Article
Multidisciplinary Sciences
Evangelia Argyriou, Giorgos Bakoyannis, Wei Wu, Mary Jo Rattermann, Melissa A. A. Cyders
Summary: This study examined treatment course patterns in a community SUD clinic and found that primary opioid use disorder diagnosis was associated with higher risk of premature treatment termination. Additionally, depressive symptoms level during treatment, primary SUD diagnosis, and lifetime misuse of multiple substances were found to be risk factors for treatment readmission.
Review
Biochemistry & Molecular Biology
Airton C. Martins, Caridad Lopez-Granero, Beatriz Ferrer, Alexey A. Tinkov, Anatoly V. Skalny, Monica M. B. Paoliello, Michael Aschner
Summary: BXD recombinant inbred (RI) lines serve as a genetic reference population, aiding in the study of genetic diversity and disease susceptibility. QTL mapping is a typical approach to identify naturally occurring polymorphisms that influence complex phenotypes.
Review
Biochemistry & Molecular Biology
Michael T. McCoy, Subramaniam Jayanthi, Jean Lud Cadet
Summary: The potential of using potassium channel activators in SUD treatment has been discussed, as they have been shown to reduce alcohol intake and augment the behavioral effects of opioid drugs. Studies focusing on the role of potassium channels as targets for therapeutic interventions against SUDs are warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Toxicology
Cheng Guo, Lei Chen, Yun Wang
Summary: Psychostimulants and alcohol abuse have negative effects on global public health, especially in relation to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The pathogenesis of neurodegenerative diseases involves oxidative stress, mitochondrial dysfunction, metal homeostasis disorder, and neuro-inflammation. Understanding the molecular mechanisms of neurodegeneration and identifying therapeutic targets is crucial for treatment and prevention.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Clinical Neurology
Chenyuan Qin, Jiawei Hu, Yiming Wan, Mengyao Cai, Zhenting Wang, Zhao Peng, Yuxiao Liao, Dan Li, Ping Yao, Liegang Liu, Shuang Rong, Wei Bao, Guifeng Xu, Wei Yang
Summary: This review primarily focuses on the relationships between alcohol, cocaine, and methamphetamine addiction and gut microbiota, as well as possible treatment methods. By establishing a bridge between substance addiction and gut microbiota based on existing evidence, the review aims to explore the potential bidirectional function of the microbiota-gut-brain axis in substance addiction for the development of therapeutic strategies in the future.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Chemistry, Medicinal
Nazzareno Cannella, Anna Maria Borruto, Michele Petrella, Maria Vittoria Micioni Di Bonaventura, Laura Soverchia, Carlo Cifani, Sara De Carlo, Esi Domi, Massimo Ubaldi
Summary: The neuropeptide S (NPS) and its receptor (NPSR) play an important role in the processing of emotional and affective behavior. NPS has both anxiolytic and arousal-promoting effects. It reduces alcohol consumption in alcohol-preferring rats and increases the anxiolytic effects in rodents with a history of alcohol dependence. These findings suggest that the NPS/NPSR system could be a potential target for treating alcohol and cocaine abuse.
Review
Behavioral Sciences
Alessandra Matzeu, Remi Martin-Fardon
Summary: Orexins are neuropeptides that regulate energy metabolism, sleep, feeding, and stress responses, making them an ideal target for studying addiction and discovering treatments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ernest T. Chivero, Raghubendra Singh Dagur, Eric S. Peeples, Susmita Sil, Ke Liao, Rong Ma, Liang Chen, Channabasavaiah B. Gurumurthy, Shilpa Buch, Guoku Hu
Summary: Substance use disorder (SUD) is a growing health problem affecting millions worldwide, with extracellular vesicles (EVs) playing a crucial role in its pathogenesis. EVs have the potential to serve as biomarkers or therapeutic targets in SUD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Psychiatry
Chintan Trivedi, Rupak Desai, John Rafael, Stephanie Bui, Karrar Husain, Abid Rizvi, Mudasar Hassan, Zeeshan Mansuri, Shailesh Jain
Summary: This study investigated and compared the prevalence of mental health disorders (MHD) and substance use disorders (SUD) in hospitalized patients between 2007 and 2017. The results showed a significant increase in the prevalence of substance use disorders and psychiatric disorders within a decade among hospitalized patients aged 18-44 years. The most notable increases were observed in amphetamine use disorders and anxiety disorders. Suicide and intentional self-inflicted injury increased across all races.
PSYCHIATRY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Stephen D. Dickson, Isac C. Thomas, Harpreet S. Bhatia, Marin Nishimura, Ehtisham Mahmud, Xin M. Tu, Tuo Lin, Eric Adler, Barry Greenberg, Laith Alshawabkeh
Summary: This study analyzed nationwide HF hospitalizations in the United States from 2002 to 2014, focusing on cases associated with methamphetamine abuse. The results showed a significant increase in MethHF hospitalizations during this period, particularly on the West Coast. Patients with MethHF were found to be younger, more likely to use Medicaid, and more likely to seek care at urban hospitals compared to non-methamphetamine associated HF patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Barbara Luque, Victoriana Garcia, Carmen Tabernero
Summary: The abuse of psychoactive substances can lead to cognitive, emotional, and behavioral disorders. This study found that different psychoactive substances have varying effects on cognitive performance and depression. Cocaine users showed the most severe cognitive impairment, while cannabis users had the best cognitive functioning. Participants with severe depression had higher cognitive impairment than those with moderate depression.
Review
Pharmacology & Pharmacy
Francisco Navarrete, Maria Salud Garcia-Gutierrez, Ani Gasparyan, Amaya Austrich-Olivares, Jorge Manzanares
Summary: CBD has been shown to have a wide range of pharmacological effects that may be beneficial for treating neuropsychiatric diseases and substance use disorders. It improves cognition, promotes neurogenesis, and has anxiolytic, antidepressant, antipsychotic, and neuroprotective effects. Numerous studies suggest that CBD regulates the reinforcing and motivational properties of various drugs of abuse.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Psychology, Clinical
Mariangela Antonelli, Liana Fattore, Luisa Sestito, Daniela Di Giuda, Marco Diana, Giovanni Addolorato
Summary: Repetitive TMS has shown promising results in patients with alcohol, tobacco, and cocaine use disorder, indicating a potential role in the treatment of SUD.
ADDICTIVE BEHAVIORS
(2021)
Article
Engineering, Chemical
Soo Youp Park, Pil -Sang Youn, Dong Hun Lee, Daewook Kim, Yooseob Won, Jeong-Hoo Choi, Ji Bong Joo, Sung-Ho Jo, Ho-Jung Ryu
Summary: This study investigates particle attrition induced by bubbles in a bubbling fluidized bed using CO2 adsorbent particles. The relationship between the rate of attrition by gas jets and the rate of attrition by bubbles is revealed, showing that the rate constant of attrition by bubbles is the product of the rate constant of attrition by gas jets and dimensionless particle diameter. The results show that the rate of attrition by bubbles is proportional to the energy given to the bed solids by bubbles, and the size of the fine particles formed by attrition increases with bed mass and gas velocity.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guoli Xiong, Zhenxing Wu, Jiacai Yi, Li Fu, Zhijiang Yang, Changyu Hsieh, Mingzhu Yin, Xiangxiang Zeng, Chengkun Wu, Aiping Lu, Xiang Chen, Tingjun Hou, Dongsheng Cao
Summary: ADMETlab 2.0 has been released with double the number of supported endpoints, including 17 physicochemical properties, 13 medicinal chemistry properties, 23 ADME properties, 27 toxicity endpoints, and 8 toxicophore rules. A multi-task graph attention framework was used to develop accurate models, with a batch computation module and optimized result representations.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
