Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies1,2

FGF21 drives a shift in adipokine tone to restore metabolic health

(2016) Andrew Charles Adams et al.   Aging-US

Differential Enzyme-Linked Immunosorbent Assay and Ligand-Binding Mass Spectrometry for Analysis of Biotransformation of Protein Therapeutics: Application to Various FGF21 Modalities

(2013) Todd Hager et al.   ANALYTICAL CHEMISTRY

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

(2013) Raul C. Camacho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

(2013) Alexei Kharitonenkov et al.   PLoS One

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

(2013) Andrew C. Adams et al.   Molecular Metabolism

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

(2012) Johan W. Jonker et al.   NATURE

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

(2012) Andrew C. Adams et al.   PLoS One

FGF21 Requires βklotho to Act In Vivo

(2012) Andrew C. Adams et al.   PLoS One

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

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(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol

(2011) Zhifeng Huang et al.   PLoS One

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

(2010) Nobuyuki Itoh   CELL AND TISSUE RESEARCH

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 reloaded: challenges of a rapidly growing field

(2010) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FGFs and metabolism

(2009) Alexei Kharitonenkov   CURRENT OPINION IN PHARMACOLOGY

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

(2009) Charis L. Johnson et al.   GASTROENTEROLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

The Klotho gene family and the endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 N- and C-termini play different roles in receptor interaction and activation

(2008) Junming Yie et al.   FEBS LETTERS

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY