Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays

Lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer: A systematic review


(2018) Rebecca Madden et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts

(2018) Sabrina Galinski et al.   Scientific Reports

The efficacy of lapatinib and capecitabine in HER-2 positive breast cancer with brain metastases: A systematic review and pooled analysis

(2017) Fausto Petrelli et al.   EUROPEAN JOURNAL OF CANCER

Split protein biosensor assays in molecular pharmacological studies

(2016) Michael C. Wehr et al.   DRUG DISCOVERY TODAY

Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins

(2016) Tom Ronan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR

(2015) Debjit Basu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

(2014) Julia Petschnigg et al.   NATURE METHODS

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

(2013) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

The SH2 Domain Interaction Landscape

(2013) Michele Tinti et al.   Cell Reports

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

(2013) Ryan C. Elkins et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane

(2012) D. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An improved bimolecular fluorescence complementation tool based on superfolder green fluorescent protein

(2011) Jun Zhou et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

(2011) Viktorija Velanac et al.   GLIA

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

A public genome-scale lentiviral expression library of human ORFs

(2011) Xiaoping Yang et al.   NATURE METHODS

Imidazo[2,1-b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases

(2010) Steve D. Fidanze et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases

(2010) Gary T. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Inhibition of Tumor Cell Growth, Invasion, and Metastasis by EXEL-2880 (XL880, GSK1363089), a Novel Inhibitor of HGF and VEGF Receptor Tyrosine Kinases

(2009) F. Qian et al.   CANCER RESEARCH

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

(2009) Mark J Mulvihill et al.   Future Medicinal Chemistry

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

(2009) Wenjun Zhou et al.   NATURE

Statistical methods for analysis of high-throughput RNA interference screens

(2009) Amanda Birmingham et al.   NATURE METHODS

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV

(2008) Michael C Wehr et al.   BMC BIOTECHNOLOGY

The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2

(2008) Stefan Hanke et al.   MOLECULAR & CELLULAR PROTEOMICS