In Vitro Effects of Some Flavones on Human Pyruvate Kinase Isoenzyme M2

Flavones: An important scaffold for medicinal chemistry

(2014) Manjinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)

(2013) Yong Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flavonoids as prospective compounds for anti-cancer therapy

(2013) Divyashree Ravishankar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anticancer Agents That Counteract Tumor Glycolysis

(2012) Carlotta Granchi et al.   ChemMedChem

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Enzymatic features of the glucose metabolism in tumor cells

(2011) Anique Herling et al.   FEBS Journal

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2010) Jian-kang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human pyruvate kinase M2: A multifunctional protein

(2010) Vibhor Gupta et al.   PROTEIN SCIENCE

New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

(2008) Min Li-Weber   CANCER TREATMENT REVIEWS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE