Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammed Yusuf Zanna, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Suri Arshad, Abdul Razak Mariatulqabtiah, Saulol Hamid Nur-Fazila, Md Isa Nur Mahiza
Summary: Dendritic cells are crucial antigen-presenting cells in the immune system, playing a significant role in activating T cells and maintaining immune balance. Their distribution and dynamic perspectives in various animal species, as well as their roles in diseases, have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chengcheng Liu, Wenwen Qi, Zhenxiao Teng, Runtong Xu, Yue Xi, Yiming Qin, Fenglei Xu, Lei Shi, Miaoqing Zhao, Ming Xia
Summary: This study suggests that NGR-PM-SHI could be a novel strategy for targeted treatment of allergic rhinitis through the NF-kappa B pathway by targeting PARP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Nathifa A. Moyo, Dave Westcott, Rachel Simmonds, Falko Steinbach
Summary: This study investigates the interaction between EAV and host immune cells, specifically dendritic cells (DC), using an optimized eqMoDC system. The results show that EAV is able to replicate in monocytes and mature MoDC, and has an effect on cell morphology, phenotype, and function. EAV evades host anti-viral immunity through inhibition of antigen presentation early after infection and by killing infected DC during replication.
Article
Immunology
Sara Sadat Aghamiri, Bhanwar Lal Puniya, Rada Amin, Tomas Helikar
Summary: Dendritic cells (DCs) are professional antigen-presenting cells that play a critical role in shaping immunity. Researchers have developed a logical and predictive model of DC function, integrating the heterogeneity of DCs population, APC function, and cell-cell interaction, to study cell dynamics and disease environments, providing a platform for vaccine design, drug discovery, and immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Wenhui Hu, Yun Wang, Jin Chen, Peng Yu, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Shi Zhou, Jinhua Long, Zhu Zeng
Summary: The performance of implanted biomaterials is influenced by their interaction with the host immune system. Study found that fibrin plays a key role in regulating the immune behavior of dendritic cells (DCs).
MATERIALS TODAY BIO
(2022)
Article
Biology
Alessio Alesci, Gioele Capillo, Angelo Fumia, Emmanuele Messina, Marco Albano, Marialuisa Aragona, Patrizia Lo Cascio, Nunziacarla Spano, Simona Pergolizzi, Eugenia Rita Lauriano
Summary: This study aimed to characterize intestinal dendritic cells (DCs) from myxines to teleosts using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II. The findings reveal the presence of DCs and DC-like cells phylogenetically from myxines to teleosts, providing new insights into the evolution of the immune system and the role of sentinel cells in body defense.
Article
Biochemistry & Molecular Biology
Bernardo Bonilauri, Marlon D. M. Santos, Amanda Caroline Camillo-Andrade, Saloe Bispo, Fabio C. S. Nogueira, Paulo C. Carvalho, Nilson I. T. Zanchin, Juliana de S. da G. Fischer
Summary: The delay in blood-processing time directly impacts the proteomic profile of human PBMC, possibly through granulocyte contamination and activation.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Review
Immunology
Paulo Arantes Laginha, Fernanda Vieira Lins Arcoverde, Luiza Gama Coelho Riccio, Marina Paula Andres, Mauricio Simoes Abrao
Summary: Research suggests that dendritic cells play a critical role in the development and progression of endometriosis, being susceptible to pro-endometriotic changes that inhibit maturation and induce a macrophage phenotype. Endometriosis growth and vascularization rely on the presence of endogenous dendritic cells, which promote endothelial cell migration and angiogenesis. Immature dendritic cells actively support angiogenesis and endometriosis progression, changing their immunologic role from antigen presentation to angiogenesis support.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Mark A. Travis, Chiara Romagnani
Summary: Active control of the immune system is necessary to prevent inflammatory bowel disease. Cell populations that promote the generation of immunosuppressive regulatory T cells in the gut have been identified.
Article
Immunology
David M. Koelle, Lichun Dong, Lichen Jing, Kerry J. Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M. Posavad
Summary: HSV-2-specific T-RM cells are abundant in the female reproductive tract between episodes of recurrent genital herpes, provide protection, and maintain the ability to expand.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chae Won Kim, Kyun-Do Kim, Heung Kyu Lee
Summary: Dendritic cells play a crucial role in initiating antitumor immune responses through antigen presentation. Different subsets of DCs have distinct roles in the tumor microenvironment, and regulating DC functionality holds promise for improving cancer therapies.
Review
Oncology
Jiaxin Li, Jun Zhou, Huanhuan Huang, Jiahuan Jiang, Ting Zhang, Chao Ni
Summary: This article summarizes the important role of mature dendritic cells (mregDCs) in regulating the immune response and their potential impact on tumor immunotherapy. Recent research has shown that these regulatory cells are associated with a positive response to immunotherapy and a favorable prognosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Thomas Koehnke, Xilong Liu, Sascha Haubner, Veit Buecklein, Gerulf Haenel, Christina Krupka, Victor Solis-Mezarino, Franz Herzog, Marion Subklewe
Summary: This study optimized the Cell Surface Capture protocol to directly investigate primary AML patient samples and applied it to generate the AML surfaceome. The curated AML surfaceome was further enriched using mutational burden data from hematologic cancers, resulting in a set of potential target antigens. Validation in a separate cohort of AML patient samples confirmed the most promising novel candidate markers, including CD148, ITGA4, and Integrin beta-7.
