Article
Geriatrics & Gerontology
Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perie, Jean Lacau St-Guily, Aurelien Corneau, Gillian Butler-Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet
Summary: This study explored the role of nonmyogenic cells (fibroadipogenic progenitors, FAPs) in human fibrotic muscles and found that FAPs from fibrotic muscles have a higher proliferation rate compared to those from nonfibrotic muscles, which leads to impaired fusion index when cocultured with muscle cells. The study also identified endothelin as a potential target to counteract human muscle fibrosis through a paracrine signaling pathway.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Biochemistry & Molecular Biology
Yi Sun, Minmin Lyu, Qiuji Lu, Kenneth Cheung, Victor Leung
Summary: There is growing evidence linking intervertebral disc degeneration (IDD) and increased fibrotic elements in the nucleus pulposus (NP), including enhanced matrix turnover, abnormal deposition of collagens and other fibrous matrices, emergence of fibrosis effector cells, and upregulation of fibroinflammatory factors. Studies suggest that NP cells play a role in fibroblastic differentiation through the TGF-beta R1-Smad2/3 pathway, inflammatory activation, and mechanosensing. Abnormal MMP activity is also associated with NP fibrosis. MMP-2 and MMP-12 are the main markers of fibroblastic NP cells. This review aims to classify the biochemical features and molecular identity of fibroblastic cells in the context of IDD, providing new insights into its pathomechanism and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joshua M. Peterson, Jayson W. Jay, Ye Wang, Alejandro A. Joglar, Anesh Prasai, Alen Palackic, Steven E. Wolf, Amina El Ayadi
Summary: Galunisertib, an inhibitor of ALK5, has anti-fibrotic effects on dermal fibroblasts and enhances in vitro wound closure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang
Summary: The study demonstrated that simultaneous use of PRP and suramin promoted myoblast proliferation, reduced fibronectin expression, and decreased fibronectin expression at the site of muscle injury. In the animal study, the group treated with PRP plus suramin showed better muscle healing and contractile strength compared to the group treated with PRP alone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Geriatrics & Gerontology
Linyuan Shen, Tianci Liao, Qiuyang Chen, Yuhang Lei, Linghui Wang, Hao Gu, Yanhao Qiu, Ting Zheng, Yiting Yang, Chenggang Wei, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Yan Zhu, Mingzhou Li, Jinyong Wang, Xuewei Li, Mailin Gan, Li Zhu
Summary: This study explores the role of tRNA-derived small RNAs (tsRNAs), specifically 5'tiRNA-Gly, in skeletal muscle regeneration. It is found that 5'tiRNA-Gly is significantly up-regulated after muscle injury and promotes inflammation through the TGF-beta signaling pathway. These findings provide a new potential target for skeletal muscle regeneration treatment.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Pharmacology & Pharmacy
David Dolivo, Pamela Weathers, Tanja Dominko
Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Cell Biology
Laxmansa C. Katwa, Chelsea Mendoza, Madison Clements
Summary: Cardiovascular disease is the leading cause of death worldwide, and patients with cardiovascular diseases are more susceptible to severe complications of COVID-19. The role of cardiac myofibroblasts in both COVID-19-induced cardiac injury and healing process is crucial.
Article
Biochemistry & Molecular Biology
Jaime Gutierrez, David Gonzalez, Rodrigo Escalona-Rivano, Chiaki Takahashi, Enrique Brandan
Summary: RECK plays a role as a potential myogenic repressor during muscle formation and regeneration, with transient up-regulation accelerating muscle regeneration. RECK-deficient mice show reduced fibrosis in a model of chronic muscle damage, suggesting RECK as a potential target for treating muscle-wasting diseases.
Review
Biochemistry & Molecular Biology
Elena Ortiz-Zapater, Jaime Signes-Costa, Paula Montero, Ines Roger
Summary: Fibrosis in the lungs is a growing clinical problem that leads to shortness of breath and respiratory failure. It can be caused by various diseases such as idiopathic pulmonary fibrosis, asthma, COPD, allergies, and infection clearance. This review discusses the different types of fibrosis, the main cells involved, and the mechanisms of fibrosis. It also highlights current treatments and potential targets for anti-fibrotic therapies.
Article
Cell Biology
Davi A. G. Mazala, Ravi Hindupur, Young Jae Moon, Fatima Shaikh, Iteoluwakishi H. Gamu, Dhruv Alladi, Georgiana Panci, Michele Weiss-Gayet, Benedicte Chazaud, Terence A. Partridge, James S. Novak, Jyoti K. Jaiswal
Summary: Lack of dystrophin expression is the genetic basis for Duchenne muscular dystrophy (DMD), and disease severity varies due to genetic modifiers. The D2-mdx model exhibits severe muscle degeneration and poor regeneration in juvenile stage, resulting from an enhanced inflammatory response and excessive accumulation of fibroadipogenic progenitors (FAPs). However, in adult D2-mdx muscle, the extent of damage and degeneration decreases, associated with restoration of inflammatory and FAP responses, leading to improved regenerative myogenesis. Therefore, targeting aberrant stromal cell responses may provide therapeutic benefits for DMD treatment.
CELL DEATH DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Eigo Ikushima, Shin Ishikane, Takehiro Kishigami, Hiroaki Matsunaga, Kazunobu Igawa, Katsuhiko Tomooka, Yosuke Nishimura, Fumi Takahashi-Yanaga
Summary: 2,5-dimethylcelecoxib (DM-C) attenuates fibroblast-to-myofibroblast transformation (FMT) and decreases cardiac fibrosis by inhibiting the TGF-beta signaling pathway through activation of GSK-3.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Xia Guo, Oluwaseun Adeyanju, Christudas Sunil, Venkatakirankumar Mandlem, Ayobami Olajuyin, Steven Huang, Shi-You Chen, Steven Idell, Torry A. Tucker, Guoqing Qian
Summary: DOCK2 plays a crucial role in pulmonary fibrosis by modulating FMT, with its upregulation dependent on TGF-beta induction and Smad3, ERK pathways, and contributing to the changes in lung fibroblast phenotypes.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Cheng, Fei Xue, Cheng Cheng, Wenhai Sui, Meng Zhang, Lei Qiao, Jing Ma, Xiaoping Ji, Wenqiang Chen, Xiao Yu, Bo Xi, Feng Xu, Guohai Su, Yuxia Zhao, Panpan Hao, Yun Zhang, Cheng Zhang
Summary: ADAM17 knockdown alleviates cardiac fibrosis in diabetic mice by regulating ACE2 shedding and myofibroblast transformation through the TGF-beta 1/Smad3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Anirban Roy, Tatiana E. Koike, Aniket S. Joshi, Meiricris Tomaz da Silva, Kavya Mathukumalli, Mingfu Wu, Ashok Kumar
Summary: This study investigates the impact of TAK1 on the progression of muscular dystrophy in mdx mouse model of DMD. The results suggest that TAK1 promotes muscle growth and inhibits necrosis, demonstrating its potential as a therapeutic target for DMD.
Review
Cell Biology
Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri, Charles K. Thodeti
Summary: The review discusses the mechanism of fibrosis and proposes TRPV4 as a potential therapeutic target for the condition, highlighting the need for specific drugs in the treatment of fibrosis.
