Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate

Allosteric Coupling in Pyruvate Dehydrogenase Kinase 2†

(2008) Alla Klyuyeva et al.   BIOCHEMISTRY

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2

(2008) Todd Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

(2008) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance

(2008) Chun-Wun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

(2008) Masato Kato et al.   STRUCTURE