Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

(2013) Di Liu et al.   LANCET

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly Pathogenic H5N1 Influenza A Virus Strains Provoke Heterogeneous IFN-α/β Responses That Distinctively Affect Viral Propagation in Human Cells

(2013) Markus Matthaei et al.   PLoS One

Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

(2012) Nicole E. Forbes et al.   PLoS One

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Methionine-101 from one strain of H5N1 NS1 protein determines its IFN-antagonizing ability and subcellular distribution pattern

(2012) Jin Meng et al.   Science China-Life Sciences

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines

(2011) Fransiskus X. Ivan et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Enhanced Growth of Influenza Vaccine Seed Viruses in Vero Cells Mediated by Broadening the Optimal pH Range for Virus Membrane Fusion

(2011) S. Murakami et al.   JOURNAL OF VIROLOGY

The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is Increased by Correcting a Defect in Their NS1 Proteins

(2011) A. Spesock et al.   JOURNAL OF VIROLOGY

Deciphering interactions used by the influenza virus NS1 protein to silence the host antiviral sensor protein RIG-I using a bacterial reverse two-hybrid system

(2011) Elena Miranda et al.   Molecular BioSystems

Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

(2011) Jihui Ping et al.   PLoS One

Serial Histopathological Examination of the Lungs of Mice Infected with Influenza A Virus PR8 Strain

(2011) Masaya Fukushi et al.   PLoS One

Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility

(2011) Sanjay Mukherjee et al.   Virology Journal

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

(2011) Samar K Dankar et al.   Virology Journal

Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

(2011) Sergey Kryazhimskiy et al.   PLoS Genetics

Simple genomes, complex interactions: Epistasis in RNA virus

(2010) Santiago F. Elena et al.   CHAOS

New regulatory mechanisms for the intracellular localization and trafficking of influenza A virus NS1 protein revealed by comparative analysis of A/PR/8/34 and A/Sydney/5/97

(2010) H. Han et al.   JOURNAL OF GENERAL VIROLOGY

Glycine 184 in Nonstructural Protein NS1 Determines the Virulence of Influenza A Virus Strain PR8 without Affecting the Host Interferon Response

(2010) S. Steidle et al.   JOURNAL OF VIROLOGY

PB2 and Hemagglutinin Mutations Are Major Determinants of Host Range and Virulence in Mouse-Adapted Influenza A Virus

(2010) Jihui Ping et al.   JOURNAL OF VIROLOGY

Phylogenetic and Molecular Characterization of H9N2 Influenza Isolates from Chickens in Northern China from 2007–2009

(2010) Jianmin Bi et al.   PLoS One

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

(2010) Danlin Jia et al.   PLoS One

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

The hemagglutinin protein of influenza A/Vietnam/1203/2004 (H5N1) contributes to hyperinduction of proinflammatory cytokines in human epithelial cells

(2010) Xing Cheng et al.   VIROLOGY

Acute respiratory distress syndrome induced by H9N2 virus in mice

(2009) Guangcun Deng et al.   ARCHIVES OF VIROLOGY

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Nuclear localization signals and human disease

(2009) Laura M. McLane et al.   IUBMB LIFE

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Simplified recombinational approach for influenza A virus reverse genetics

(2008) Shuai Wang et al.   JOURNAL OF VIROLOGICAL METHODS

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Export Signal Consensus Sequences Defined Using a Localization-Based Yeast Selection System

(2008) Shunichi Kosugi et al.   TRAFFIC