Review
Cell Biology
Kerry Woods, Carmen Perry, Francis Bruehlmann, Philipp Olias
Summary: Following invasion by Theileria sporozoites, one of the first events is the destruction of the host cell membrane and rapid association with host microtubules. Theileria species transform bovine cells by rewiring signaling pathways and controlling mitotic machinery. Theileria-encoded proteins can modify host gene expression, but their mode of action and secretion pathways are not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Ashraf Hussain, Eugene Boon Beng Ong, Prabha Balaram, Asma Ismail, Phua Kia Kien
Summary: Our study aimed to investigate the effects of deleting tolC on the adhesion and invasion of HT-29 epithelial cells and THP-1 macrophages by S. Typhi in vitro. Our results showed that the tolC mutant strain had significantly reduced adhesion and invasion rates compared to the wild-type strain in both cell types. Additionally, we observed downregulation of SPI-1 gene expression in the tolC mutant.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Jae-Min Yuk, Eun-Jin Park, In Soo Kim, Eun-Kyeong Jo
Summary: Itaconate is an important immunometabolite with anti-infective and anti-inflammatory properties. Its derivatives and isomers have potential as drugs for inflammation and infection. However, the exact mechanisms of action and the therapeutic potential of Itaconate are not fully understood due to contradictory results and a lack of clinical data. Further research is needed to understand how itaconate exerts its effects and to explore its therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaohui Li, Zonghui Zuo, Yihui Wang, Johannes H. Hegemann, Cheng He
Summary: Chlamydia psittaci is a gram-negative bacterium that causes systemic disease in birds, and its polymorphic membrane protein Pmp17G plays a crucial role in adhesion and invasion of host cells by interacting with EGFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daria Augustyniak, Eliza Kramarska, Pawel Mackiewicz, Magdalena Orczyk-Pawilowicz, Fionnuala T. Lundy
Summary: Neuropeptides play a crucial role in antimicrobial activities, acting as a double-edged sword by both combating microorganisms and potentially enhancing pathogenicity. Understanding the regulatory mechanisms of neuropeptides is essential for elucidating microbial pathogenesis processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Soren R. Paludan, Thomas Pradeu, Seth L. Masters, Trine H. Mogensen
Summary: This review compares and contrasts the inducible and constitutive mechanisms of immunosurveillance, showing the effectiveness and potential risks of immune responses, as well as the importance of maintaining homeostasis through a variety of immune mechanisms.
NATURE REVIEWS IMMUNOLOGY
(2021)
Review
Immunology
Nighat Perveen, Khalid Muhammad, Sabir Bin Muzaffar, Tean Zaheer, Nayla Munawar, Bojan Gajic, Olivier Andre Sparagano, Uday Kishore, Arve Lee Willingham
Summary: Haematophagous arthropods can carry various pathogens and transmit them to humans and animals, making it important to study their relationship with viruses. Insects have an innate immune system that helps them fight infections. The cellular components of haemolymph, called haemocytes, play a central role in the insect immune system. Mosquitoes and ticks, blood-feeding arthropods, can transmit viral pathogens to their hosts. Despite the arthropod vectors' complex immune response, the viruses can still survive and be transmitted. A multidisciplinary approach is needed to control ectoparasite infestations and prevent vector-borne transmission of viral pathogens to humans and animals.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuanze Gao, Helin Chen, Wen Li, Yu Zhang, Jie Luo, Ling Zhao, Fei Shi, Gang Ye, Xiaoli He, Zhiwen Xu, Ling Zhu, Huaqiao Tang, Yinglun Li
Summary: This study evaluated the effect of chloroform extracts from Atractylodes chinensis on the virulence of Salmonella Typhimurium (STM) and found that it could attenuate the adhesion and invasion abilities of STM, as well as inhibit the expression of genes related to adhesion and invasion. It also downregulated the expression of inflammatory cytokines and restored the expression of intestinal barrier-related genes and proteins damaged during STM infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Leon Kemper, Andreas Hensel
Summary: Campylobacter jejuni, causing severe enteritis, has unique features and adapts effectively to environmental conditions. The review summarizes the strategies of C. jejuni for host-pathogen interaction, providing insights for future drug development.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Multidisciplinary Sciences
Nisrine Chelkha, Anthony Levasseur, Bernard La Scola, Philippe Colson
Summary: Giant viruses challenge the traditional view of the virosphere with their large size and complex interactions with hosts, exhibiting defense mechanisms against hosts and competing microorganisms. Comparative genomics may aid in identifying genes involved in defense strategies against giant viruses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Parasitology
Yakun Wang, Xue Zhou, Hanzhu Wang, Lingyu Sun, Bingxiang Wang, Yingying Jiang, Huihui Li, Xiao Zhang, Hongmei Li, Xiaomin Zhao
Summary: The study cloned and investigated the membrane-associated calcium-binding protein EtCab in Eimeria tenella, showing high expression on sporozoites and involvement in attachment and invasion of host cells.
VETERINARY PARASITOLOGY
(2021)
Article
Microbiology
Kristin Scoggin, Jyotsana Gupta, Rachel Lynch, Aravindh Nagarajan, Manuchehr Aminian, Amy Peterson, L. Garry Adams, Michael Kirby, David W. Threadgill, Helene L. Andrews-Polymenis
Summary: Understanding the molecular mechanisms of resistance and tolerance to pathogen infection can help in developing novel interventions. A study on mice infected with Salmonella Typhimurium found distinct phenotypes of delayed susceptible, tolerant, and resistant strains. Tolerant strains showed lower preinfection core body temperatures, rapid disruption of body temperature postinfection, higher neutrophil levels, and more severe tissue damage compared to resistant strains. Gene analysis identified specific genes associated with tolerance and resistance, particularly fibrinogen genes.
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Varnesh Tiku
Summary: Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen causing severe and life-threatening infections, categorized as a high-priority pathogen by WHO. Its ability to tolerate high stress levels and exhibit high degrees of antibiotic resistance make it a serious pathogen.
DNA AND CELL BIOLOGY
(2022)
Article
Fisheries
Jianhong Ouyang, Yiyun Zhu, Weijing Hao, Xia Wang, Huaixin Yang, Xinyi Deng, Tingting Feng, Yong Huang, Haining Yu, Yipeng Wang
Summary: In this study, three host defense peptides (HDPs) exhibited potent and broad-spectrum antimicrobial activity against aquatic pathogenic bacteria and effectively modulated anti-infective immune responses in largemouth bass. They also showed potential in combating biofilm-related infections and significantly enhancing the survival rate of bacteria-challenged largemouth bass while decreasing bacterial resistance compared to conventional antibiotics. These results suggest the promising use of these HDPs as novel anti-infective agents in largemouth bass culture.
Article
Entomology
Gwendolin Wehner, Adam Schikora, Frank Ordon, Torsten Will
Summary: Plants have developed numerous strategies to respond to stresses, with the microbiota surrounding plants potentially playing a positive role. Reacting to rhizobacteria can induce systemic resistance in plants, showing effects on pest feeding behaviors and plant biomass. Sensitivity to priming may offer a new approach for plant breeding to enhance resistance against multiple pests.
JOURNAL OF PEST SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Azhar A. Zarkani, Adam Schikora
Summary: The interaction between Salmonella and crop plants is a global health concern, with the bacterium utilizing multiple strategies to manipulate host defense systems and successfully colonize plants while avoiding plant defense responses. Understanding these mechanisms has significant implications for plant production systems in terms of growth, harvest, and processing steps. Efforts to prevent crop plant contamination are essential in minimizing or eliminating the potential for human diseases.
Editorial Material
Microbiology
Soumitra Paul Chowdhury, Laszlo Kredics, Fred O. Asiegbu, Beatriz Lagunas, Adam Schikora
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Nina Bziuk, Lorrie Maccario, Benjamin Straube, Gwendolin Wehner, Soren J. Sorensen, Adam Schikora, Kornelia Smalla
Summary: The genotype of barley significantly influences both the seed and rhizosphere microbiota. The core seed microbiome contains dominant bacterial genera, and many endophytic isolates show plant beneficial properties through the production of secondary metabolites. New breeding strategies should prioritize genotypes with a high abundance of beneficial microbes.
ENVIRONMENTAL MICROBIOME
(2021)
Article
Engineering, Environmental
Nicolas Grosjean, Marie Le Jean, Jean Armengaud, Adam Schikora, Michel Chalot, Elisabeth M. Gross, Damien Blaudez
Summary: The extensive use and release of rare earth elements have raised concerns about environmental and ecosystem impacts. Studies have revealed differences in the molecular responses of the model organism Saccharomyces cerevisiae to lanthanum and ytterbium, affecting multiple crucial biological metabolic pathways and signaling pathways.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Plant Sciences
Sophie Hermann, Marc Orlik, Petra Boevink, Elke Stein, Andrea Scherf, Ina Kleeberg, Annegret Schmitt, Adam Schikora
Summary: The study demonstrates that licorice leaf extract can be an effective alternative to conventional pesticides, acting as a fungicide and bactericide and modulating the plant immune system to combat pathogen infections.
Article
Microbiology
Helit Cohen, Claire Hoede, Felix Scharte, Charles Coluzzi, Emiliano Cohen, Inna Shomer, Ludovic Mallet, Sebastien Holbert, Remy Felix Serre, Thomas Schiex, Isabelle Virlogeux-Payant, Guntram A. Grassl, Michael Hensel, Helene Chiapello, Ohad Gal-Mor
Summary: Salmonella enterica includes various serovars causing distinct diseases in humans. In this study, we compared the global gene expression and intracellular phenotypes of S. Typhimurium (STM) and S. Paratyphi A (SPA), representative serovars of non-typhoidal and typhoidal Salmonella, during human epithelial cell infection. We found different expression patterns in key virulence and metabolic pathways, cytosolic motility, and reinvasion ability of SPA after exiting infected cells. These differences may contribute to the invasive and systemic disease developed following SPA infection in humans.
Article
Microbiology
Nina Bziuk, Lorrie Maccario, Soren J. Sorensen, Adam Schikora, Kornelia Smalla
Summary: This study investigated the effects of rhizosphere microbiome transplant (RMT) on the immune response and disease rates of barley. The results showed that the RMT-treated barley exhibited lower susceptibility to the fungal pathogen and increased expression of defense-related genes. Furthermore, the composition and function of the rhizosphere microbiome were influenced by the transplant, resulting in higher microbial diversity.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Sandrine Menard, Sonia Lacroix-Lamande, Katrin Ehrhardt, Jin Yan, Guntram A. Grassl, Agnes Wiedemann
Summary: Salmonella enterica serovars are invasive gram-negative bacteria that can cause a wide range of diseases. They gain access to the intestinal lumen and develop mechanisms to cross the intestinal epithelium and survive host defense mechanisms. This review focuses on the molecular dialogue between Salmonella Typhimurium (STm) and the intestinal epithelium, highlighting the mechanisms involved in crossing the intestinal epithelium and surviving host defense mechanisms.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Nikola Major, Jasper Schierstaedt, Adam Schikora, Igor Palcic, Marko Cerne, Smiljana Goreta Ban, Igor Paskovic, Josipa Perkovic, Zoran Uzila, Dean Ban
Summary: The addition of compost or biochar to soils is an effective strategy to increase soil organic matter. Turning sewage sludge into compost or biochar can help mitigate its negative effects on soil and provide a viable solution for sewage sludge management.
Article
Biology
Abhishek Shrestha, Casandra Hernandez-Reyes, Maja Grimm, Johannes Krumwiede, Elke Stein, Sebastian T. Schenk, Adam Schikora
Summary: This study identifies the Arabidopsis protein ALI1 as a mediator of oxo-C14-HSL-induced priming for enhanced resistance in plants. The researchers found that the loss of the ALI1 gene resulted in the loss of AHL priming, which was restored by the reintroduction of ALI1. The study also suggests that ALI1 may interact with oxo-C14-HSL. These findings advance our understanding of plant-bacteria interactions and provide insights for enhancing stress resistance in crops.
Article
Plant Sciences
Duan Yongming, Min Han, Maja Grimm, Jessica Ponath, Michael Reichelt, Axel Mithoefer, Adam Schikora
Summary: N-acyl homoserine lactones (AHLs) are important molecules in plant-bacteria interactions. AHL-producing bacteria can enhance plant growth and resistance against pathogens. This study investigates the mechanism of AHL-priming using a mixture of AHL molecules and AHL-producing bacteria on Arabidopsis. Understanding AHL-priming can contribute to sustainable agriculture and plant protection against pathogens.
Article
Engineering, Environmental
Nikola Major, Sven Jechalke, Joseph Nesme, Smiljana Goreta Ban, Marko Cerne, Soren J. Sorensen, Dean Ban, Rita Grosch, Adam Schikora, Jasper Schierstaedt
Summary: Municipal sewage sludge and other biosolids have high potential as organic fertilizers in agriculture, but their use is limited by the presence of heavy metal and organic compound pollutants. This study investigated the impact of stabilization method and wastewater treatment plant size on microbial community structure and gene abundance, finding antibiotic resistance genes and mobile genetic elements in all samples. The presence of certain heavy metals correlated with the presence of antibiotic resistance genes. It is important to assess pollutants and long-term effects before considering the use of sewage sludge as fertilizer.
Article
Microbiology
Jerome Trotereau, Romain Jouan, Delphine Naquin, Maxime Branger, Catherine Schouler, Philippe Velge, Peter Mergaert, Isabelle Virlogeux-Payant
Summary: In this study, a high-density transposon sequencing library of the Salmonella Typhimurium ATCC 14028 strain was constructed and characterized, and essential genes for growth in rich culture medium were identified.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Nina Bziuk, Lorrie Maccario, Dimitar Douchkov, Stefanie Lueck, Doreen Babin, Soren J. Sorensen, Adam Schikora, Kornelia Smalla
Summary: Long-term agricultural practices shape the rhizosphere microbiome of crops, impacting plant health. Differences in microbial community composition are influenced by tillage practices rather than fertilization intensity. Higher microbial diversity in field soils compared to potting soils may contribute to lower infection rates of barley grown in field soil.
FEMS MICROBIOLOGY ECOLOGY
(2021)