Smad7 Protein Induces Interferon Regulatory Factor 1-dependent Transcriptional Activation of Caspase 8 to Restore Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis

FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma

(2012) Kathrin Geiger et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct TRAIL Resistance Mechanisms Can Be Overcome by Proteasome Inhibition but not Generally by Synergizing Agents

(2011) C. Menke et al.   CANCER RESEARCH

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

(2011) Masato Morikawa et al.   NUCLEIC ACIDS RESEARCH

High Throughput Determination of TGFβ1/SMAD3 Targets in A549 Lung Epithelial Cells

(2011) Yingze Zhang et al.   PLoS One

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

ChIP-seq Defined Genome-Wide Map of TGFβ/SMAD4 Targets: Implications with Clinical Outcome of Ovarian Cancer

(2011) Brian A. Kennedy et al.   PLoS One

Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation

(2010) Yanyuan Wu et al.   BMC CANCER

Improved Antitumor Activity and Tumor Targeting of NH2-Terminal-Specific PEGylated Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

(2010) S. Y. Chae et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Pancreatic Stellate Cell Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development

(2010) Itai Spector et al.   PANCREAS

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

(2010) Jing Xu et al.   PLoS One

Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting Specifically Through the Caspase-8 Apoptotic Axis

(2010) Darren Finlay et al.   PLoS One

Halofuginone enhances the radiation sensitivity of human tumor cell lines

(2009) John A. Cook et al.   CANCER LETTERS

A ChIP–chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response

(2009) Mattia Frontini et al.   NUCLEIC ACIDS RESEARCH

MH1 domain of SMAD4 binds N-terminal residues of the homeodomain of Hoxc9

(2008) Bo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS