Article
Chemistry, Multidisciplinary
Polina A. Demina, Anatolii A. Abalymov, Denis V. Voronin, Alexandr V. Sadovnikov, Maria V. Lomova
Summary: The study introduces anticancer hybrid mineral highly-magnetic protein-tannin vehicles as tunable and controllable triggers for drug delivery systems. Results show effective encapsulation and storage of drugs in the vehicles, with a higher cytostatic effect on breast cancer cells compared to healthy cells. The core-shell magnetic anticancer structures show potential for long-term preservation of antitumor drugs.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Jaeho Shin, Baksun Kim, Tyson W. Lager, Franklin Mejia, Ian Guldner, Clay Conner, Siyuan Zhang, Athanasia D. Panopoulos, Basar Bilgicer
Summary: This study describes the rational engineering of liposomal nanoparticles loaded with a doxorubicin prodrug to selectively target metastatic breast cancer cells in vivo. Glucose-regulated protein 78 (GRP78), which is typically localized in the endoplasmic reticulum, has been identified as a promising therapeutic target in certain cancers. The researchers optimized a nanoparticle formulation with a GRP78-binding peptide to selectively target an aggressive subpopulation of stem-like breast cancer cells expressing surface GRP78.
Article
Materials Science, Biomaterials
Jieying Zhang, Fang Li, Lili Su, Qian Hu, Jianfeng Li, Xingjun Zhu
Summary: Tumor vascular disruption has become a promising strategy for cancer therapy in recent decades. Nanocomposites loaded with therapeutic materials and drugs are expected to improve the accuracy of anti-vascular therapy and minimize side effects. However, how to prolong blood circulation of therapeutic nanocomposites for enhanced accumulation in tumor vasculature and how to monitor the initial efficacy of anti-vascular therapy for early evaluation of prognosis remain unsolved.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Zuha Imtiyaz, Jiaxi He, Qixin Leng, Atul K. Agrawal, A. James Mixson
Summary: Researchers are exploring various nanoparticle methods to deliver chemotherapeutic agents to tumors with higher accumulation. pH-dependent histidine-based nanoparticles show promising potential for treatment, but challenges remain in clinical trials.
Article
Chemistry, Medicinal
Quanling Guo, Lu Zhang, Mengmeng He, Xiaohua Jiang, Jingrui Tian, Qiurong Li, Zhiwei Liu, Longgang Wang, Haotian Sun
Summary: A method utilizing amphipathic and natural antibacterial peptide daptomycin to stabilize doxorubicin and form zwitterionic nanodrug showed promising targeting and anti-tumor effects in experiments, with higher cytotoxicity and tumor inhibition rate than free doxorubicin. The biocompatible daptomycin-based drug delivery system selectively accumulated at tumor sites in vivo through EPR effect, reducing toxicity and achieving excellent tumor inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Siyuan Chen, Furong Qin, Manni Wang, Yuquan Wei, Zhiyong Qian, Xiawei Wei
Summary: The tumor microenvironment is crucial for tumorigenesis, metastasis, and drug resistance. Tumor-associated macrophages (TAMs) play a key role in creating a favorable environment for cancer cells, and nanoparticle-based drug delivery systems offer new approaches for targeting TAMs in cancer therapy. Strategies targeting TAMs with nanoparticles include blocking recruitment, promoting transformation, and diminishing existing TAMs to improve cancer treatment efficiency.
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Zun Yang, Haijiao Li, Wenrui Zhang, Mingzu Zhang, Jinlin He, Zepeng Yu, Xingwei Sun, Peihong Ni
Summary: Tumor-associated macrophages (TAMs)-based immunotherapy is a promising strategy due to their promoting effect on tumor growth, invasion, and metastasis. In this study, CD163 monoclonal antibody modified doxorubicin-polymer prodrug nanoparticles (mAb-CD163-PDNPs) were prepared for active targeting to TAMs. The mAb-CD163-PDNPs could respond to the acidic environment in tumor cells and release drugs, showing a strong inhibitory effect on TAMs and tumor cells. The in vivo test also demonstrated a good therapeutic effect with a tumor inhibition rate of 81%.
Article
Engineering, Biomedical
Xiying Fan, Xinying Peng, Tingting Wang, Yi Gu, Guochuan Sun, Qinghui Shou, Haipeng Song, Rui Nian, Wenshuai Liu
Summary: This study aimed to establish a simple and feasible method to obtain silk fibroin nanoparticles (SFNPs) with uniform particle size and then modify them with nanobody (Nb) 11C12 for targeted delivery to colorectal cancer (CRC) cells. The SFNPs were formed by self-assembly of regenerated silk fibroin (SF), and the release of the anticancer drug doxorubicin hydrochloride (DOX) from the SFNPs could be accelerated in a weakly acidic environment. The nanoparticle modification with Nb 11C12 enhanced the uptake by CRC cells and exhibited good safety and biocompatibility.
BIOMEDICAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Marta Sevieri, Mattia Pinori, Arianna Chesi, Arianna Bonizzi, Leopoldo Sitia, Marta Truffi, Carlo Morasso, Fabio Corsi, Serena Mazzucchelli
Summary: Due to its unique architecture and specific targeting ability, ferritin is an attractive biomaterial for drug delivery. Chemotherapeutics have been loaded into ferritin nanocages and their antitumor efficacy has been explored. However, there are challenges for the clinical translation of ferritin as drug carriers. This review summarizes the efforts to maximize the features of ferritin and improve its stability and in vivo circulation.
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Medicine, Research & Experimental
Wenpan Li, Nicholas Little, Jonghan Park, Cole Alexander Foster, Jiawei Chen, Jianqin Lu
Summary: Nanoparticle drug delivery systems have improved antitumor efficacy, but achieving satisfactory distribution and penetration inside solid tumors, especially in stromal fibrous tumors, remains challenging. Tumor-associated fibroblasts reduce the drug delivery efficiency of nanoparticles, making them attractive targets for enhancing tumor delivery efficiency and efficacy of anticancer agents. Opportunities to summarize the underlying mechanisms of TAFs on obstructing nanoparticle-mediated drug delivery into tumors and discuss nanotherapeutic approaches for effectively targeting TAFs have been extensively explored.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri, Giulia Anderluzzi, Barbara Colombo, Alessandro Gori, Anna Mondino, Flavio Curnis
Summary: Gold nanospheres tagged with isoDGR peptides can efficiently deliver pro-inflammatory cytokines to tumor vasculature. Bifunctional or trifunctional nanoparticles loaded with TNF and/or IL12, along with isoDGR peptides, show anti-cancer effects in a mouse model of fibrosarcoma by delaying tumor growth and enhancing doxorubicin efficacy without increasing toxicity. Mechanistic studies suggest that these nanoparticles can improve doxorubicin penetration in tumors and cause vascular damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Nazim Muhammad, He Zhao, Wenjing Song, Mingyang Gu, Qian Li, Yujia Liu, Cheng Li, Jihui Wang, Honglei Zhan
Summary: The study demonstrated the potential advantages of NR1/AgNP-decorated PTX nanocrystals in enhancing chemotherapy, improving anti-cancer activity, and inhibiting cancer cell migration, while achieving a balance between good selectivity and biocompatibility.
Article
Nanoscience & Nanotechnology
Jin-Hu Dong, Yao Ma, Rong Li, Wen-Tao Zhang, Meng-Qian Zhang, Fan-Ning Meng, Kai Ding, Hai-Tao Jiang, Yong-Kuan Gong
Summary: The research team developed a smart drug delivery system based on mesoporous silica nanoparticles, allowing for controlled release and targeted delivery to tumor cells with high selectivity and killing efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Food Science & Technology
I. M. Krishnakumar, Abhilash Maliakel, G. Gopakumar, Dinesh Kumar, Balu Maliakel, Ramadasan Kuttan
JOURNAL OF FUNCTIONAL FOODS
(2015)
Article
Biochemistry & Molecular Biology
N. M. Johannah, R. M. Renny, G. Gopakumar, Balu Maliakel, D. Sureshkumar, I. M. Krishnakumar
Article
Biochemistry & Molecular Biology
Abin Issac, G. Gopakumar, Ramadasan Kuttan, Balu Maliakel, I. M. Krishnakumar
Article
Pharmacology & Pharmacy
Subash Pandaran Sudheeran, Della Jacob, Johannah Natinga Mulakal, Gopakumar Gopinathan Nair, Abhilash Maliakel, Balu Maliakel, Ramadasan Kuttan, I. M. Krishnakumar
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2016)
Article
Chemistry, Medicinal
S. Shamshad Begum, H. K. Jayalakshmi, H. G. Vidyavathi, G. Gopakumar, Issac Abin, Maliakel Balu, K. Geetha, S. V. Suresha, M. Vasundhara, I. M. Krishnakumar
PHYTOTHERAPY RESEARCH
(2016)
Article
Food Science & Technology
P. S. Rajeev, N. M. Johannah, G. Gopakumar, Balu Maliakel, I. M. Krishnakumar
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2017)
Article
Biotechnology & Applied Microbiology
Gopakumar Gopinathan Nair, Cherupally Krishnan Krishnan Nair
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Biochemistry & Molecular Biology
Changliang Chen, Prachi Gupta, Deepak Parashar, Gopakumar G. Nair, Jasmine George, Anjali Geethadevi, Wei Wang, Shirng-Wern Tsaih, William Bradley, Ramani Ramchandran, Janet S. Rader, Pradeep Chaluvally-Raghavan, Sunila Pradeep
Article
Oncology
Deepak Parashar, Bindu Nair, Anjali Geethadevi, Jasmine George, Ajay Nair, Shirng-Wern Tsaih, Ishaque P. Kadamberi, Gopa Kumar Gopinadhan Nair, Yiling Lu, Ramani Ramchandran, Denise S. Uyar, Janet S. Rader, Prahlad T. Ram, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Article
Medicine, General & Internal
Gopa Kumar Gopinadhan Nair, Dimitrios Pollalis, Jonathan D. Wren, Constantin Georgescu, Virginie Sjoelund, Sun Young Lee
Summary: This study characterized vitreous humor (VH) exosomes and explored their role in the development of proliferative vitreoretinopathy (PVR) using mass spectrometry-based proteome profiling. The results suggest that exosomes may play a key role in mediating tissue remodeling along with a complex set of pathways involved in PVR development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Dimitrios Pollalis, Dongin Kim, Gopa Kumar Gopinadhan Nair, Changsun Kang, Arjun Nanda, Sun Young Lee
Summary: This study evaluates the transretinal penetration of intravitreally injected retinal multicell-derived exosomes and demonstrates the potential of ASL-modified exosomes in actively targeting choroidal neovascularization (CNV).
Meeting Abstract
Ophthalmology
Gopa Kumar Gopinadhan Nair, James Randolph Sanders Hocker, Dimitrios Pollalis, Sun Young Lee
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Oncology
Deepak Parashar, Anjali Geethadevi, Jasmine George, Gopakumar Gopinathan Nair, Changliang Chen, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Article
Toxicology
Liju Vijayasteltar, Gopakumar Gopinathan Nair, Balu Maliakel, Ramadasan Kuttan, I. M. Krishnakumar
TOXICOLOGY REPORTS
(2016)