Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions

Role of Insulin Signaling in Maintaining Energy Homeostasis

(2013) Morali Sharma et al.   Endocrine Practice

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice

(2012) Marco Aurélio Ramirez Vinolo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13

(2012) Chad E. Grueter et al.   CELL

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors

(2012) Ya Tuo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

G-protein-coupled receptors as fat sensors

(2012) Marco A.R. Vinolo et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

(2012) H. Li et al.   DIABETES

Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice

(2012) I. Mothe-Satney et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat Model

(2012) Feixiang Wu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Advances in Muscle Physiology and Pathophysiology 2011

(2012) Aikaterini Kontrogianni-Konstantopoulos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

MicroRNAs and Induced Pluripotent Stem Cells for Human Disease Mouse Modeling

(2012) Chingiz Underbayev et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis

(2012) Mariko Murata et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes

(2012) N. H. Foley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

(2012) Amanda R Martins et al.   Lipids in Health and Disease

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin

(2012) Maarten Hulsmans et al.   PLoS One

Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance

(2012) Ilias Stagakis et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria

(2011) Dawn K. Coletta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of MicroRNAs in Cholesterol Efflux and Hepatic Lipid Metabolism

(2011) Kathryn J. Moore et al.   Annual Review of Nutrition

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

(2011) R. Winkler et al.   DIABETES

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

(2011) Olivia Lenoir et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis

(2011) Maarten Hulsmans et al.   FASEB JOURNAL

IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes

(2011) Chenbo Ji et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Transforming Growth Factor-β-induced, Hyaluronan-dependent, T Cell Adhesion to Orbital Fibroblasts

(2011) Naxin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor-4 (TLR4) Down-regulates MicroRNA-107, Increasing Macrophage Adhesion via Cyclin-dependent Kinase 6

(2011) Elizabeth J. Hennessy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

(2011) Ramkumar Rajendran et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Design and Characterization of a Potent and Selective Dual ATP- and Substrate-Competitive Subnanomolar Bidentate c-Jun N-Terminal Kinase (JNK) Inhibitor

(2011) John L. Stebbins et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2011) Eli Lewis et al.   MOLECULAR MEDICINE

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(2011) Thomas Wascher et al.   MOLECULAR MEDICINE

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(2011) Dan Christensen et al.   MOLECULAR MEDICINE

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue

(2011) J. Kurokawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance

(2011) Federico Mayor et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-α therapy

(2010) Miguel A. Gonzalez-Gay et al.   Annals of the New York Academy of Sciences

Vascular Smooth Muscle Cell Peroxisome Proliferator–Activated Receptor-γ Mediates Pioglitazone-Reduced Vascular Lesion Formation

(2010) Milton Hamblin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Palmitate and insulin synergistically induce IL-6 expression in human monocytes

(2010) Robert C Bunn et al.   Cardiovascular Diabetology

PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice

(2010) Anna Foryst-Ludwig et al.   Cardiovascular Diabetology

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression

(2010) Ira Tabas et al.   CIRCULATION RESEARCH

Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice

(2010) P. J. White et al.   DIABETES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

(2010) B. M. Herrera et al.   DIABETOLOGIA

Toll-Like Receptor Ligands Cause Proinflammatory and Prodiabetic Activation of Adipocytes via Phosphorylation of Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase But Not Interferon Regulatory Factor-3

(2010) Andrea Kopp et al.   ENDOCRINOLOGY

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Postprandial lipaemia, oxidative stress and endothelial function: a review

(2010) J. P. Wallace et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Reconstruction of Protein-Protein Interaction Network of Insulin Signaling inHomo Sapiens

(2010) Saliha Durmuş Tekir et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Advances in Muscle Physiology and Pathophysiology

(2010) Aikaterini Kontrogianni-Konstantopoulos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation

(2010) M. Di Carlo et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Skeletal Muscle Insulin Resistance in Endocrine Disease

(2010) Melpomeni Peppa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice

(2010) Lin Zhang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity

(2010) R. Horrillo et al.   JOURNAL OF IMMUNOLOGY

β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

(2010) Xiaotao Feng et al.   MOLECULAR BIOLOGY REPORTS

miRNAs as biomarkers in colorectal cancer diagnosis and prognosis

(2010) Jingfang Ju   Bioanalysis

Kupffer cell activation is a causal factor for hepatic insulin resistance

(2009) Nicolas Lanthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes

(2009) Yang-liang Ye et al.   BIOORGANIC & MEDICINAL CHEMISTRY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

(2009) H. Xie et al.   DIABETES

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis

(2009) Sandra J. Saouaf et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of microRNAs in the regulation of drug metabolism and disposition

(2009) Ai-Ming Yu   Expert Opinion on Drug Metabolism & Toxicology

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

(2009) Markus Feuerer et al.   IMMUNITY

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Insulin signaling regulating genes: effect on T2DM and cardiovascular risk

(2009) Sabrina Prudente et al.   Nature Reviews Endocrinology

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

(2009) Nava Bashan et al.   PHYSIOLOGICAL REVIEWS

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase

(2008) Helen Cho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

(2008) Liliana Håversen et al.   ATHEROSCLEROSIS

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

(2008) Viviane Zorzanelli Rocha et al.   CIRCULATION RESEARCH

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Adaptation and Maladaptation of the Heart in Obesity

(2008) Romain Harmancey et al.   HYPERTENSION

Updating the effects of fatty acids on skeletal muscle

(2008) Leonardo R. Silveira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

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(2008) Herbert Tilg et al.   MOLECULAR MEDICINE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of glucose-regulated miRNAs from pancreatic   cells reveals a role for miR-30d in insulin transcription

(2008) X. Tang et al.   RNA