Reactivation of Fetal Splicing Programs in Diabetic Hearts Is Mediated by Protein Kinase C Signaling

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

(2013) Hong Han et al.   NATURE

Vascular endothelial growth factor in heart failure

(2013) Ziad Taimeh et al.   Nature Reviews Cardiology

Coming full circle in diabetes mellitus: from complications to initiation

(2013) Brooke E. Harcourt et al.   Nature Reviews Endocrinology

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the alternative splicing of sarcoplasmic reticulum Ca2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway

(2012) Yimeng Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

(2012) Angela Oppelt et al.   EMBO REPORTS

Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects

(2012) Cammon B. Arrington et al.   European Journal of Medical Genetics

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function

(2012) L. T. Gehman et al.   GENES & DEVELOPMENT

Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation

(2012) Yusuke Kobayashi et al.   HYPERTENSION

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin αIIbβ3Activation and Granule Secretion in Platelets

(2012) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes and hypertension: the bad companions

(2012) Ele Ferrannini et al.   LANCET

The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus

(2012) Zhihong Zhou et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum

(2011) Moni Nader et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modeling Human Disease in Humans: The Ciliopathies

(2011) Gaia Novarino et al.   CELL

PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes

(2011) Yanan Liu et al.   CLINICAL SCIENCE

Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions

(2011) Thomas L. Gallagher et al.   DEVELOPMENTAL BIOLOGY

Return to the fetal gene program

(2010) Heinrich Taegtmeyer et al.   Annals of the New York Academy of Sciences

Alternative splicing is frequent during early embryonic development in mouse

(2010) Timothée Revil et al.   BMC GENOMICS

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

(2010) A. Kalsotra et al.   GENES & DEVELOPMENT

Genome-wide searching of rare genetic variants in WTCCC data

(2010) Tao Feng et al.   HUMAN GENETICS

Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA

(2010) E. Blackwell et al.   HUMAN MOLECULAR GENETICS

Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1

(2010) Misha Koshelev et al.   HUMAN MOLECULAR GENETICS

Calcium sensitivity, force frequency relationship and cardiac troponin I: Critical role of PKA and PKC phosphorylation sites

(2010) Genaro A. Ramirez-Correa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Analysis and design of RNA sequencing experiments for identifying isoform regulation

(2010) Yarden Katz et al.   NATURE METHODS

Alternative splicing and evolution: diversification, exon definition and function

(2010) Hadas Keren et al.   NATURE REVIEWS GENETICS

Global regulation of alternative splicing during myogenic differentiation

(2010) Christopher S. Bland et al.   NUCLEIC ACIDS RESEARCH

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity

(2010) Fulvia Terenzi et al.   RNA Biology

Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance

(2009) María E. Alzugaray et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

(2009) Melissa J. Moore et al.   CELL

Protein Kinase Cα, but Not PKCβ or PKCγ, Regulates Contractility and Heart Failure Susceptibility

(2009) Qinghang Liu et al.   CIRCULATION RESEARCH

Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

(2009) Kim A. Connelly et al.   Circulation-Heart Failure

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1

(2009) Guey-Shin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish

(2009) S. van't Padje et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

(2009) Gene W Yeo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors

(2009) Nathan Salomonis et al.   PLoS Computational Biology

Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options

(2008) Ashish Aneja et al.   AMERICAN JOURNAL OF MEDICINE

Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease

(2008) Kryn Stankunas et al.   CIRCULATION RESEARCH

Coding Sequence Mutations Identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 Patients with Familial or Idiopathic Dilated Cardiomyopathy

(2008) Ray E. Hershberger et al.   CTS-Clinical and Translational Science

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

(2008) A. Kalsotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA