Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin

Nonclassical CH−π Supramolecular Interactions in Artemisinic Acid Favor a Single Conformation, Yielding High Diastereoselectivity in the Reduction with Diazene

(2014) Bertrand Castro et al.   JOURNAL OF ORGANIC CHEMISTRY

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Semisynthetic Artemisinin, the Chemical Path to Industrial Production

(2014) Joël Turconi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Artemisinin: A Case Study in the Evolution of Synthetic Strategy

(2014) Silas Cook   SYNLETT

A Continuous-Flow Process for the Synthesis of Artemisinin

(2013) Daniel Kopetzki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

(2013) D. Tyler McQuade et al.   JOURNAL OF ORGANIC CHEMISTRY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Pilot Plant PAT Approach for the Diastereoselective Diimide Reduction of Artemisinic Acid

(2013) Martin P. Feth et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin

(2013) Jianqiang Kong et al.   RSC Advances

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Concise Synthesis of (+)-Artemisinin

(2012) Chunyin Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photochemical technologies assessed: the case of rose oxide

(2011) Davide Ravelli et al.   GREEN CHEMISTRY

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Generation of the potent anti-malarial drug artemisinin in tobacco

(2011) Moran Farhi et al.   NATURE BIOTECHNOLOGY

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

The Threat of Artemisinin-Resistant Malaria

(2011) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly Efficient Continuous Flow Reactions Using Singlet Oxygen as a “Green” Reagent

(2011) François Lévesque et al.   ORGANIC LETTERS

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

(2010) Geoffrey D. Brown   MOLECULES

A concise stereoselective total synthesis of (+)-artemisinin

(2010) J.S. Yadav et al.   TETRAHEDRON

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

“Dark” Singlet Oxygenation of β-Citronellol: A Key Step in the Manufacture of Rose Oxide

(2009) Paul L. Alsters et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE