T-type Ca2+ channels in absence epilepsy

Sleep spindles are generated in the absence of T-type calcium channel-mediated low-threshold burst firing of thalamocortical neurons

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Type Calcium Channels Consolidate Tonic Action Potential Output of Thalamic Neurons to Neocortex

(2012) C. Deleuze et al.   JOURNAL OF NEUROSCIENCE

Closed-Loop Control of Epilepsy by Transcranial Electrical Stimulation

(2012) A. Berenyi et al.   SCIENCE

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

(2012) E. Tringham et al.   Science Translational Medicine

Thalamic T-Type Ca2+ Channels Mediate Frontal Lobe Dysfunctions Caused by a Hypoxia-Like Damage in the Prefrontal Cortex

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy

(2011) Jeanne T Paz et al.   NATURE NEUROSCIENCE

From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?

(2011) Nathalie Leresche et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The CaV3.3 calcium channel is the major sleep spindle pacemaker in thalamus

(2011) S. Astori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes as Gatekeepers of GABAB Receptor Function

(2010) M. P. Beenhakker et al.   JOURNAL OF NEUROSCIENCE

Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow

(2010) F. M. Dreyfus et al.   JOURNAL OF NEUROSCIENCE

In Vitro Characterization of T-Type Calcium Channel Antagonist TTA-A2 and In Vivo Effects on Arousal in Mice

(2010) R. L. Kraus et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy

(2010) Tracy A. Glauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists

(2009) Victor N. Uebele et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Thalamic lesions in a genetic rat model of absence epilepsy: Dissociation between spike-wave discharges and sleep spindles

(2009) Hanneke K.M. Meeren et al.   EXPERIMENTAL NEUROLOGY

A Cav3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

(2009) K. L. Powell et al.   JOURNAL OF NEUROSCIENCE

Genetic Enhancement of Thalamocortical Network Activity by Elevating  1G-Mediated Low-Voltage-Activated Calcium Current Induces Pure Absence Epilepsy

(2009) W. L. Ernst et al.   JOURNAL OF NEUROSCIENCE

G Protein-Mediated Inhibition of Cav3.2 T-Type Channels Revisited

(2009) E. Perez-Reyes   MOLECULAR PHARMACOLOGY

Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy?

(2009) Mark P. Beenhakker et al.   NEURON

Deletion of phospholipase C  4 in thalamocortical relay nucleus leads to absence seizures

(2009) E. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures

(2009) C. M. Schofield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-type Ca2+ channels as therapeutic targets in the nervous system

(2008) H SHIN et al.   CURRENT OPINION IN PHARMACOLOGY

Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+Channel Antagonist

(2008) William D. Shipe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning Thalamic Firing Modes via Simultaneous Modulation of T- and L-Type Ca2+ Channels Controls Pain Sensory Gating in the Thalamus

(2008) E. Cheong et al.   JOURNAL OF NEUROSCIENCE

Correlation of T-channel coding gene expression, IT, and the low threshold Ca2+ spike in the thalamus of a rat model of absence epilepsy

(2008) Tilman Broicher et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites

(2008) Lucius Cueni et al.   NATURE NEUROSCIENCE