Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Hongyan Wu, Xinyi Tang, Hyo Jin Kim, Shahrzad Jalali, Joshua C. Pritchett, Jose C. Villasboas, Anne J. Novak, Zhi-Zhang Yang, Stephen M. Ansell
Summary: The study found that intratumoral CD8(+) cells in FL are skewed toward effector cell subsets, exhibiting increased capacity to produce cytokines/granules compared to memory cell subsets, but with inferior proliferative and viability capacities. The distribution of different CD8(+) cell subsets is associated with the prognosis of patients with FL.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Rheumatology
Cristina M. Padilla, Eleanor Valenzi, Tracy Tabib, Banafsheh Nazari, John Sembrat, Mauricio Rojas, Patrizia Fuschiotti, Robert Lafyatis
Summary: This study analyzed lymphoid subpopulations in SSc-ILD lung tissue using single-cell RNA sequencing and found activated NK cells, CD8(+) tissue resident memory T cells, and Treg cells in SSc-ILD lungs. The transition of CD8(+) T cells to tissue resident memory phenotype was observed in SSc-ILD.
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Review
Immunology
Sara Bolivar-Wagers, Jemma H. Larson, Sujeong Jin, Bruce R. Blazar
Summary: Treg cells play a critical role in maintaining immune homeostasis and tolerance induction; however, the mechanisms responsible for their cytotoxicity and therapeutic potential have not been fully explored.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Alejandro J. Cagnoni, Maria Laura Giribaldi, Ada G. Blidner, Anabela M. Cutine, Sabrina G. Gatto, Rosa M. Morales, Mariana Salatino, Martin C. Abba, Diego O. Croci, Karina V. Marino, Gabriel A. Rabinovich
Summary: Colorectal cancer is a common malignancy with limited response to immunotherapy, prompting the need for new biomarkers and therapeutic targets. Gal-1, as an endogenous glycan-binding protein, has been found to influence the activity of CD8(+) regulatory T cells in CRC, suggesting a potential immunotherapeutic approach for this disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Article
Oncology
Zhenzhen Hui, Yulin Ren, Dong Zhang, Yulong Chen, Wenwen Yu, Jie Cao, Liang Liu, Tao Wang, Shanshan Xiao, Liuqing Zheng, Yue Pu, Feng Wei, Jian You, Xiubao Ren
Summary: The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) in NSCLC patients has shown significant clinical success. However, the mechanisms by which PD-1 blockade enhances the effects of chemotherapy are not fully understood. This study found that NAPC treatment resulted in increased infiltration of B cells and multiple subsets of T cells, which synergistically improved therapeutic response. Additionally, PD-1 blockade promoted anti-tumor immunity by recruiting T cells and B cells in the tumor microenvironment.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eunjung Cho, Seongeun Han, Hyeon Seok Eom, Sang-Jin Lee, Chungyong Han, Rohit Singh, Seon-Hee Kim, Bo-Mi Park, Byoung-Gie Kim, Young H. Kim, Byoung S. Kwon, Ki Taek Nam, Beom K. Choi
Summary: The interaction between regulatory T (Treg) cells and self-reactive T cells is crucial for maintaining immune tolerance. This study reveals that self-antigens can activate CD8(+) T cells and induce delayed proliferation of Treg cells. The P53 signaling pathway plays a critical role in this process. Understanding the mechanisms of Treg cell stimulation and its implications in autoimmune diseases and cancer immunotherapy is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lenian Lu, Jie Sun, Hang Su, Shi Luo, Jianmin Chen, Shengcong Qiu, Yajie Chi, Jiye Lin, Xiaobing Xu, Dahai Zheng
Summary: The study found significantly elevated levels of Tfr cells in CD4 T cells infiltrating glioma tumors, and these cells can significantly suppress the proliferation and cytotoxic capacity of CD8 T cells toward glioma cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Anneline C. Hinrichs, Sofie L. M. Blokland, Aike A. Kruize, Floris P. J. Lafeber, Helen L. Leavis, Joel A. G. van Roon
Summary: The expression of CCL5 by CCR9+ CD8 T cells in primary Sjogren's syndrome (pSS) patients was studied in this research. The results showed an increased frequency of circulating CCR9+ CD8 T cells in pSS patients compared to healthy controls (HC). Antigen-experienced CD8 T cells, especially CCR9+ effector CD8 T cells, expressed the highest levels of CCL5 and released the highest levels of CCL5 upon activation. Furthermore, CCR9+ CD8 T cells rapidly released CCL5 and significantly more than CCR9+ CD4 T cells. These findings suggest that CCL5 release by CCR9+ CD8 T cells contributes to immunopathology in pSS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuzo Koda, Toshiaki Teratani, Po-Sung Chu, Yuya Hagihara, Yohei Mikami, Yosuke Harada, Hanako Tsujikawa, Kentaro Miyamoto, Takahiro Suzuki, Nobuhito Taniki, Tomohisa Sujino, Michiie Sakamoto, Takanori Kanai, Nobuhiro Nakamoto
Summary: The study identified CD8+ tissue-resident memory T cells as key players in resolving liver fibrosis, potentially through Fas-mediated cytotoxicity to eliminate hepatic stellate cells.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen
Summary: We discovered an enrichment of PD-L1(+)CD8(+) T cells in lung cancer, which were spatially localized with PD-1(+)CD8(+) T cells. These PD-L1(+)CD8(+) T cells exhibited regulatory functions that inhibited the proliferation and cytotoxic abilities of other CD8(+) T cells through the PD-L1/PD-1 axis. Tumor-derived IL-27 was found to promote the development of PD-L1(+)CD8(+) T cells through STAT1/STAT3 signaling, leading to downregulation of the adaptive immune response.
