Probing molecular choreography through single-molecule biochemistry

Single-Molecule Imaging at High Fluorophore Concentrations by Local Activation of Dye

(2015) Hylkje J. Geertsema et al.   BIOPHYSICAL JOURNAL

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

A Dynamic Search Process Underlies MicroRNA Targeting

(2015) Stanley D. Chandradoss et al.   CELL

Chikungunya virus fusion properties elucidated by single-particle and bulk approaches

(2015) Mareike K. S. van Duijl-Richter et al.   JOURNAL OF GENERAL VIROLOGY

Combining Single-Molecule Imaging and Single-Channel Electrophysiology

(2015) Eve E. Weatherill et al.   JOURNAL OF MOLECULAR BIOLOGY

Imaging Live-Cell Dynamics and Structure at the Single-Molecule Level

(2015) Zhe Liu et al.   MOLECULAR CELL

Replisome speed determines the efficiency of the Tus−Ter replication termination barrier

(2015) Mohamed M. Elshenawy et al.   NATURE

Transport domain unlocking sets the uptake rate of an aspartate transporter

(2015) Nurunisa Akyuz et al.   NATURE

Direct observation of structure-function relationship in a nucleic acid-processing enzyme

(2015) M. J. Comstock et al.   SCIENCE

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

DNA replication at the single-molecule level

(2014) S. A. Stratmann et al.   CHEMICAL SOCIETY REVIEWS

Molecular Crowding Accelerates Ribozyme Docking and Catalysis

(2014) Bishnu P. Paudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level

(2014) Jason J. Otterstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

Visualization of Membrane Fusion, One Particle at a Time

(2013) Jason Otterstrom et al.   BIOCHEMISTRY

New approaches for sensing metabolites and proteins in live cells using RNA

(2013) Rita L Strack et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An Optical Trap Combined with Three-Color FRET

(2013) Sanghwa Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

(2013) Guus B. Erkens et al.   NATURE

Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies

(2013) Andrew Robinson et al.   NATURE REVIEWS MICROBIOLOGY

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

(2013) Tijana Ivanovic et al.   eLife

Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target

(2012) Andrew Robinson et al.   CURRENT DRUG TARGETS

A general approach to break the concentration barrier in single-molecule imaging

(2012) Anna B Loveland et al.   NATURE METHODS

Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog

(2012) Grégory Verdon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

E. coliDNA replication in the absence of free β clamps

(2011) Nathan A Tanner et al.   EMBO JOURNAL

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central dogma at the single-molecule level in living cells

(2011) Gene-Wei Li et al.   NATURE

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

Ultrahigh-resolution optical trap with single-fluorophore sensitivity

(2011) Matthew J Comstock et al.   NATURE METHODS

Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange

(2011) Joseph J. Loparo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Properties and identification of antibiotic drug targets

(2010) Tala M Bakheet et al.   BMC BIOINFORMATICS

Macromolecule diffusion and confinement in prokaryotic cells

(2010) Jacek T Mika et al.   CURRENT OPINION IN BIOTECHNOLOGY

Models of macromolecular crowding effects and the need for quantitative comparisons with experiment

(2010) Adrian H Elcock   CURRENT OPINION IN STRUCTURAL BIOLOGY

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

Prediction of the human membrane proteome

(2010) Linn Fagerberg et al.   PROTEOMICS

S. aureus MscL Is a Pentamer In Vivo but of Variable Stoichiometries In Vitro: Implications for Detergent-Solubilized Membrane Proteins

(2010) Michael R. Dorwart et al.   PLOS BIOLOGY

Genetically encoded biosensors based on engineered fluorescent proteins

(2009) Wolf B. Frommer et al.   CHEMICAL SOCIETY REVIEWS

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Single-Molecule Approach to Molecular Biology in Living Bacterial Cells

(2008) X. Sunney Xie et al.   Annual Review of Biophysics

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Crowding Effects on Diffusion in Solutions and Cells

(2008) James A. Dix et al.   Annual Review of Biophysics

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

Single-particle kinetics of influenza virus membrane fusion

(2008) D. L. Floyd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed single-molecule measurements with magnetic tweezers

(2008) Noah Ribeck et al.   REVIEW OF SCIENTIFIC INSTRUMENTS