BIOMARKER RESEARCH
(2022)
Article
Allergy
Cristina Benito-Villalvilla, Andres de la Rocha-Munoz, Jacobo Lopez-Abente, Alexander Eggel, Ivan Bottoli, Thomas Severin, Maximilian Woisetschlager, Oscar Palomares
Summary: Ligelizumab has a stronger capacity than omalizumab to regulate functional properties of plasmacytoid dendritic cells (pDCs), including the blocking of IgE binding to Fc epsilon RI and the restoration of IFN-alpha production and Treg generation. These findings provide important clinical implications for anti-IgE treatments in different IgE-mediated diseases.
Article
Pharmacology & Pharmacy
Dongling Liu, Xiang Zeng, Xiao Li, Chaochu Cui, Ruanling Hou, Zhikun Guo, Jawahar L. Mehta, Xianwei Wang
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Chaochu Cui, Jianbo Yang, Xiao Li, Dongling Liu, Liwu Fu, Xianwei Wang
Article
Oncology
Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhang
MOLECULAR MEDICINE REPORTS
(2020)
Article
Neurosciences
Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhang
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Peng Chen, Fen Yang, Wenya Wang, Xiao Li, Dongling Liu, Yongxi Zhang, Guotian Yin, Fenghua Lv, Zhikun Guo, Jawahar L. Mehta, Xianwei Wang
Summary: The study found that liraglutide can reduce blood pressure and blood sugar in hypertensive mice, inhibit cardiac fibrosis, and decrease AT1R expression and ROS generation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Review
Cardiac & Cardiovascular Systems
Weijia Cheng, Xiao Li, Dongling Liu, Chaochu Cui, Xianwei Wang
Summary: Endothelial-to-mesenchymal transition (EndMT) is a complex biological process where endothelial cells transition into mesenchymal cells, and it has been found to be crucial in fibrotic cardiovascular diseases, potentially offering new therapeutic targets.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Cell Biology
Xiangqin Tian, Changye Sun, Xianwei Wang, Ketao Ma, Yuqiao Chang, Zhikun Guo, Junqiang Si
Article
Cell Biology
Rajshekhar A. Kore, Xianwei Wang, Zufeng Ding, Robert J. Griffin, Alan J. Tackett, Jawahar L. Mehta
Summary: MSC exosomes show significant effects in limiting and reversing cardiac injury, particularly in the peri-infarct areas. By suppressing inflammation and pro-apoptotic processes, especially in the peri-infarct areas, they exert cardioprotective effects leading to preservation of cardiac function.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Jinghang Zhang, Lihong Pei, Dan Zang, Yun Xue, Xiaohui Wang, Yiyang Chen, Jinsong Li, Jian Yu, Qingzu Gao, Wenyu Di, Chaochu Cui, Wei Su, Xianwei Wang
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Letter
Cardiac & Cardiovascular Systems
Xiao Li, Anna N. Brickell, Xianwei Wang, Sichang Zhou, Zufeng Ding
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dongling Liu, Xiang Zeng, Zufeng Ding, Fenghua Lv, Jawahar L. Mehta, Xianwei Wang
Summary: COVID-19 infection has a high mortality rate in patients with preexisting cardiovascular diseases, and those with cardiovascular comorbidities have a higher risk of death. Drugs used to treat COVID-19 can have adverse effects on the heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao Li, Xihe Tang, Bo Liu, Jinghang Zhang, Yongxi Zhang, Hefan Lv, Dongling Liu, Jawahar L. Mehta, Xianwei Wang
Summary: LOX-1 deletion limits cardiac fibrosis and ROS production in aged mice, with a more pronounced effect observed in aged mice with hypertension induced by Ang II infusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell Biology
Na Lu, Weijia Cheng, Dongling Liu, Gang Liu, Can Cui, Chaoli Feng, Xianwei Wang
Summary: NLRP3 inflammasome is a crucial part of the body's immune system, and its overactivation has been linked to inflammatory responses and atherosclerosis. Therefore, finding specific inhibitors for NLRP3 inflammasome has become a potential target for clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Weijia Cheng, Can Cui, Gang Liu, Chenji Ye, Fang Shao, Ashim K. Bagchi, Jawahar L. Mehta, Xianwei Wang
Summary: Cardiovascular diseases (CVDs) are the leading cause of death globally, mainly associated with atherosclerosis. The transcription factor NF-kappa B is linked to target genes involved in atherosclerosis. Modulating NF-kappa B signaling pathways may be a potential approach in the treatment of atherosclerosis and related CVDs.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Xianwei Wang, Xiao Li, Shijie Liu, Anna N. Brickell, Jinghang Zhang, Zekun Wu, Sichang Zhou, Zufeng Ding
BASIC RESEARCH IN CARDIOLOGY
(2020)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
