Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds

Antiviral resistance due to deletion in the neuraminidase gene and defective interfering-like viral polymerase basic 2 RNA of influenza A virus subtype H3N2

(2018) Ramona Trebbien et al.   JOURNAL OF CLINICAL VIROLOGY

An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness

(2018) Jin Jung Kwon et al.   JOURNAL OF GENERAL VIROLOGY

Immunization and treatment updates: 2016-2017 influenza season

(2017) Annabelle de St. Maurice et al.   PEDIATRIC TRANSPLANTATION

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

(2017) Nicholas C. Wu et al.   PLoS Pathogens

Update: Increase in Human Infections with Novel Asian Lineage Avian Influenza A(H7N9) Viruses During the Fifth Epidemic — China, October 1, 2016–August 7, 2017

(2017) James C. Kile et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe

(2017) A Lackenby et al.   Eurosurveillance

Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I

(2015) Alexander S. Jureka et al.   STRUCTURE

Functions of the influenza A virus NS1 protein in antiviral defense

(2015) Robert M Krug   Current Opinion in Virology

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence

(2014) J. Ayllon et al.   JOURNAL OF VIROLOGY

Identification of Adaptive Mutations in the Influenza A Virus Non-Structural 1 Gene That Increase Cytoplasmic Localization and Differentially Regulate Host Gene Expression

(2014) Nicole Forbes et al.   PLoS One

19F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus

(2014) James M. Aramini et al.   STRUCTURE

The influenza virus NS1 protein as a therapeutic target

(2013) Daniel A. Engel   ANTIVIRAL RESEARCH

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30

(2013) Samar K Dankar et al.   Virology Journal

Conservation of a crystallographic interface suggests a role for β-sheet augmentation in influenza virus NS1 multifunctionality

(2011) Philip S. Kerry et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

(2011) Joseph J. Jablonski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus

(2011) James M. Aramini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is Increased by Correcting a Defect in Their NS1 Proteins

(2011) A. Spesock et al.   JOURNAL OF VIROLOGY

A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain

(2011) Philip S. Kerry et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner

(2010) M. P. Walkiewicz et al.   JOURNAL OF GENERAL VIROLOGY

Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein

(2010) B. G. Hale et al.   JOURNAL OF VIROLOGY

X-ray structures of NS1 effector domain mutants

(2009) Shuangluo Xia et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus

(2009) Y. Yang et al.   SCIENCE

The origin and global emergence of adamantane resistant A/H3N2 influenza viruses

(2009) Martha I. Nelson et al.   VIROLOGY

Structure of NS1A effector domain from the influenza A/Udorn/72 virus

(2008) Shuangluo Xia et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008

(2008) T. G. Sheu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current and future antiviral therapy of severe seasonal and avian influenza

(2008) John Beigel et al.   ANTIVIRAL RESEARCH

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Novel Influenza Virus NS1 Antagonists Block Replication and Restore Innate Immune Function

(2008) D. Basu et al.   JOURNAL OF VIROLOGY

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an avian influenza A virus NS1 protein effector domain

(2008) Benjamin G. Hale et al.   VIROLOGY