Impact of genetic insights into calpain biology

DNA damage response links calpain to cellular senescence

(2011) Francesca Demarchi et al.   CELL CYCLE

Translocation of the Cytoplasmic Domain of ADAM13 to the Nucleus Is Essential for Calpain8-a Expression and Cranial Neural Crest Cell Migration

(2011) Hélène Cousin et al.   DEVELOPMENTAL CELL

Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1

(2011) K. Tonami et al.   JOURNAL OF CELL SCIENCE

Non-Proteolytic Functions of Calpain-3 in Sarcoplasmic Reticulum in Skeletal Muscles

(2011) Koichi Ojima et al.   JOURNAL OF MOLECULAR BIOLOGY

Calpain chronicle—an enzyme family under multidisciplinary characterization

(2011) Hiroyuki SORIMACHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction

(2010) Yohei Osako et al.   FEBS Journal

A Plasma Membrane Wound Proteome

(2010) Ronald L. Mellgren   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle-specific Calpain Is an Intracellular Na+-dependent Protease

(2010) Yasuko Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

(2010) Koichi Ojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Calpain-10 is a component of the obesity-related quantitative trait locus Adip1

(2010) J. M. Cheverud et al.   JOURNAL OF LIPID RESEARCH

Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation

(2010) Aki Kashiwagi et al.   MOLECULAR AND CELLULAR BIOLOGY

A Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals

(2010) Daniel J. Macqueen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Calpain 8/nCL-2 and Calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense

(2010) Shoji Hata et al.   PLoS Genetics

Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice

(2009) Shinji Nakada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium-dependent plasma membrane repair requires m- or μ-calpain, but not calpain-3, the proteasome, or caspases

(2009) Ronald L. Mellgren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of calpain-9 and PKC-δ in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells

(2009) Charng-Jui Chen et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

(2009) Masami Yamada et al.   NATURE MEDICINE

Arrested growth of Trypanosoma cruzi by the calpain inhibitor MDL28170 and detection of calpain homologues in epimastigote forms

(2009) L. S. SANGENITO et al.   PARASITOLOGY

Cell Morphogenesis of Trypanosoma brucei Requires the Paralogous, Differentially Expressed Calpain-related Proteins CAP5.5 and CAP5.5V

(2009) Sofia Olego-Fernandez et al.   PROTIST

Physiological Involvement in pH Signaling of Vps24-mediated Recruitment ofAspergillusPalB Cysteine Protease to ESCRT-III

(2008) Olga Rodríguez-Galán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

(2008) Rachel A. Hanna et al.   NATURE

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains

(2008) Tudor Moldoveanu et al.   NATURE