Article
Biochemistry & Molecular Biology
Jan P. Wintgens, Sven P. Wichert, Luksa Popovic, Moritz J. Rossner, Michael C. Wehr
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Immunology
Nicholas N. Jarjour, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Irina Shchukina, Chih-Chung Lin, Stanley Ching-Cheng Huang, Chin-Wen Lai, Melissa E. Cook, Reshma Taneja, Thaddeus S. Stappenbeck, Gwendalyn J. Randolph, Maxim N. Artyomov, Joseph F. Urban, Brian T. Edelson
Correction
Biochemistry & Molecular Biology
Jan P. Wintgens, Sven P. Wichert, Luksa Popovic, Moritz J. Rossner, Michael C. Wehr
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Rene Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A-Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J. Rossner, Michael H. Sieweke, Melanie Greter, Robert Mansson, Meinrad Busslinger, Taras Kreslavsky
Article
Biochemistry & Molecular Biology
Jasmine Lye Yee Yap, Yee Kit Tai, Juerg Frohlich, Charlene Hui Hua Fong, Jocelyn Naixin Yin, Zi Ling Foo, Sharanya Ramanan, Christian Beyer, Shi Jie Toh, Marco Casarosa, Narendra Bharathy, Monica Palanichamy Kala, Marcel Egli, Reshma Taneja, Chuen Neng Lee, Alfredo Franco-Obregon
Article
Immunology
Chaofan Li, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, Kathryn E. Beckermann, Yue Wu, James W. Jenkins, Peter J. Siska, Benjamin G. Vincent, Y. S. Prakash, Tobias Peikert, Brian T. Edelson, Reshma Taneja, Mark H. Kaplan, Jeffrey C. Rathmell, Haidong Dong, Taro Hitosugi, Jie Sun
Article
Biochemistry & Molecular Biology
Hsin Yao Chiu, Emmy Xue Yun Tay, Derrick Sek Tong Ong, Reshma Taneja
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Biochemistry & Molecular Biology
Dhanasekan Karthigeyan, Arnab Bose, Ramachandran Boopathi, Vinay Jaya Rao, Hiroki Shima, Narendra Bharathy, Kazuhiko Igarashi, Reshma Taneja, Arun Kumar Trivedi, Tapas K. Kundu
JOURNAL OF BIOCHEMISTRY
(2020)
Article
Hematology
Clint Piper, Vivian Zhou, Richard Komorowski, Aniko Szabo, Benjamin Vincent, Jonathan Serody, Maria-Luisa Alegre, Brian T. Edelson, Reshma Taneja, William R. Drobyski
Article
Immunology
Nicholas N. Jarjour, Tara R. Bradstreet, Elizabeth A. Schwarzkopf, Melissa E. Cook, Chin-Wen Lai, Stanley Ching-Cheng Huang, Reshma Taneja, Thaddeus S. Stappenbeck, Steven J. Van Dyken, Joseph F. Urban, Brian T. Edelson
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Stefanie Ohlig, Solene Clavreul, Manja Thorwirth, Tatiana Simon-Ebert, Riccardo Bocchi, Sabine Ulbricht, Nirmal Kannayian, Moritz Rossner, Swetlana Sirko, Pawel Smialowski, Judith Fischer-Sternjak, Magdalena Goetz
Summary: Astrocytes exhibit diverse gene expression states related to distinct functions, with some subsets being more widespread while others are regionally restricted. The study also reveals the novel concept of low-level proliferation of astrocytes in the adult diencephalon, with Smad4 identified as a key regulator.
Review
Biochemistry & Molecular Biology
Alexander Herholt, Vivek K. Sahoo, Luksa Popovic, Michael C. Wehr, Moritz J. Rossner
Summary: Next-generation sequencing has led to the development of many analysis techniques for transcriptomics and genomics, while the concept of 'molecular barcoding' has further expanded the sequencing-based applications. Reporter barcodes allow for quantitative monitoring of biological events, providing insights into complex cellular signaling.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Cell Biology
Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Summary: Compared with SOX10 alone, the combination of SON increases the number of induced oligodendrocytes (iOLs) and enhances their complexity and myelin-marker gene expression levels. RNA velocity analysis shows that SOX10 generates OPCs that are apparently more immature than those generated by SON, with distinct molecular properties.
Article
Psychiatry
Marius Stephan, Jonathan Schoeller, Florian J. Raabe, Andrea Schmitt, Alkomiet Hasan, Peter Falkai, Niels Jensen, Moritz J. Rossner
Summary: In this study, we found that spironolactone and aripiprazole improve cognitive deficits related to schizophrenia, but interfere with each other's effects in combination therapy. Additionally, aripiprazole may increase negative valence measures as a side effect.