Editorial Material
Cell Biology
Yalan Wang, Hongyan Wang, Chenji Wang
Summary: In neuronal ceroid lipofuscinoses (NCLs), mutations in the KCTD7 gene lead to lysosomal dysfunction and macroautophagic/autophagic defects, resulting in the accumulation of lysosomal storage deposits. Our study demonstrates that KCTD7 is a key player in maintaining lysosomal and autophagic homeostasis, and it is biochemically linked with CLN5, another NCL causative gene, in a common neurodegenerative pathway.
Review
Oncology
Destiny F. Schultz, Daniel D. Billadeau, Seetharama D. Jois
Summary: The development of tumors is associated with spontaneous dimerization and dysregulation of EGFR signaling. Attenuation of EGFR signaling is necessary for normal cell growth, and resistance to current treatment strategies can occur due to alterations in EGFR trafficking. Targeting EGFR trafficking may aid in the treatment of cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Lauren V. Albrecht, Nydia Tejeda-Munoz, Edward M. De Robertis
Summary: Recent investigations have revealed that Wnt signaling can regulate various cell physiological effects, promoting cell growth by mechanisms such as Wnt receptor endocytosis, Wnt-induced protein stabilization, and metabolic changes. A key element is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular bodies and lysosomes, which affects the phosphorylation motifs of GSK3 and protein degradation. These effects are independent of new protein synthesis and contribute to cell growth.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37
(2021)
Article
Biochemistry & Molecular Biology
Jaeeun Jung, Jiseok Baek, Kun Tae, Donghyuk Shin, Seungsu Han, Wonjin Yang, Wookyung Yu, Su Myung Jung, Seok Hee Park, Cheol Yong Choi, Sangho Lee
Summary: The study reveals the molecular mechanisms underlying the regulation of Rab7 by site-specific monoubiquitination, where ubiquitination on K191 and K194 plays a crucial role in membrane localization and interaction with SARS-CoV-2. This highlights the common regulatory effects of Rab proteins through site-specific monoubiquitination while emphasizing the specific roles of different ubiquitination sites in each Rab protein.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Yuchen Feng, Aileen R. Ariosa, Ying Yang, Zehan Hu, Joern Dengjel, Daniel J. Klionsky
Summary: Macroautophagy/autophagy is a crucial molecular process for maintaining cellular homeostasis, recycling cytoplasmic materials, and responding to stress conditions. The posttranslational modification of Atg9, including ubiquitination and proteasome-dependent degradation, regulates the level of autophagy in cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Chung-Ling Lu, Jinoh Kim
Summary: Cells utilize membrane-bound carriers to transport signaling molecules to their destinations, and variations in the genes encoding intracellular trafficking machinery can lead to craniofacial diseases. Despite the fundamental importance of trafficking pathways in craniofacial morphogenesis, there has been relatively less emphasis on this topic so far.
Review
Neurosciences
Daniela Ivanova, Michael A. Cousin
Summary: The endolysosomal system plays a crucial role in cells and inter-neuronal communication. It has been found that molecules involved in endolysosomal function are also important for the recycling of neurotransmitter-containing synaptic vesicles. Therefore, a rethinking of the understanding of membrane trafficking at the presynapse is proposed.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Cell Biology
Se-Jin Jeong, Jeremiah Stitham, Trent D. Evans, Xiangyu Zhang, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Joan Tao, Koki Takabatake, Slava Epelman, Irfan J. Lodhi, Joel D. Schilling, Brian J. Debosch, Abhinav Diwan, Babak Razani
Summary: The autophagy-lysosome system is crucial for recycling dysfunctional components in cells, and trehalose, a natural disaccharide, has the ability to induce autophagy by potentially affecting lysosomal function. This suggests that trehalose could serve as a therapeutic target for diseases associated with dysfunctional autophagy.
Article
Pharmacology & Pharmacy
Yunzhou Fan, Haoxun Wang, Zhou Yu, Zhengxuan Liang, Yufan Li, Guofeng You
Summary: Organic anion transporter 3 (OAT3) is a crucial transporter in the kidney proximal tubules that plays a key role in the systemic clearance of various substances. This study found that inhibiting the proteasome, but not the lysosome, increased the ubiquitination and transport activity of OAT3. Two anticancer drugs, bortezomib and carfilzomib, were used to further investigate the role of proteasome inhibition in OAT3 regulation. The results showed that inhibiting the proteasome enhanced OAT3 function by increasing its surface expression and transport activity. In vivo studies in rats confirmed these findings. These findings suggest that the proteasome could be a potential target for regulating OAT3 and could be used to treat OAT3-related conditions and ensure drug efficacy and safety.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Summary: The compartmentalization of eukaryotic cells is essential for their viability, with membranes forming boundaries between organelles and the cytosol. Cellular membranes can be compromised by various factors, but there are evolved mechanisms like membrane scission and endocytosis to maintain membrane integrity.
Article
Biochemistry & Molecular Biology
Roberta Romano, Cristina Rivellini, Maria De Luca, Rossana Tonlorenzi, Raffaella Beli, Fiore Manganelli, Maria Nolano, Lucio Santoro, Eeva-Liisa Eskelinen, Stefano C. Previtali, Cecilia Bucci
Summary: CMT2B, caused by mutations in the RAB7A gene, is a disease related to axonal peripheral neuropathy. Research showed that the endocytic pathway is altered in CMT2B patient cells, with increased lysosomal activity, potentially contributing to neurodegeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Editorial Material
Cell Biology
Kun Gao, Yingji Chen, Ren Mo, Chenji Wang
Summary: Mitophagy is important for cell survival, but excessive or uncontrolled mitophagy can lead to cell death. FBXL4 mutations are linked to mitochondrial DNA depletion syndrome, and the CRL1-FBXL4 complex regulates basal mitophagy.
Article
Cell Biology
Hyo Jeong Kim, Sun-Yong Kim, Dae-Ho Kim, Joon Seong Park, Seong Hyun Jeong, Young Won Choi, Chul-Ho Kim
Summary: This study reveals the degradation mechanism of AKT protein through ubiquitination and arginylation in cells, which is critical for cancer treatment. Modulating non-proteasomal proteolysis mechanisms like MUL1-mediated AKT ubiquitination may offer a novel therapeutic approach for cancer treatment.
Article
Biochemistry & Molecular Biology
Ya Zhuo, Joseph M. Crecelius, Adriano Marchese
Summary: This study provides evidence that distal carboxylterminal tail phosphorylation sites specify GRK-arrestin-mediated signaling in CXCR4 and other GPCRs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Plant Sciences
Julien Spielmann, Virginia Cointry, Fabienne Devime, Stephane Ravanel, Julie Neveu, Gregory Vert
Summary: This study revealed the regulatory mechanism of cadmium on IRT1, demonstrating that cadmium decreases cell surface levels of IRT1 through endocytosis and degradation with lower efficiency. The study also found that IRT1 endocytosis in response to cadmium is mediated through the direct binding of cadmium to histidine residues within the regulatory loop of IRT1, with lower affinity compared to other metal substrates.
Article
Cell Biology
Sayaka Yamamoto, Yuta Yako, Yoichiro Fujioka, Mihoko Kajita, Takeshi Kameyama, Shunsuke Kon, Susumu Ishikawa, Yusuke Ohba, Yusuke Ohno, Akio Kihara, Yasuyuki Fujita
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Multidisciplinary Sciences
Tamaki Yamada, Masumi Tsuda, Takanori Wagatsuma, Yoichiro Fujioka, Mari Fujioka, Aya O. Satoh, Kosui Horiuchi, Shinya Nishide, Asuka Nanbo, Yasunori Totsuka, Hisashi Haga, Shinya Tanaka, Masanobu Shindoh, Yusuke Ohba
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai, Shinya Tanaka, Mihoko Kajita, Susumu Ishikawa, Hajime Yamauchi, Yuta Yako, Tomoko Kamasaki, Tomohiro Matsumoto, Hirotaka Watanabe, Riku Egami, Ayana Sasaki, Atsuko Nishikawa, Ikumi Kameda, Takeshi Maruyama, Rika Narumi, Tomoko Morita, Yoshiteru Sasaki, Ryosuke Enoki, Sato Honma, Hiromi Imamura, Masanobu Oshima, Tomoyoshi Soga, Jun-ichi Miyazaki, Michael R. Duchen, Jin-Min Nam, Yasuhito Onodera, Shingo Yoshioka, Junichi Kikuta, Masaru Ishii, Masamichi Imajo, Eisuke Nishida, Yoichiro Fujioka, Yusuke Ohba, Toshiro Sato, Yasuyuki Fujita
NATURE CELL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Sayaka Saitoh, Takeshi Maruyama, Yuta Yako, Mihoko Kajita, Yoichiro Fujioka, Yusuke Ohba, Nobuhiro Kasai, Natsu Sugama, Shunsuke Kon, Susumu Ishikawa, Takashi Hayashi, Tomohiro Yamazaki, Masazumi Tada, Yasuyuki Fujita
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Microbiology
Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose, Tadaki Suzuki, Izumi Kato, Hideo Fukuhara, Mari Fujioka, Kosui Horiuchi, Aya O. Satoh, Prabha Nepal, Sayaka Kashiwagi, Jing Wang, Mika Horiguchi, Yuko Sato, Sarad Paudel, Asuka Nanbo, Tadaaki Miyazaki, Hideki Hasegawa, Katsumi Maenaka, Yusuke Ohba
CELL HOST & MICROBE
(2018)
Letter
Dermatology
Shinya Kitamura, Teruki Yanagi, Yuka Inamura-Takashima, Keisuke Imafuku, Hiroo Hata, Yoichiro Fujioka, Yusuke Ohba, Hiroshi Shimizu
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Microbiology
Asuka Nanbo, Junki Maruyama, Masaki Imai, Michiko Ujie, Yoichiro Fujioka, Shinya Nishide, Ayato Takada, Yusuke Ohba, Yoshihiro Kawaoka
Article
Multidisciplinary Sciences
Kazuhito V. Tabata, Yoshihiro Minagawa, Yuko Kawaguchi, Mana Ono, Yoshiki Moriizumi, Seiya Yamayoshi, Yoichiro Fujioka, Yusuke Ohba, Yoshihiro Kawaoka, Hiroyuki Noji
SCIENTIFIC REPORTS
(2019)
Article
Hematology
Takeshi Kondo, Mari Fujioka, Shinichi Fujisawa, Kaori Sato, Masumi Tsuda, Takuto Miyagishima, Akio Mori, Hiroshi Iwasaki, Yasutaka Kakinoki, Satoshi Yamamoto, Yoshihito Haseyama, Seisho Ando, Motohiro Shindo, Shuichi Ota, Mitsutoshi Kurosawa, Yusuke Ohba, Takanori Teshima
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2019)
Article
Cell Biology
Sayaka Kashiwagi, Yoichiro Fujioka, Aya O. Satoh, Aiko Yoshida, Mari Fujioka, Prabha Nepal, Atsushi Tsuzuki, Ozora Aoki, Sarad Paudel, Hitoshi Sasajima, Yusuke Ohba
CELL STRUCTURE AND FUNCTION
(2019)
Article
Cell Biology
Sayaka Kashiwagi, Yoichiro Fujioka, Takeshi Kondo, Aya O. Satoh, Aiko Yoshida, Mari Fujioka, Hitoshi Sasajima, Maho Amano, Takanori Teshima, Yusuke Ohba
CELL STRUCTURE AND FUNCTION
(2019)
Article
Cell Biology
Yoichiro Fujioka, Aya O. Satoh, Kosui Horiuchi, Mari Fujioka, Kaori Tsutsumi, Junko Sasaki, Prabha Nepal, Sayaka Kashiwagi, Sarad Paudel, Shinya Nishide, Asuka Nanbo, Takehiko Sasaki, Yusuke Ohba
CELL STRUCTURE AND FUNCTION
(2019)
Article
Oncology
Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo
Article
Cell Biology
Mika Horiguchi, Mari Fujioka, Takeshi Kondo, Yoichiro Fujioka, Xinxin Li, Kosui Horiuchi, Aya O. Satoh, Prabha Nepal, Shinya Nishide, Asuka Nanbo, Takanori Teshima, Yusuke Ohba
CELL STRUCTURE AND FUNCTION
(2017)
Review
Dentistry, Oral Surgery & Medicine
Yusuke Ohba, Yoichiro Fujioka
Journal of Oral Biosciences
(2016)