Article
Cell Biology
Menglu Gao, Yili Liu, Mingquan Guo, Qianying Wang, Yan Wang, Jian Fan, Yinzhong Shen, Junjie Hou, Yanmin Wan, Zhaoqin Zhu
Summary: The study found that frequencies of lymphocytes and T cells decreased significantly in COVID-19 patients, while the CD4(+)/CD8(+)T cell ratios increased significantly in patients over 45 years old. Regulatory CD4(+) and CD8(+) T cells may play distinct roles in the pathogenesis of COVID-19, and NK cells might contribute to the lymphopenia associated with COVID-19.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Helenie Kefalakes, Xylia J. Horgan, Min Kyung Jung, Georgios Amanakis, Devika Kapuria, Fabian J. Bolte, David E. Kleiner, Christopher Koh, Theo Heller, Barbara Rehermann
Summary: This study found that patients infected with HDV had reduced but more activated innate immune cell populations in the liver, and an activated, memory-like, tissue-resident HDV-specific CD8(+) T-cell cluster was identified. Antigen-nonspecific activation of liver-resident CD8(+) T cells may contribute to inflammation and disease progression in HDV infection.
Article
Gastroenterology & Hepatology
Cara L. Mack, David Adams, David N. Assis, Nanda Kerkar, Michael P. Manns, Marlyn J. Mayo, John M. Vierling, Mouaz Alsawas, Mohammad H. Murad, Albert J. Czaja
Correction
Multidisciplinary Sciences
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor
NATURE COMMUNICATIONS
(2020)
Review
Gastroenterology & Hepatology
John M. Vierling, Nanda Kerkar, Albert J. Czaja, Cara L. Mack, David Adams, David N. Assis, Michael P. Manns, Marlyn J. Mayo, Tarek Nayfeh, Abdul Mounaem M. Majzoub, Muayad A. Alzuabi, Jingyi Ding, Samir Haffar, M. Hassan Murad, Mouaz Alsawas
Article
Multidisciplinary Sciences
Hynek Mergental, Richard W. Laing, Amanda J. Kirkham, M. Thamara P. R. Perera, Yuri L. Boteon, Joseph Attard, Darren Barton, Stuart Curbishley, Manpreet Wilkhu, Desley A. H. Neil, Stefan G. Hubscher, Paolo Muiesan, John R. Isaac, Keith J. Roberts, Manuel Abradelo, Andrea Schlegel, James Ferguson, Hentie Cilliers, Julian Bion, David H. Adams, Chris Morris, Peter J. Friend, Christina Yap, Simon C. Afford, Darius F. Mirza
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Sarah Faull, Emma L. K. Elliston, Bibek Gooptu, Alistair M. Jagger, Ibrahim Aldobiyan, Adam Redzej, Magd Badaoui, Nina Heyer-Chauhan, S. Tamir Rashid, Gary M. Reynolds, David H. Adams, Elena Miranda, Elena Orlova, James A. Irving, David A. Lomas
Article
Gastroenterology & Hepatology
Guru Trikudanathan, B. Joseph Elmunzer, Yi Yang, Maisam Abu-El-Haija, David Adams, Syed Ahmad, Appakalai N. Balamurugan, Gregory J. Beilman, Srinath Chinnakotla, Darwin L. Conwell, Martin L. Freeman, Timothy B. Gardner, Betul Hatipoglu, James S. Hodges, Varvara Kirchner, Luis F. Lara, Leslie Long-Simpson, Rebecca Mitchell, Katherine Morgan, Jaimie D. Nathan, Bashoo Naziruddin, Andrew Posselt, Timothy L. Pruett, Sarah J. Schwarzenberg, Vikesh K. Singh, Kerrington Smith, Martin Wijkstrom, Piotr Witkowski, Melena D. Bellin
Summary: The study found associations between pre-operative ERCP and ERCP frequency with clinical characteristics and islet yield in patients undergoing TPIAT. However, pre-operative ERCP did not significantly impact islet yield. Therefore, ERCP can be performed as needed without withholding to optimize surgical outcomes.
Article
Biotechnology & Applied Microbiology
Markus Muttenthaler, Glenn E. King, David J. Adams, Paul E. Alewood
Summary: This Perspective summarizes key trends in peptide drug discovery and development, including human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry. It also emphasizes lessons from earlier approaches that are still relevant today and discusses emerging strategies impact on peptide drug discovery.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Pharmacology & Pharmacy
Jeffrey R. McArthur, Nehan R. Munasinghe, Rocio K. Finol-Urdaneta, David J. Adams, Macdonald J. Christie
Summary: Research has shown that Pn3a produces analgesic effects by inhibiting HVA Ca(v), with enhanced inhibition observed when co-administered with opioid agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
David H. Adams
Article
Gastroenterology & Hepatology
Richard Taubert, Bastian Engel, Jana Diestelhorst, Katharina L. Hupa-Breier, Patrick Behrendt, Niklas T. Baerlecken, Kurt-Wolfram Suehs, Maciej K. Janik, Kalliopi Zachou, Marcial Sebode, Christoph Schramm, Maria-Carlota Londono, Sarah Habes, Ye H. Oo, Claudine Lalanne, Simon Pape, Maren Schubert, Michael Hust, Stefan Duebel, Mario Thevis, Danny Jonigk, Julia Beimdiek, Falk F. R. Buettner, Joost P. H. Drenth, Luigi Muratori, David H. Adams, Jessica K. Dyson, Amedee Renand, Isabel Graupera, Ansgar W. Lohse, George N. Dalekos, Piotr Milkiewicz, Martin Stangel, Benjamin Maasoumy, Torsten Witte, Heiner Wedemeyer, Michael P. Manns, Elmar Jaeckel
Summary: This study identified more accurate autoantibodies for diagnosing autoimmune hepatitis (AIH) using a protein macroarray, which showed higher specificity and sensitivity compared to conventional autoantibodies. These antibodies could be used as promising markers to improve the diagnostic workup of liver diseases, particularly in cases of seronegative AIH.
Editorial Material
Gastroenterology & Hepatology
David H. Adams
JOURNAL OF HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Bastian Engel, Richard Taubert, Jana Diestelhorst, Katharina Luise Hupa-Breier, Emily Saunders, Theresa Kirchner, Anna Baumann, Patrick Behrendt, Niklas T. Baerlecken, Kurt-Wolfram Suehs, Maciej K. Janik, Kalliopi Zachou, Marcial Sebode, Christoph Schramm, Maria Carlota Londono, Sarah Habes, Ye Htun Oo, Claudine Lalanne, Simon Pape, Maren Schubert, Michael Hust, Stefan Duebel, Mario Thevis, Danny Jonigk, Joost Ph Drenth, Luigi Muratori, David Adams, Jessica Dyson, Amedee Renand, Isabel Graupera, Ansgar W. Lohse, George Dalekos, Piotr Milkiewicz, Martin Stangel, Benjamin Maasoumy, Torsten Witte, Heiner Wedemeyer, Michael P. Manns, Elmar Jaeckel
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kathryn Olsen, James Hodson, Vincenzo Ronza, Amber G. Bozward, Ennifer Hayden, Grace Wootton, Matthew Armstrong, David H. Adams, Omar El-Sherif, James Ferguson, Ellen Knox, Tracey Johnston, Fiona Thompson, Ye Htun Oo
Summary: AIH shows improvement in biochemical and immunological parameters during pregnancy, but postpartum flare is common. Type 2 AIH is associated with a higher risk of premature birth and postpartum flare, while medication nonadherence may increase these risks. Further research is needed to confirm and explain these findings.
HEPATOLOGY COMMUNICATIONS
(2021)
Meeting Abstract
Oncology
Adi Nagler, Shelly Kalaora, Deborah Gitta Rosenberg, Michal Alon, Eilon Barnea, Ronen Levy, Kevin Vervier, Sophie Trabish, Tali Dadosh, Smadar Zaidman, Leore Geller, Polina Greenberg, Neerupma Bhardwaj, Alexandre Reuben, Reetakshi Arora, Michal Lotem, Arie Admon, Yishai Levin, Trevor Lawley, David Adams, Naama Geva-Zatorsky, Jennifer Wargo, Ravid Straussman, Yardena Samuels
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)