Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at α4β2 Nicotinic Acetylcholine Receptors

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors

(2014) Jeppe A. Olsen et al.   PLoS One

Two Distinct Allosteric Binding Sites at α4β2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors

(2013) Jeppe A. Olsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Unified Model of the GABAA Receptor Comprising Agonist and Benzodiazepine Binding Sites

(2013) Rikke Bergmann et al.   PLoS One

Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors

(2012) DB Timmermann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2nicotinic ACh receptors

(2012) M Grupe et al.   BRITISH JOURNAL OF PHARMACOLOGY

How theories evolved concerning the mechanism of action of barbiturates

(2012) Wolfgang Löscher et al.   EPILEPSIA

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Pharmacology, and Biostructural Characterization of Novel α4β2 Nicotinic Acetylcholine Receptor Agonists

(2012) Christine A. Ussing et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

(2012) Azadeh Shahsavar et al.   PLoS One

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors

(2011) Anshul Pandya et al.   BIOCHEMICAL PHARMACOLOGY

α4β2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of α4β2 nAChR agonists in pain

(2011) Chih-Hung Lee et al.   BIOCHEMICAL PHARMACOLOGY

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine α4β2 Receptors

(2011) Line Aagot Hede Rohde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors

(2011) K. Harpsoe et al.   JOURNAL OF NEUROSCIENCE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nicotinic acetylcholine receptors: an overview on drug discovery

(2009) Dieter D'hoedt et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Positive Allosteric Modulator Morantel Binds at Noncanonical Subunit Interfaces of Neuronal Nicotinic Acetylcholine Receptors

(2009) S. Seo et al.   JOURNAL OF NEUROSCIENCE

Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

(2009) D. Rayes et al.   JOURNAL OF NEUROSCIENCE

Nicotine binding to brain receptors requires a strong cation–π interaction

(2009) Xinan Xiu et al.   NATURE

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy

(2008) N. R. Mirza et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

(2008) T. T. Talley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA