trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

(2014) Marta Carroni et al.   eLife

Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor

(2014) Cathleen Zeymer et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

(2013) Benjamin M. Stinson et al.   CELL

The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride

(2013) Cathleen Zeymer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computer Simulation of Assembly and Co-operativity of Hexameric AAA ATPases

(2013) Doan Tuong-Van Le et al.   PLoS One

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

Aggregate reactivation mediated by the Hsp100 chaperones

(2012) Michal Zolkiewski et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Mapping the road to recovery: The ClpB/Hsp104 molecular chaperone

(2012) Skye Hodson et al.   JOURNAL OF STRUCTURAL BIOLOGY

Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine

(2012) Amadeo B. Biter et al.   JOURNAL OF STRUCTURAL BIOLOGY

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A tightly regulated molecular toggle controls AAA+ disaggregase

(2012) Yuki Oguchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Roles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilus

(2011) Takashi Yamasaki et al.   FEBS Journal

Regulatory Circuits of the AAA+ Disaggregase Hsp104

(2011) Titus M. Franzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Communication between the Nucleotide Binding Domains of Caseinolytic Peptidase B

(2011) José Ángel Fernández-Higuero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of the hexameric MecA–ClpC molecular machine

(2011) Feng Wang et al.   NATURE

Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation

(2011) M. Miot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling of Oligomerization and Nucleotide Binding in the AAA+ Chaperone ClpB

(2010) Nicolas D. Werbeck et al.   BIOCHEMISTRY

The M-Domain Controls Hsp104 Protein Remodeling Activity in an Hsp70/Hsp40-Dependent Manner

(2010) Bernhard Sielaff et al.   JOURNAL OF MOLECULAR BIOLOGY

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation

(2010) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide Binding and Allosteric Modulation of the Second AAA+ Domain of ClpB Probed by Transient Kinetic Studies

(2009) Nicolas D. Werbeck et al.   BIOCHEMISTRY

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine

(2009) Steven E. Glynn et al.   CELL

Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB

(2008) Nicolas D. Werbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES