Review
Immunology
Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Summary: TCR signaling plays a crucial role in the development of T cells and the formation of self-reactive T cells, particularly in type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Multidisciplinary Sciences
Todd M. Brusko, Holger A. Russ, Cherie L. Stabler
Summary: Advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for individuals with type 1 diabetes, but still fall short of the metabolic control provided by native islets. Integrated advancements in islet cell replacement and immunomodulatory therapies are offering hope for the restoration of endogenous glucose regulation. Progress in stem cell biology and graft site design are providing innovative sources for cellular material and improved engraftment.
Review
Endocrinology & Metabolism
Kriti Joshi, Fergus Cameron, Swasti Tiwari, Stuart I. Mannering, Andrew G. Elefanty, Edouard G. Stanley
Summary: Induced pluripotent stem cell (iPSC) technology is increasingly used to create in vitro models of monogenic human disorders, while complex conditions like autoimmune Type 1 diabetes (T1D) may require consideration of polygenic inheritance and environmental factors. Models for T1D should be aware of the importance of cell interactions and genetic backgrounds for more accurate representation of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Heejoo Kim, Jelena Perovanovic, Arvind Shakya, Zuolian Shen, Cody N. German, Andrea Ibarra, Jillian L. Jafek, Nai-Pin Lin, Brian D. Evavold, Danny H-C Chou, Peter E. Jensen, Xiao He, Dean Tantin
Summary: Loss of T cell-specific OCA-B protects mice from spontaneous autoimmune diabetes by reducing CD8(+) T cell receptor specificities associated with diabetes pathogenesis. The protective effect is recapitulated using autoantigen-specific NY8.3 mice but diminished in monoclonal models specific to artificial or neoantigens. Rational design of membrane-penetrating OCA-B peptide inhibitors normalizes glucose levels and reduces T cell infiltration and proinflammatory cytokine expression in newly diabetic NOD mice.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Maki Nakayama, Aaron W. Michels
Summary: TCRs serve as unique markers that define antigen specificity for T cells, making them prime candidates for next-generation T cell biomarkers. Developing TCR biomarkers for T1D could potentially provide powerful tools for assessing disease activity and treatment development in diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Farooq Riaz, Ping Wei, Fan Pan
Summary: This review highlights the multifaceted roles of Peroxisome Proliferator-Activated Receptors (PPARs) in T-cell-mediated autoimmune type 1 diabetes (T1D), shedding light on their potential as regulators of immune responses and beta-cell biology. Recent research has elucidated the intricate interplay between CD4+ T cell subsets, such as Tregs and Th17, in developing autoimmune diseases like T1D. PPARs, initially recognized for their role in lipid metabolism, have emerged as potent modulators of inflammation in T1D.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Review
Endocrinology & Metabolism
Eddie A. James, Alok V. Joglekar, Amelia K. Linnemann, Holger A. Russ, Sally C. Kent
Summary: In this article, the authors discuss the interface between islet beta cells and immune infiltrates, with a focus on T cells, in the context of T1D. They emphasize the importance of studying pancreatic and immune cell phenotypes and their impact on cell function to gain a comprehensive understanding of T1D disease etiology in humans. They also highlight the active role of beta cells and the critical axis of the T cell-beta cell interface in autoimmune responses.
MOLECULAR METABOLISM
(2023)
Article
Cell & Tissue Engineering
Mahmoud Izadi, Anavasadat Sadr Hashemi Nejad, Maedeh Moazenchi, Safdar Masoumi, Ali Rabbani, Farzad Kompani, Amir Abbas Hedayati Asl, Fatemeh Abbasi Kakroodi, Neda Jaroughi, Mohammad Ali Mohseni Meybodi, Aria Setoodeh, Farzaneh Abbasi, Seyedeh Esmat Hosseini, Fatemeh Moeini Nia, Reza Salman Yazdi, Roghayeh Navabi, Ensiyeh Hajizadeh-Saffar, Hossein Baharvand
Summary: This study evaluated the safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) transplantation via intravenous injection in newly diagnosed type-1 diabetes (T1D) patients. The results showed that MSCs transplantation is safe, reduces hypoglycemic episodes, improves glycemic control and immune function, and enhances quality of life in T1D patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Maki Nakayama, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, Aaron W. Michels
Summary: In type 1 diabetes, T-cell responses to hybrid insulin peptides (HIPs) may precede clinical symptoms and be associated with disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Leeana D. Peters, Wen- Yeh, Juan M. Arnoletti, Matthew E. Brown, Amanda L. Posgai, Clayton E. Mathews, Todd M. Brusko
Summary: The autoimmune pathogenesis of T1D involves immune cell infiltration into pancreatic islets. CD8(+) T cells play a primary role in killing insulin-producing beta-cells. This study demonstrates the engineering of human T cells to improve the specificity and function of autoreactive CD8(+) T cells, potentially leading to cellular therapeutics for treating autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zehra Karakoese, Mara Schwerdtfeger, Christina B. Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter
Summary: Specific type I IFN subtypes (IFNα2, IFNα14, and IFNβ) exert distinct potencies in stimulating T and NK cell responses during HIV-1 infection. IFNα14 and IFNβ significantly increase the frequencies of degranulating gut-derived CD4(+) T cells and blood-derived T and NK cells, while reducing the frequencies of IFNγ-expressing T cells. Moreover, subtype-specific phosphorylation of downstream molecules and differences in STAT5 phosphorylation were observed in healthy peripheral blood mononuclear cells (PBMCs) and PBMCs of HIV-infected individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Friederike
Summary: CAR T cell therapy has shown potential in treating hematologic cancers but is limited in solid tumors. Chronic stimulation of CAR T cells propagates inhibitory type I interferon signaling, hindering antitumor function. Knocking out the EGR2 transcriptional regulator improves CAR T cell efficacy and blocks interferon-induced dysfunction. The gene signature of EGR2 is a biomarker for CAR T cell failure and patient survival. Modulating CAR T cell-intrinsic resistance is crucial for improving therapy outcomes.
Review
Endocrinology & Metabolism
Mengdi Zhang, Yanyan Zhou, Zhiguo Xie, Shuoming Luo, Zhiguang Zhou, Jiaqi Huang, Bin Zhao
Summary: This review discusses the metabolic reprogramming of T cells in the development of T1D, as well as the key metabolic pathways and regulators that modulate T cell homeostasis, differentiation, and function. Metabolic intervention can be used to suppress autoreactive T cells and limit the progression of beta-cell destruction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Multidisciplinary Sciences
Jeffrey A. Bluestone, Jane H. Buckner, Kevan C. Herold
Summary: Type 1 diabetes (T1D) is an autoimmune disease where T cells attack and destroy insulin-producing beta cells in the pancreas. While insulin therapy helps with symptoms, it does not cure the underlying disease or fully prevent complications. Current research is focused on developing immunological therapies to prevent and modify T1D.
Article
Immunology
Alexander P. R. Bally, Yan Tang, Joshua T. Lee, Benjamin G. Barwick, Ryan Martinez, Brian D. Evavold, Jeremy M. Boss
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Lori Blanchfield, Joseph J. Sabatino, Laurel Lawrence, Brian D. Evavold
JOURNAL OF IMMUNOLOGY
(2017)
Editorial Material
Immunology
Brian M. Baker, Brian D. Evavold
TRENDS IN IMMUNOLOGY
(2017)
Article
Immunology
David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre J. Rizkallah, Andrew K. Sewell
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Rakieb Andargachew, Ryan J. Martinez, Elizabeth M. Kolawole, Brian D. Evavold
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Anna Sanecka, Nagisa Yoshida, Elizabeth Motunrayo Kolawole, Harshil Patel, Brian D. Evavold, Eva-Maria Frickel
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Endocrinology & Metabolism
Baoyu Liu, Jennifer D. Hood, Elizabeth M. Kolawole, Derek M. Woodruff, Dario A. Vignali, Maria Bettini, Brian D. Evavold
Article
Endocrinology & Metabolism
Maria Bettini, Marissa A. Scavuzzo, Baoyu Liu, Elizabeth Kolawole, Lin Guo, Brian D. Evavold, Malgorzata Borowiak, Matthew L. Bettini
Article
Immunology
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S. M. Rahman, Brian D. Evavold, Aron E. Lukacher
SCIENCE IMMUNOLOGY
(2020)
Article
Immunology
Heejoo Kim, Jelena Perovanovic, Arvind Shakya, Zuolian Shen, Cody N. German, Andrea Ibarra, Jillian L. Jafek, Nai-Pin Lin, Brian D. Evavold, Danny H-C Chou, Peter E. Jensen, Xiao He, Dean Tantin
Summary: Loss of T cell-specific OCA-B protects mice from spontaneous autoimmune diabetes by reducing CD8(+) T cell receptor specificities associated with diabetes pathogenesis. The protective effect is recapitulated using autoantigen-specific NY8.3 mice but diminished in monoclonal models specific to artificial or neoantigens. Rational design of membrane-penetrating OCA-B peptide inhibitors normalizes glucose levels and reduces T cell infiltration and proinflammatory cytokine expression in newly diabetic NOD mice.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Victor Pui-Yan Ma, Yuesong Hu, Anna Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, Khalid Salaita
Summary: T cells defend against cancer and viral infections by binding to specific peptide antigens on target cells. It has been found that the forces transmitted through the LFA-1 /ICAM-1 complex can tune T cell signaling and enhance T cell activation and TCR discrimination.
Article
Immunology
Nguyen X. Nguyen, Andrew W. Richens, Linda M. Sircy, Denise E. Allard, Elizabeth M. Kolawole, Brian D. Evavold, Maria Bettini, J. Scott Hale
Summary: The AIM assay is a cytokine-independent technique for identifying Ag-specific T cells based on upregulated expression of activation markers after Ag restimulation. This study analyzed immune responses of TCR-transgenic CD4+ T cells and found that the AIM assay is effective for identifying the frequency of protein immunization-induced effector and memory CD4+ T cells but has limitations in identifying cells induced by viral infection, especially chronic infection. The findings suggest that the AIM assay is a useful tool for quantifying murine Ag-specific CD4+ T cells in protein vaccination.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Aaron M. Rosado, Yan Zhang, Hyun-Kyu Choi, Yunfeng Chen, Samuel M. Ehrlich, Fengzhi Jin, Arash Grakoui, Brian D. Evavold, Cheng Zhu
Summary: Protein-protein interactions play a crucial role in coordinating biological processes and can affect an organism's responses to changing environments and diseases. In this study, we discuss memory effects in repetitive protein-protein interactions and propose several mathematical models for quantitatively analyzing these effects. We found that interactions between cell membrane proteins and peptide-major histocompatibility complex exhibit short-term memory, while peptide dissociation from MHC results in intermediate- and long-term memories. This research provides valuable insights into the mechanisms of protein interactions and can aid future studies.
APL BIOENGINEERING
(2023)
Correction
Oncology
Tamson Moore, Courtney Regan Wagner, Gina M. Scurti, Kelli A. Hutchens, Constantine Godellas, Ann Lau Clark, Elizabeth Motunrayo Kolawole, Lance M. Hellman, Nishant K. Singh, Fernando A. Huyke, Siao-Yi Wang, Kelly M. Calabrese, Heather D. Embree, Rimas Orentas, Keisuke Shirai, Emilia Dellacecca, Elizabeth Garrett-Mayer, Mingli Li, Jonathan M. Eby, Patrick J. Stiff, Brian D. Evavold, Brian M. Baker, I. Caroline Le Poole, Boro Dropulic, Joseph I. Clark, Michael I. Nishimura
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Oncology
Tamson Moore, Courtney Regan Wagner, Gina M. Scurti, Kelli A. Hutchens, Constantine Godellas, Ann Lau Clark, Elizabeth Motunrayo Kolawole, Lance M. Hellman, Nishant K. Singh, Fernando A. Huyke, Siao-Yi Wang, Kelly M. Calabrese, Heather D. Embree, Rimas Orentas, Keisuke Shirai, Emilia Dellacecca, Elizabeth Garrett-Mayer, Mingli Li, Jonathan M. Eby, Patrick J. Stiff, Brian D. Evavold, Brian M. Baker, I. Caroline Le Poole, Boro Dropulic, Joseph I. Clark, Michael I. Nishimura
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)