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Biochemistry & Molecular Biology
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan
Summary: Nradd, a negative regulator of Wnt/beta-catenin signaling, suppresses Wnt-mediated patterning in zebrafish embryos and mammalian cells, highlighting its role in regulating cell growth and development through modulating Wnt signaling and apoptosis.
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Pharmacology & Pharmacy
Divya Adiga, Samatha Bhat, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
Summary: DOC2B inhibits the Wnt/beta-catenin pathway by enhancing CTNNB1 destruction complex components expression and promoting CTNNB1 degradation. It perturbs CTNNB1 translocation and interaction with transcription factors independently of GSK3beta. The activation of DOC2B-DKK1-senescence-Wnt/beta-catenin-EMT signaling crosstalk may provide a novel approach to restrain malignant behaviors in cervical cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Shiyu Chen, Zhonglin Jia, Ming Cai, Mujie Ye, Dandan Wu, Teng Wan, Bowen Zhang, Peixuan Wu, Yuexin Xu, Yuntao Guo, Chan Tian, Duan Ma, Jing Ma
Summary: The study found that lncRNA ZFAS1 was significantly upregulated in NSCLP and mediated by SP1, inhibiting the WNT/β-catenin signaling pathway to affect cell proliferation, migration, and chondrogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wei Xie, Huijie Zhao, Fengxian Wang, Yiyun Wang, Yuan He, Tong Wang, Kunchi Zhang, Hao Yang, Zhaoli Zhou, Haibin Shi, Jin Wang, Gang Huang
Summary: A novel humanized antibody targeting Fzd7, named SHH002-hu1, was developed and demonstrated potential anti-tumor activity. It showed high affinity with Fzd7, specifically targeted Fzd7(+) cells and tumor tissues, and enhanced the anti-TNBC capacity of Bevacizumab through inhibiting Wnt/beta-catenin signaling. SHH002-hu1 could be a promising candidate for synergistic therapy with Bevacizumab in preventing TNBC recurrence.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kuangen Zhang, Rui Wu, Fang Mei, Yuhe Zhou, Lin He, Yanhua Liu, Xuyang Zhao, Jiangfeng You, Beiying Liu, Qingyang Meng, Fei Pei
Summary: LASS2 acts as a tumor-suppressor gene in prostate cancer by promoting beta-catenin degradation through physical interaction with specific proteins, and phosphorylation of LASS2 at a specific residue plays a crucial role in inhibiting cancer cell growth and metastasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Hiroki Tage, Kiyoshi Yamaguchi, Saya Nakagawa, So Kasuga, Kiyoko Takane, Yoichi Furukawa, Tsuneo Ikenoue
Summary: In this study, novel target genes of the Wnt/β-catenin signaling pathway were identified in cancer cells. One of these genes, Visinin-like 1 (VSNL1), was found to be regulated by the β-catenin/TCF7L2 complex via TCF7L2-binding elements and involved in apoptosis resistance in colorectal cancer cells.
Article
Cell Biology
Shi Wei, Miaomiao Dai, Chi Zhang, Kai Teng, Fengwei Wang, Hongbo Li, Weipeng Sun, Zihao Feng, Tiebang Kang, Xinyuan Guan, Ruihua Xu, Muyan Cai, Dan Xie
Summary: This study showed that KIF2C is significantly upregulated in HCC and associated with poor prognosis. Functional assays revealed that KIF2C promotes HCC cell proliferation, migration, invasion, and metastasis. Mechanistically, the study identified TBC1D7 as a binding partner of KIF2C, disrupting TSC complex formation and enhancing mTORC1 signaling.
Article
Engineering, Biomedical
Xianquan Feng, Jialiang Zhang, Lina Wu, Wanjing Lin, Zhihong Liu, Xin Zhou, Yang Qi, Zhenzhen Chen, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Qian Zhang, Hongtao Song
Summary: This study evaluates the role of drug self-delivery nanocubes (ATO/PpIX-SMN) combined with anti-PD-L1 in TNBC treatment. The nanocubes enhance photodynamic therapy-induced immunogenic cell death and downregulate tumor signaling. Combined with anti-PD-L1, they promote dendritic cell maturation, increase CTL infiltration, reduce regulatory T cells, and activate the host immune system, effectively treating primary and distal tumors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Liao, Susann Badmann, Fabian Kraus, Nicole Elisabeth Topalov, Doris Mayr, Thomas Kolben, Anna Hester, Susanne Beyer, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla, Alexander Burges
Summary: This study investigates the role of platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in the Wnt signaling pathway in BRCA1 mutant breast cancer. The results show significantly higher nuclear expression levels of PAF-AH in BRCA1 mutant tissue specimens, which correlates with membranous beta-catenin. PLA2G7 silencing leads to translocation of beta-catenin from the membrane to the nucleus and activation of Wnt signaling downstream genes. These findings suggest a protective effect of high PAF-AH expression in BRCA1 mutant breast cancer through negative regulation of the Wnt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiao Ma, Xiaoling Hu, Yijia Zhu, Huixian Jin, Guifen Hu, Linchao Ding, Shilong Ning
Summary: Sesamol inhibits proliferation, migration, and invasion of triple negative breast cancer (TNBC) cells by attenuating PCNA, CyclinD1 expression and reverting epithelial-mesenchymal transition (EMT). It also inactivates the Wnt/beta-catenin signaling pathway and induces the expression of Wnt inhibitory factor 1 (WIF1), which leads to the inhibition of TNBC growth and metastasis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Cell Biology
Marc Gentzel, Carolin Schille, Verena Rauschenberger, Alexandra Schambony
MOLECULAR BIOLOGY OF THE CELL
(2015)
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Developmental Biology
Carolin Schille, Jens Heller, Alexandra Schambony
BMC DEVELOPMENTAL BIOLOGY
(2016)
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Biochemistry & Molecular Biology
Nina Larisch, Sonja A. Kirsch, Alexandra Schambony, Tanja Studtrucker, Rainer A. Boeckmann, Petra Dietrich
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
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Oncology
Annalen Bleckmann, Lena-Christin Conradi, Kerstin Menck, Nadine Annette Schmick, Antonia Schubert, Eva Rietkoetter, Jetcy Arackal, Peter Middel, Alexandra Schambony, Torsten Liersch, Kia Homayounfar, Tim Beissbarth, Florian Klemm, Claudia Binder, Tobias Pukrop
CLINICAL & EXPERIMENTAL METASTASIS
(2016)
Article
Developmental Biology
Carolin Schille, Michaela Bayerlova, Annalen Bleckmann, Alexandra Schambony
Article
Biochemistry & Molecular Biology
D. Mielenz, M. Reichel, T. Jia, E. B. Quinlan, T. Stoeckl, M. Mettang, D. Zilske, E. Kirmizi-Alsan, P. Schoenberger, M. Praetner, S. E. Huber, D. Amato, M. Schwarz, P. Purohit, S. Brachs, J. Spranger, A. Hess, C. Buettner, A. B. Ekici, F. Perez-Branguli, B. Winner, V. Rauschenberger, T. Banaschewski, A. L. W. Bokde, C. Buechel, P. J. Conrod, S. Desrivieres, H. Flor, V. Frouin, J. Gallinat, H. Garavan, P. Gowland, A. Heinz, J-L Martinot, H. Lemaitre, F. Nees, T. Paus, M. N. Smolka, A. Schambony, T. Baeuerle, V. Eulenburg, C. Alzheimer, A. Lourdusamy, G. Schumann, C. P. Mueller
MOLECULAR PSYCHIATRY
(2018)
Article
Cell Biology
Dominic B. Bernkopf, Kowcee Jalal, Martina Brueckner, Karl X. Knaup, Marc Gentzel, Alexandra Schambony, Juergen Behrens
JOURNAL OF CELL BIOLOGY
(2018)
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Biochemistry & Molecular Biology
Ondrej Bernatik, Katerina Sedova, Carolin Schille, Ranjani Sri Ganji, Igor Cervenka, Lukas Trantirek, Alexandra Schambony, Zbynek Zdrahal, Vitezslav Bryja
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Maria Kotini, Elias H. Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambon, Roberto Mayor
NATURE COMMUNICATIONS
(2018)
Correction
Multidisciplinary Sciences
Maria Kotini, Elias H. Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambony, Roberto Mayor
NATURE COMMUNICATIONS
(2018)
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Optics
Richard W. Taylor, Reza Gholami Mahmoodabadi, Verena Rauschenberger, Andreas Giessl, Alexandra Schambony, Vahid Sandoghdar
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Multidisciplinary Sciences
Jakub Harnos, Maria Consuelo Alonso Canizal, Miroslav Jurasek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Katerina Hanakova, Ondrej Bernatik, Zbynek Zdrahal, Kristina Gomoryova, Tomas Gybel, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukas Trantirek, Jan Rynes, Zankruti Dave, Ana Iris Fernandez-Llamazares, Robert Vacha, Konstantinos Tripsianes, Carsten Hoffmann, Vitezslav Bryja
NATURE COMMUNICATIONS
(2019)
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Developmental Biology
Angela Prager, Cathrin Hagenlocher, Tim Ott, Alexandra Schambony, Kerstin Feistel
DEVELOPMENTAL BIOLOGY
(2017)
Article
Developmental Biology
Verena Rauschenberger, Dominic B. Bernkopf, Sabrina Krenn, Kowcee Jalal, Jens Heller, Juergen Behrens, Marc Gentzel, Alexandra Schambony
Review
Cell Biology
Marc Gentzel, Alexandra Schambony
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2017)