

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

(2015) C Lodillinsky et al.   ONCOGENE

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-β signaling in nasopharyngeal carcinoma

(2015) Sumei Cao et al.   Oncotarget

Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β

(2015) Liang Zhao et al.   Oncotarget

Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways

(2015) Jie Liu et al.   Scientific Reports

Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas

(2014) Ksenia A Arkhipova et al.   BMC CANCER

RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

(2014) Direna Alonso-Curbelo et al.   CANCER CELL

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

(2014) Emanuela Frittoli et al.   JOURNAL OF CELL BIOLOGY

Flotillins in intercellular adhesion - from cellular physiology to human diseases

(2014) S. Bodin et al.   JOURNAL OF CELL SCIENCE

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

(2014) I. R. Macpherson et al.   JOURNAL OF CELL SCIENCE

Flotillin-1 expression in human clear-cell renal cell carcinoma is associated with cancer progression and poor patient survival

(2014) YIYAN ZHANG et al.   Molecular Medicine Reports

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

(2014) C. Rosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of flotillin-2 is associated with renal cell carcinoma progression

(2014) Yang Yan et al.   TUMOR BIOLOGY

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion

(2013) Elena Rainero et al.   BIOESSAYS

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

Flotillin microdomains stabilize cadherins at cell-cell junctions

(2013) E. Guillaume et al.   JOURNAL OF CELL SCIENCE

Flotillin-2 is associated with breast cancer progression and poor survival outcomes

(2013) Xi Wang et al.   Journal of Translational Medicine

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flotillin2 Expression Correlates with HER2 Levels and Poor Prognosis in Gastric Cancer

(2013) Zhi Zhu et al.   PLoS One

High Expression of FLOT1 Is Associated with Progression and Poor Prognosis in Hepatocellular Carcinoma

(2013) Shi-Hong Zhang et al.   PLoS One

Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer

(2013) Hui Li et al.   TUMOR BIOLOGY

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

(2012) Xinzi Yu et al.   JOURNAL OF CELL BIOLOGY

P-cadherin is a direct PAX3–FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness

(2012) S Thuault et al.   ONCOGENE

Flotillins as regulators of ErbB2 levels in breast cancer

(2012) S Pust et al.   ONCOGENE

Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

(2012) T Berger et al.   ONCOGENE

Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan

(2012) Sara Sigismund et al.   PHYSIOLOGICAL REVIEWS

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Knockdown of FLOT1 Impairs Cell Proliferation and Tumorigenicity in Breast Cancer through Upregulation of FOXO3a

(2011) C. Lin et al.   CLINICAL CANCER RESEARCH

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Phosphorylation of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and Its Vesicle-associated Membrane Protein 7 (VAMP7)-dependent Trafficking Facilitate Cell Invasion and Migration

(2011) Karla C. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The roles of flotillin microdomains - endocytosis and beyond

(2011) G. P. Otto et al.   JOURNAL OF CELL SCIENCE

Secretory and endo/exocytic trafficking in invadopodia formation: The MT1-MMP paradigm

(2010) Emanuela Frittoli et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

(2010) Daniel Williamson et al.   JOURNAL OF CLINICAL ONCOLOGY

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes

(2010) Susanne Cornfine et al.   MOLECULAR BIOLOGY OF THE CELL

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

(2010) L. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating ECM Barriers at the Invasive Front: The Cancer Cell–Stroma Interface

(2009) R. Grant Rowe et al.   Annual Review of Cell and Developmental Biology

Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells

(2009) H. Yamaguchi et al.   CANCER RESEARCH

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

Basolateral Internalization of GPI-anchored Proteins Occurs via a Clathrin-independent Flotillin-dependent Pathway in Polarized Hepatic Cells

(2009) Tounsia Aït-Slimane et al.   MOLECULAR BIOLOGY OF THE CELL

RhoE controls myoblast alignment prior fusion through RhoA and ROCK

(2008) M Fortier et al.   CELL DEATH AND DIFFERENTIATION

MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7

(2008) Anika Steffen et al.   CURRENT BIOLOGY

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE