Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

A polyphasic approach leading to the revision of the genus Planktothrix (Cyanobacteria) and its type species, P. agardhii, and proposal for integrating the emended valid botanical taxa, as well as three new species, Planktothrix paucivesiculata sp. nov.ICNP, Planktothrix tepida sp. nov.ICNP, and Planktothrix serta sp. nov.ICNP, as genus and species names with nomenclatural standing under the ICNP

(2015) Virginie Gaget et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Acyl-Chain Elongation Drives Ketosynthase Substrate Selectivity intrans-Acyltransferase Polyketide Synthases

(2014) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dehydratase Domain in Ambruticin Biosynthesis Displays Additional Activity as a Pyran-Forming Cyclase

(2014) Gesche Berkhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

(2014) Toshiyuki Wakimoto et al.   Nature Chemical Biology

An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

(2013) Petra Pöplau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Defensive Bacteriome Symbiont with a Drastically Reduced Genome

(2013) Atsushi Nakabachi et al.   CURRENT BIOLOGY

Computational identification and analysis of orphan assembly-line polyketide synthases

(2013) Robert V O'Brien et al.   JOURNAL OF ANTIBIOTICS

Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills

(2013) Sherif I. Elshahawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses

(2013) A. Kampa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate

(2013) Christoph Kohlhaas et al.   Chemical Science

Substrate Specificity in Ketosynthase Domains fromtrans-AT Polyketide Synthases

(2012) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of the Rhizopodin Biosynthetic Gene Cluster in Stigmatella aurantiaca Sg a15 by Genome Mining

(2012) Dominik Pistorius et al.   CHEMBIOCHEM

Primer on Agar-Based Microbial Imaging Mass Spectrometry

(2012) J. Y. Yang et al.   JOURNAL OF BACTERIOLOGY

Mass spectral molecular networking of living microbial colonies

(2012) J. Watrous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis

(2011) M. S. Donia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mathFISH, a Web Tool That Uses Thermodynamics-Based Mathematical Models forIn SilicoEvaluation of Oligonucleotide Probes for FluorescenceIn SituHybridization

(2010) L. Safak Yilmaz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes

(2010) Roberta Teta  et al.   CHEMBIOCHEM

Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS

(2010) Herbert Irschik  et al.   CHEMBIOCHEM

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

(2009) Katja M Fisch et al.   Nature Chemical Biology

Shifting the genomic gold standard for the prokaryotic species definition

(2009) Michael Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luminaolide, a novel metamorphosis-enhancing macrodiolide for scleractinian coral larvae from crustose coralline algae

(2009) Makoto Kitamura et al.   TETRAHEDRON LETTERS

Synthetic Mimetics of Actin-Binding Macrolides: Rational Design of Actin-Targeted Drugs

(2008) Richard D. Perrins et al.   CHEMISTRY & BIOLOGY

Something from (almost) nothing: the impact of multiple displacement amplification on microbial ecology

(2008) Erik K Binga et al.   ISME Journal

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY