Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues

Biologics for tendon repair

(2015) Denitsa Docheva et al.   ADVANCED DRUG DELIVERY REVIEWS

Gene therapy enters the pharma market: The short story of a long journey

(2013) Hildegard Büning   EMBO Molecular Medicine

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres

(2013) Corinne Sonnet et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Advances in Regenerative Orthopedics

(2013) Christopher H. Evans   MAYO CLINIC PROCEEDINGS

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

(2012) Chul-Won Ha et al.   CYTOTHERAPY

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

Enhanced Adenovirus Transduction of hMSCs Using 3D Hydrogel Cell Carriers

(2012) Alexander J. Neumann et al.   MOLECULAR BIOTECHNOLOGY

Orthopedic gene therapy-lost in translation?

(2011) C.H. Evans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo

(2011) Patrick Orth et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

“Same Day” Ex-vivo Regional Gene Therapy: A Novel Strategy to Enhance Bone Repair

(2011) Mandeep S Virk et al.   MOLECULAR THERAPY

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

(2011) M.I. Menendez et al.   OSTEOARTHRITIS AND CARTILAGE

Heterotopic ossifications following implant surgery—epidemiology, therapeutical approaches and current concepts

(2011) Christian Zeckey et al.   Seminars in Immunopathology

Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model

(2011) Steven K. Leckie et al.   Spine Journal

Baculovirus as a Gene Delivery Vector for Cartilage and Bone Tissue Engineering

(2010) Chin-Yu Lin et al.   CURRENT GENE THERAPY

Articular cartilage repair by genetically modified bone marrow aspirate in sheep

(2010) A Ivkovic et al.   GENE THERAPY

Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model

(2010) A Ishihara et al.   GENE THERAPY

The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo

(2009) Nadav Kimelman-Bleich et al.   BIOMATERIALS

Clinical Responses to Gene Therapy in Joints of Two Subjects with Rheumatoid Arthritis

(2009) Peter Wehling et al.   HUMAN GENE THERAPY

Heterotopic Ossification in High-Energy Wartime Extremity Injuries: Prevalence and Risk Factors

(2009) Jonathan Agner Forsberg et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Safety, Tolerability, and Clinical Outcomes after Intraarticular Injection of a Recombinant Adeno-associated Vector Containing a Tumor Necrosis Factor Antagonist Gene: Results of a Phase 1/2 Study

(2009) P. J. MEASE et al.   JOURNAL OF RHEUMATOLOGY

Application of tissue-engineered cartilage with BMP-7 gene to repair knee joint cartilage injury in rabbits

(2009) J. H. Che et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor   antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study

(2008) P J Mease et al.   ANNALS OF THE RHEUMATIC DISEASES

Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering

(2008) J Sohier et al.   Expert Opinion on Drug Delivery

Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models

(2008) Akikazu Ishihara et al.   JOURNAL OF ORTHOPAEDIC RESEARCH