Review
Biochemistry & Molecular Biology
Marjorie Lapouge, Sylvain Meloche
Summary: Most of our understanding about the involvement of SRC-family tyrosine kinases in cancer comes from studies on the SRC oncogene. However, recent research has highlighted the important role of YES signaling in cancer development, metastasis, therapy resistance, and poor outcomes. Abnormal expression or activity of YES is frequently observed in human cancers, making it a potential target for specific cancer subtypes. This review discusses the critical role of YES in cancer and the challenges of translating preclinical findings into effective YES-targeted therapies.
Article
Biotechnology & Applied Microbiology
F. Campioni, C. N. Gomes, A. M. M. Bergamini, D. P. Rodrigues, M. R. Tiba-Casas, J. P. Falcao
Summary: This study compared the ability of Salmonella enterica serovars Enteritidis and Dublin to invade, survive within, and stimulate cytokine release in various host cells. It found that compared to Enteritidis, Dublin has a stronger ability to survive within macrophages and induces weaker cytokine production, potentially explaining the differences in disease incidence caused by these two serovars.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Food Science & Technology
Xiaojie Qin, Yanhong Liu, Xianming Shi
Summary: The deletion of acrD in Salmonella Enteritidis decreases its resistance to egg white and results in cell lysis, while having no significant effect on adhesion and invasion ability compared to the wild type strain.
Article
Veterinary Sciences
Binjie Chen, Xianchen Meng, Jie Ni, Mengping He, Yanfei Chen, Pengpeng Xia, Heng Wang, Siguo Liu, Guoqiang Zhu, Xia Meng
Summary: Research shows that two RyhB paralogs of Salmonella enterica serovar Enteritidis can upregulate Type III secretion system (T3SS) effectors, affecting the bacteria's invasion into intestinal epithelial cells, and thereby impacting its virulence.
VETERINARY RESEARCH
(2021)
Review
Cell Biology
Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucur
Summary: C-terminal Src kinase (CSK) plays a crucial role in regulating critical cellular decisions, mainly through negative regulation of the SRC family of tyrosine kinases (SFKs) to promote apoptosis. Abnormal functioning of CSK and activation of SFKs are associated with diseases such as cancer, cardiovascular, and neurological disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Danny Alon, Yossi Paitan, Eyal Robinson, Nirit Ganor, Julia Lipovetsky, Rinat Yerushalmi, Cyrille J. Cohen, Annat Raiter
Summary: CD45, a predominant transmembrane tyrosine phosphatase in leukocytes, is crucial for T cell receptor signaling and activation, making it a potential therapeutic target. The immune modulating therapeutic peptide C24D can reset immune system functionality via the CD45 signaling pathway, showing potential immune reactivating effects on PBMCs from TNBC and COVID-19 patients. This study suggests CD45 as a potential therapeutic target due to its central role in the immune system.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Cynthia Meyer, Melissa McCoy, Lianbo Li, Bruce Posner, Kenneth D. Westover
Summary: Measurements of kinase activity are crucial for drug development and understanding drug resistance mechanisms. A label-free, high-throughput mass spectrometry-based assay is described for studying individual kinase enzymology and drug discovery. This approach is adaptable to various kinase substrates and offers increased sensitivity. It has the potential for research on understudied kinases and kinase drug discovery.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Review
Cell Biology
Yash Chhabra, Christine M. M. Lee, Alexandra Franziska Mueller, Andrew J. Brooks
Summary: This review summarizes the current knowledge on the activation, regulation, and downstream signaling of the GH receptor, focusing on the activation of SRC family kinases by GH and the different degradation mechanisms that can regulate GHR availability. Further studies on this area are warranted considering its role in tumor progression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Yan Ding, Guiping Wang, Meixiao Zhan, Xiaohan Sun, Yanran Deng, Yunhe Zhao, Bin Liu, Qingxin Liu, Shian Wu, Zizhang Zhou
Summary: Metastasis is a significant cause of mortality in malignant tumors, and understanding the molecular mechanisms involved can aid in the development of anti-cancer drugs. The Hippo pathway has been found to inhibit tumor cell metastasis, while inhibition of this pathway promotes tumor cell migration through activating SRC. Furthermore, the positive feedback loop between YAP and SRC also plays a crucial role in promoting hepatocellular carcinoma cell migration.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jing Guo, Xuxian Zhong, Qinglin Tan, Shengnan Yang, Jiaqi Liao, Jinke Zhuge, Ziyang Hong, Qiong Deng, Qiang Zuo
Summary: This study confirmed that ER stress induced the up-regulation of miR-301a-3p in HER2-positive GC cells, leading to Trastuzumab resistance. MiR-301a-3p mediated Trastuzumab resistance by down-regulating LRIG1 expression and subsequently activating IGF-1R and FGFR1 expression under ER stress. The intercellular transfer of miR-301a-3p by exosomes further disseminated Trastuzumab resistance.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Deisy Perdomo, Jose Bubis
Summary: The study identified the presence of Src family tyrosine kinases in dark-adapted retinas but found that the purified kinase was unable to use transducin as a substrate. This suggests that the specific cellular role of this retinal Src family member remains unknown.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2021)
Review
Cell Biology
Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah, Leszek Kotula
Summary: Despite over a century of scientific inquiry since the discovery of v-SRC, there is still no final judgement on SRC function. However, Src family kinases have been defined as key players in tumor progression, invasion and metastasis. Understanding the role of SFKs in mediating invasion and metastasis processes has grown along with the evidence supporting epithelial-mesenchymal transition (EMT) in these processes. This article describes key mechanisms through which SFKs play critical roles in epithelial homeostasis and propagate invasive signals.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Dan Ma, Ping Liu, Chujiao Hu, Zhen Zhou, Ping Wang, Yan Wang, Yaming Zhang, Yunsheng Ran, Pinghao Li, Jiangyuan Zhao, Jishi Wang, Chengliang Zhang, Lei Tang
Summary: This study revealed the important role of intracellular angiopoietin-1 (ANG-1) overexpression in drug resistance of chronic myeloid leukemia (CML), which promotes CML cell resistance through activation of the JAK/STAT pathway and enhancement of STAT5a phosphorylation. Therefore, intracellular ANG-1 may serve as a potential strategy for overcoming CML resistance.
Article
Cell & Tissue Engineering
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi
Summary: In this study, researchers found that immunoglobulin superfamily 11 (IgSF11) regulates osteoclast differentiation by controlling pyruvate kinase M isoform 2 (PKM2) activity. IgSF11 activates Src family tyrosine kinases (SFKs), which phosphorylate PKM2 and inhibit its activity. Activating PKM2 suppresses osteoclast differentiation and further prevents osteoclastic bone loss. These findings suggest that IgSF11-PKM2 pathway is important for optimal osteoclast maturation.
Article
Cell Biology
Beatriz Almaran, Guillem Ramis, Silvia Fernandez de Mattos, Priam Villalonga
Summary: In this study, the functional crosstalk between receptor tyrosine kinases (RTKs) and Rho GTPases was analyzed, with a focus on the specific contribution of Rnd3 to the invasive phenotype of glioblastoma cells. RTK inhibition decreased cell motility and invasion, and activated the RhoA/ROCK pathway for actin cytoskeletal reorganization. Rnd3 depletion had similar effects to RTK inhibition, suggesting its crucial role in regulating the invasive phenotype of glioblastoma cells through actin cytoskeletal reorganization.
Review
Microbiology
Agnes Wiedemann, Isabelle Virlogeux-Payant, Anne-Marie Chausse, Adam Schikora, Philippe Velge
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Agnes Wiedemann, Lily Mijouin, Mohammed Akli Ayoub, Emilie Barilleau, Sylvie Canepa, Ana Paula Teixeira-Gomes, Yves Le Vern, Manon Rosselin, Eric Reiter, Philippe Velge
Review
Immunology
Julien Mambu, Isabelle Virlogeux-Payant, Sebastien Holbert, Olivier Grepinet, Philippe Velge, Agnes Wiedemann
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Lily Mijouin, Manon Rosselin, Elisabeth Bottreau, Javier Pizarro-Cerda, Pascale Cossart, Philippe Velge, Agnes Wiedemann
Review
Microbiology
Zineb Boumart, Philippe Velge, Agnes Wiedemann
FEMS MICROBIOLOGY LETTERS
(2014)
Article
Biochemistry & Molecular Biology
Nadia Abed, Olivier Grepinet, Sylvie Canepa, Genaro A. Hurtado-Escobar, Nolwenn Guichard, Agnes Wiedemann, Philippe Velge, Isabelle Virlogeux-Payant
MOLECULAR MICROBIOLOGY
(2014)
Article
Gastroenterology & Hepatology
Eiji Nikaido, Etienne Giraud, Sylvie Baucheron, Suguru Yamasaki, Agnes Wiedemann, Kousuke Okamoto, Tatsuya Takagi, Akihito Yamaguchi, Axel Cloeckaert, Kunihiko Nishino
Article
Microbiology
P. Velge, A. Wiedemann, M. Rosselin, N. Abed, Z. Boumart, A. M. Chausse, O. Grepinet, F. Namdari, S. M. Roche, A. Rossignol, I. Virlogeux-Payant
Article
Microbiology
Geoffrey Bailleul, Rodrigo Guabiraba, Isabelle Virlogeux-Payant, Isabelle Lantier, Jerome Trotereau, Florence B. Gilbert, Agnes Wiedemann, Angelina Trotereau, Philippe Velge, Catherine Schouler, Anne-Christine Lalmanach
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Emilie Barilleau, Megane Vedrine, Michael Koczerka, Julien Burlaud-Gaillard, Florent Kempf, Olivier Grepinet, Isabelle Virlogeux-Payant, Philippe Velge, Agnes Wiedemann
Summary: PagN, a well-conserved protein among different species and subspecies of Salmonella, interacts with heparan sulfate proteoglycan (HSPG) to mediate invasion, but this interaction alone is not sufficient for internalization mechanism. Instead, PagN induces a phosphatidylinositol 3-kinase signaling pathway, leading to a Zipper-like entry mechanism similar to the Salmonella outer membrane protein Rck.
Article
Multidisciplinary Sciences
S. Holbert, E. Barilleau, S. M. Roche, J. Trotereau, S. Georgeault, J. Burlaud-Gaillard, A. Wiedemann, S. Meresse, I Virlogeux-Payant, P. Velge
Summary: Numerous studies have shown that the Salmonella Pathogenicity Island 1-encoded type III secretion system (T3SS1) apparatus and its associated effectors play a key role in the invasion and intracellular fate of Salmonella in host cells. Some cell lines have been identified where Salmonella Typhimurium can enter without using its three known invasion factors. In the murine AML12 hepatocyte cell line, the T3SS1 mutant induced an intracellular fate similar to the wild-type strain, indicating that invasion and survival of Salmonella Typhimurium can be independent of T3SS1.
SCIENTIFIC REPORTS
(2021)
Review
Microbiology
Sandrine Menard, Sonia Lacroix-Lamande, Katrin Ehrhardt, Jin Yan, Guntram A. Grassl, Agnes Wiedemann
Summary: Salmonella enterica serovars are invasive gram-negative bacteria that can cause a wide range of diseases. They gain access to the intestinal lumen and develop mechanisms to cross the intestinal epithelium and survive host defense mechanisms. This review focuses on the molecular dialogue between Salmonella Typhimurium (STm) and the intestinal epithelium, highlighting the mechanisms involved in crossing the intestinal epithelium and surviving host defense mechanisms.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Veterinary Sciences
Martin Beaumont, Fany Blanc, Claire Cherbuy, Giorgia Egidy, Elisabetta Giuffra, Sonia Lacroix-Lamande, Agnes Wiedemann
Summary: Culturing farm animal intestinal organoids has become a valuable tool in research, enabling efficient reduction of live animal use and exploration of physiological and pathological aspects of the intestine.
VETERINARY RESEARCH
(2021)
Article
Immunology
Julien Mambu, Emilie Barilleau, Laetitia Fragnet-Trapp, Yves Le Vern, Michel Olivier, Guillaume Sadrin, Olivier Grepinet, Frederic Taieb, Philippe Velge, Agnes Wiedemann
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Veterinary Sciences
Aurore Rossignol, Sylvie M. Roche, Isabelle Virlogeux-Payant, Agnes Wiedemann, Olivier Grepinet, Jennifer Fredlund, Jerome Trotereau, Olivier Marches, Pascale Quere, Jost Enninga, Philippe Velge
VETERINARY RESEARCH
(2014)