Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

(2010) Katrien Brak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases

(2009) Clifford Bryant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Guided Development of Selective TbcatB Inhibitors

(2009) Jeremy P. Mallari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

(2008) Jeremy P. Mallari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

(2008) Theresa C. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB

(2008) Jeremy P. Mallari et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

(2008) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Differential use of protease families for invasion by schistosome cercariae

(2007) Jan Dvořák et al.   BIOCHIMIE