Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal Degradation

Cyclopamine: From Cyclops Lambs to Cancer Treatment

(2014) Stephen T. Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

(2014) Ilker Karaca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-  Peptide

(2013) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

(2013) V. K. Burg et al.   JOURNAL OF NEUROSCIENCE

Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65

(2013) Yi Xiang et al.   Nature Communications

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

(2011) Gael Barthet et al.   FASEB JOURNAL

Cysteine 27 Variant of the  -Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking

(2011) T. Sarajarvi et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects

(2011) Ranjita Chakraborty et al.   PLoS One

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase

(2009) Lie-Feng Wang et al.   MOLECULES

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

New developments in medulloblastoma treatment: the potential of a cyclopamine–lovastatin combination

(2008) Eli E Bar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex

(2008) M. Dahlhaus et al.   JOURNAL OF NEUROSCIENCE

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY